Neonatal Sepsis due to Nontypable Haemophilus influenzae

Campognone, Paul; Singer, Don B.

doi:10.1001/archpedi.1986.02140160035025

Cited by 32 publications

(30 citation statements)

References 15 publications

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“…Neonatal invasive disease due to NTHi has been well described (4,24,50). Such cases are often diagnosed within the first 1 to 2 days of life, and prematurity is a recognized risk factor.…”

Section: Discussionmentioning

confidence: 99%

Invasive Disease Due to Nontypeable Haemophilus influenzae among Children in Arkansas

O'Neill¹,

Geme

Cutter

et al. 2003

J Clin Microbiol

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In this study, we reviewed cases of invasive disease due to nontypeable Haemophilus influenzae among children hospitalized at Arkansas Children's Hospital from 1993 to 2001. A total of 28 cases were examined, including 21 associated with bacteremia and 4 associated with meningitis. Of the patients examined, 86% were <4 years of age, and 68% had underlying medical conditions. Characterization of the bacterial isolates by multilocus sequence type genotyping revealed significant overall genetic diversity, similar to the diversity in the general population structure for nontypeable H. influenzae. However, four separate pairs of isolates were closely related genetically, a relationship confirmed by pulsed-field gel electrophoresis and Southern hybridization studies using probes for the major H. influenzae adhesin genes. These results suggest that selected strains of nontypeable H. influenzae may have more invasive potential, especially in young children and patients with underlying medical conditions. At this point, the specific factors that contribute to enhanced virulence remain unclear.

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“…Neonatal invasive disease due to NTHi has been well described (4,24,50). Such cases are often diagnosed within the first 1 to 2 days of life, and prematurity is a recognized risk factor.…”

Section: Discussionmentioning

confidence: 99%

Invasive Disease Due to Nontypeable Haemophilus influenzae among Children in Arkansas

O'Neill¹,

Geme

Cutter

et al. 2003

J Clin Microbiol

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“…The anatomic origins of the isolates are listed in Table 1. Some of the isolates have been described previously (Wallace et al, 1983;Kleiman et al, 1983;Campognone & Singer, 1986;Musser et al, 1986a;Quentin et al, 1987Quentin et al, , 1989.…”

Section: Methodsmentioning

confidence: 99%

“…Currently, 5-8% of cases of invasive neonatal diseases in some states of the USA are caused by non-encapsulated H . injluenzae (Wallace et al, 1983;Campognone & Singer, 1986), and these infections are associated with significant morbidity and mortality.…”

Section: Introductionmentioning

confidence: 99%

Urogenital, maternal and neonatal isolates of Haemophilus influenzae: identification of unusually virulent serologically non-typable clone families and evidence for a new Haemophilus species

Quentin

Goudeau

Wallace

et al. 1990

Journal of General Microbiology

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A collection of 117 strains of Haemophilus influenzae, including 112 non-typable isolates recovered predominantly in the USA and France from genital, obstetric and neonatal sources, was characterized by the electrophoretic mobilities of 10 metabolic enzymes. Eighty-six distinctive multilocus chromosomal genotypes (electrophoretic types, ETs) were distinguished on the basis of allele profiles at the enzyme loci. Isolates of five allied biotype IV ETs were highly divergent from all other strains and hybridization of chromosomal DNA revealed that they undoubtedly represent a previously unrecognized species of Haemophilus. Isolates representing these ETs were recovered predominantly from obstetric infections and serious neonatal diseases and apparently possess specific tropism for the genital tract. Strains of these five ETs were present in samples from both the USA and France, but only in the USA did they cause bacteraemia and meningitis, an occurrence which probably reflects differences in patient management between the two countries. Although strains assigned to H. influenzae (sensu stricto) were strongly polymorphic in multilocus enzyme genotype, 69 % of isolates recovered from patients with meningitis and/or septicaemia were assigned to only two clone families, a result suggesting that some serologically nontypable strains of H. influenzae originating from the genital tract are unusually virulent.

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“…Over the past few decades, the recognition of Haemophilus urogenital and neonatal infections has risen significantly (7,14,33,52). Haemophilus strains that belong to biotype IV account for up to 38% of maternal genital tract and neonatal Haemophilus infections but are rarely isolated from invasive or respiratory infections in older children or adults, suggesting a genital and neonatal tropism (1,14,26,38,52).…”

mentioning

confidence: 99%

Identification of a Novel Trimeric Autotransporter Adhesin in the Cryptic Genospecies of Haemophilus

Sheets¹,

Grass²,

Miller

et al. 2008

J Bacteriol

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Neonatal Sepsis due to Nontypable Haemophilus influenzae

Cited by 32 publications

References 15 publications

Invasive Disease Due to Nontypeable Haemophilus influenzae among Children in Arkansas

Invasive Disease Due to Nontypeable Haemophilus influenzae among Children in Arkansas

Urogenital, maternal and neonatal isolates of Haemophilus influenzae: identification of unusually virulent serologically non-typable clone families and evidence for a new Haemophilus species

Identification of a Novel Trimeric Autotransporter Adhesin in the Cryptic Genospecies of Haemophilus

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