Neonatal Septicaemia in a Rural Nigerian Hospital: Aetiology, Presentation and Antibiotic Sensitivity Pattern

Olatunde, Ogundare Ezra; Akinsoji, Akintayo Akinyemi; Florence, Dedeke; Okeniyi, John A.O.; Ademola, Adeyemi; Adetutu, Ogunlesi; Akibu, Oyelami

doi:10.9734/bjmmr/2016/22325

Cited by 10 publications

(8 citation statements)

References 7 publications

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“…[61]2017Cross-sectional251100Culture positive46.6Ethiopia67.9 (59.63,76.17)Peterside O et al [23]2015Retrospective cohort233100Culture positive43.5Nigeria21.8 (15.76,27.84)Sundarm V et al. [15]2009Retrospective cohort34362100Culture positive4.3India72.2 (63.8,80.6)Agrawal A et al. [24]2018Cross-sectional850100Culture positive5.06India26.7 (20.26,33.14)Perera KSY et al.…”

Section: Resultsmentioning

confidence: 99%

“…All studies related to neonates either admitted in the hospital or community-based studies within the neonatal period of life in African, Asian and Latin America was included in the study. These developing countries were Nigeria [7, 14, 15, 61], Nepal [16, 17, 18], Tanzania [19], Ethiopia [9, 10, 12, 20, 21], Egypt [22, 23], Bangladesh [24], Sudan [25, 26], Indonesia [27], Zambia [28], India [29, 30, 31, 32, 33] Sri Lanka [34], Uganda [35], Haiti [36], Kenya [37], Ghana [38], South Africa [8], Cameroon [39], Brazil [40], Mexico [41], Jamaica [42] and Nepal [17, 18]. Publication year: All articles published from 2005 to 2018 are used for systematic review and meta-analysis.Design: All observational studies which assessed the neonatal sepsis in developing countries are included in the study.Publication status: All published literature were included in the study.Language: Only articles published literature reported in the English language were included.…”

Section: Methodsmentioning

confidence: 99%

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Unfinished agenda of the neonates in developing countries: magnitude of neonatal sepsis: systematic review and meta-analysis

Amare

Mela

Dessie

2019

Heliyon

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PurposeNeonatal sepsis is the major cause of mortality and morbidity globally, particularly in developing countries. Despite studies revealed the extent of neonatal sepsis in developing countries, the findings were inconclusive. Therefore, the main aim of this study was to determine the pooled prevalence of neonatal sepsis in developing countries.MethodsWe used a systematic review and Meta-analysis study method. The reviewed studies were accessed through an electronic web-based search strategy from the electronic database (PUBMED), advanced google scholar, different journal sites. The data extraction was done by two researchers using a data extraction table and the disparity between data extractors was resolved by the third researcher. The analysis was done using STATA version 11. The I2 test was used to assess heterogeneity across studies. The Funnel plot, Begg's test, and Egger's test were used to check for publication bias. The random-effect model was used to determine the pooled effect size. All studies related to neonatal sepsis which fulfill the inclusion criteria were considered into this study. The quality of each study was checked using the Newcastle-Ottawa Scale and studies graded low score were excluded from the study.ResultsAt the end, 36 articles fit with our study objectives. Studies conducted in Ethiopia were significant the source of heterogeneity of the study with a coefficient = 90, P-value = 0.025. The overall pooled prevalence of the study was 29.92%. The limitations of this study would be the authors were only used articles reported in the English language, and publication bias.ConclusionThe pooled prevalence of neonatal sepsis was found to be high which accounted for a third of the neonates. Despite countries have established possible prevention and treatment mechanisms, neonatal sepsis is the major public health problem in lower and middle-income countries till now.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Unfinished agenda of the neonates in developing countries: magnitude of neonatal sepsis: systematic review and meta-analysis

Amare

Mela

Dessie

2019

Heliyon

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“…One of these studies used new-born weight to determine the volume of blood to collect for culture[ 25 ]. Overall blood culture yield across all studies was 24.5% but ranged from 20% [ 27 ] to 56% [ 48 ]. Eleven studies were retrospective while another 12 were prospective.…”

Section: Resultsmentioning

confidence: 99%

“…Two studies were done in multiple hospitals: one in three and the other in four hospitals[ 25 , 49 ]. Two studies were carried out at different times in the same rural area while all others were in urban areas[ 27 , 47 ]. None took place in a primary health care center.…”

Section: Resultsmentioning

confidence: 99%

Aetiology of neonatal sepsis in Nigeria, and relevance of Group b streptococcus: A systematic review

et al. 2018

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BackgroundGroup B Streptococcus (GBS) causes invasive infections in neonates and has been implicated as a cause of prelabour rupture of membranes, preterm delivery and stillbirths. The success of phase II trials of polyvalent polysaccharide GBS vaccines indicates that these infections are potentially preventable. Nigeria is the most populous country in Africa with one of the highest birth rates, one of the highest neonatal sepsis incidence rates and one of the highest mortality rates in the world. Therefore, before the possible introduction of preventive strategies such as intrapartum antibiotic prophylaxis or GBS vaccine into Nigeria, it is vital that there is accurate data on the aetiology of neonatal sepsis and on the incidence of GBS neonatal sepsis in particular. The objective of this study was to determine the incidence and aetiology of neonatal sepsis in Nigeria with a focus on GBS sepsis and also to assess the potential impact of a GBS vaccine.MethodsA literature search was conducted on the databases of African journals online, PubMed and Google Scholar for works conducted between 1987 to 2017. Case reports, reviews, and studies not stating specific culture methods or specific bacteria isolated were excluded. Data extracted included; incidence of neonatal sepsis, method of blood culture, blood volume, sample size, bacterial agents isolated and history of antibiotic use. PRISMA guidelines were followed and modified Down’s and Black criteria used to evaluate the quality of studies.ResultsA total of 5,114 studies were reviewed for neonatal sepsis out of which 24 consisting of a total of 2,280 cases were selected for final review. Nine studies met criteria for assessment of hospital based incidence of neonatal sepsis representing 31,305 hospital births. The incidence of neonatal sepsis was 18.2/1000 livebirths with range from 7-55/1000 livebirths while the GBS incidence was 0.06/1000 livebirths with range from 0-2/1000 live births. We discovered various limitations such as identification techniques that could result in underestimation of the true incidence of GBS sepsis. Pathogens such as Klebsiella pneumoniae and Staphylococcus aureus were more commonly isolated than GBS.Implications of key findingsThe hospital based incidence of neonatal sepsis was high at 18.2/1000 live births while that due to GBS was 0.06/1000 live births. The burden of neonatal sepsis, including that attributable to GBS is substantial and could be reduced by preventive strategies such as intrapartum antibiotic prophylaxis or GBS vaccine. There is however very sparse meaningful data currently. Well planned prospective studies with larger sample sizes, more advanced isolation and identification techniques and those following up invasive disease cases for possible short and long term sequelae are needed—not only prior to possible introduction of the vaccine to determine the baseline epidemiology, but also thereafter to monitor its impact on the population. Strategies need to be developed to also reduce the morbidity and mortality attributa...

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“…[11] For studies that did not specify antibioitics sensitivity and resistance pattern per organism, Ciprofloxacin 4+ was still among the most sensitive drug followed by Ceftriaxone 2+, Chloramphenicol 2+ and Cefuroxime 2+ (Table 4). [11,13,16,18]…”

Section: Resultsmentioning

confidence: 99%

Bacterial Profile and Antibiogram of Neonatal Sepsis in Nigeria; A Review of Literatures

Ekwochi¹

2020

Anatol JFM

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Neonatal Septicaemia in a Rural Nigerian Hospital: Aetiology, Presentation and Antibiotic Sensitivity Pattern

Cited by 10 publications

References 7 publications

Unfinished agenda of the neonates in developing countries: magnitude of neonatal sepsis: systematic review and meta-analysis

Unfinished agenda of the neonates in developing countries: magnitude of neonatal sepsis: systematic review and meta-analysis

Aetiology of neonatal sepsis in Nigeria, and relevance of Group b streptococcus: A systematic review

Bacterial Profile and Antibiogram of Neonatal Sepsis in Nigeria; A Review of Literatures

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