Neonatal Septicemia: Bacteriology and Risk Factors in a Tertiary Care Hospital of Central India

Riti, J. Seth; Lazarus, Monica

doi:10.20546/ijcmas.2018.704.145

Cited by 2 publications

(1 citation statement)

References 6 publications

(7 reference statements)

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“…18,19 After analyzing birth weight of culture proven cases of neonatal sepsis, it was found that near about 53% belong to Low birth weight and 31% in very low birth weight group while in 2 cases birth weight was less than 1000gram. This suggest association low birth weight with neonatal sepsis, which was also observed other studies carried out by Jajoo M et al & Seth Riti J et al 20,21 WHO has defined low birth weight neonate as any neonate weighing less than 2500 g at birth. The incidence of low birth weight neonates in India is 16% to 30% taking 2500g.…”

Section: Results and Observationssupporting

confidence: 79%

Etiological divergence and antimicrobial susceptibility pattern among culture proven cases of neonatal sepsis from a tertiary care teaching institute in a konkan region of Maharashtra

Shelke¹,

Nakate²,

Patil³

et al. 2020

IJMMTD

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Neonatal mortality is one of the major obstacle to achieve present days health goals of world health organization & neonatal sepsis is important preventable causes behind neonatal mortality all over the world. Analysis of etiology of neonatal sepsis and antimicrobial susceptibility pattern among isolates helps in implementation of antimicrobial policy in NICU for rational empirical antibiotics. Aim and Objectives: This study was carried out to analyze etiology, the change in trends in bacteriological agents of neonatal sepsis & also studying antimicrobial susceptibility pattern in these different isolates during study period. Materials and Methods: This is a retrospective observational study. In this study all the records of blood culture samples taken from suspected neonatal sepsis cases in NICU & which are received & processed in Microbiology department are analyzed, during January 2017 to August 2019.Results: Total 400 blood culture reports were analyzed from 400 suspected neonatal sepsis cases, out of that 98 were pure growth indicating 24.50% culture positivity. In these cases of neonatal sepsis 57 were male & 41 were female. These newborn with sepsis had risk factors like preterm neonates (55.10%) low birth weight (53.06%) & Birth asphyxia (31.63%). Though there was Year wise variation observed in etiological agents of neonatal sepsis Overall 77(78.57%) isolates were gram negative organism & The most common etiological agent of neonatal sepsis was Pantoea Species (25 isolates) followed by Klebsiella species (24 isolates). It was observed that against antimicrobial agent's like ceftazidime, ceftazidime clavunic acid, cefoperazone, piperacillin tazobactum, ampicillin & cefoperazone sulbactum gram negative isolates showed marked resistance. While gram positive isolates showed resistance towards penicillin, cefoxitin, azithromycin & calirithromycin. High Mortality 25.51% was seen in culture proven cases of neonatal sepsis. Conclusion:We observed year wise variations in etiology of neonatal sepsis during study duration which point out need of continuous monitoring and surveillance to prevent morbidity and mortality of neonatal sepsis in konkan region.

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Section: Results and Observationssupporting

confidence: 79%

Etiological divergence and antimicrobial susceptibility pattern among culture proven cases of neonatal sepsis from a tertiary care teaching institute in a konkan region of Maharashtra

Shelke¹,

Nakate²,

Patil³

et al. 2020

IJMMTD

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The changing bacteriological profile of neonatal sepsis in a tertiary care hospital – Emergence of Citrobacter septicemia

Nirmal¹,

Gupta

Singh³

et al. 2023

IJMMTD

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Neonatal Mortality Rate (NMR) is one of the indicators of health status of a nation and neonatal sepsis is one of the commonest causes of NMR contributing to 19% of all neonatal deaths in India. All over India, there is a gradually increasing trend of multi-drug resistant (MDR) pathogens in neonatal intensive care units (NICU) and special newborn care units (SNCUs) in tertiary care hospitals.To determine the changing trend in the bacteriological profile of neonatal septicemia and their antibiotic susceptibility pattern (AST).It is a retrospective study conducted on total 452 blood culture samples collected from SNCU over 1-year period from July 2017 to June 2018 in tertiary care government hospital. Organisms were identified by the standard protocol and their antimicrobial susceptibility testing was determined as per latest CLSI guidelines.out of 452 blood culture of neonatal septicemia patients, 138 cases (30.53%) were culture positive Most common isolated gram negative organism was spp. 55/138 (39.85%) followed by spp. 23/138 (16.66%). Most common isolated gram positive organism was 25/138 (18.11%) followed by Coagulase Negative Staphylococcus (CONS) (8.69%). Among gram negative isolates most sensitive antimicrobial was Imipenem (87.6%) followed by Levofloxacin (87.4%) and Piperacillin + Tazobactam (46%) and resistant to, Cotrimoxazole, Amoxicillin + clavulanate and 3rd generation Cephalosporins.spp. is the predominant organism of neonatal sepsis in the Indian subcontinent, although significant rise in proportion of spp. is occurring. High resistance to cephalosporins is a cause of concern, as they are one of the most common prescribed antibiotic groups.

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Neonatal Septicemia: Bacteriology and Risk Factors in a Tertiary Care Hospital of Central India

Cited by 2 publications

References 6 publications

Etiological divergence and antimicrobial susceptibility pattern among culture proven cases of neonatal sepsis from a tertiary care teaching institute in a konkan region of Maharashtra

Etiological divergence and antimicrobial susceptibility pattern among culture proven cases of neonatal sepsis from a tertiary care teaching institute in a konkan region of Maharashtra

The changing bacteriological profile of neonatal sepsis in a tertiary care hospital – Emergence of Citrobacter septicemia

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