Neonatal short-term outcomes in infants with intrauterine growth restriction

Hășmășanu, Monica; Bolboacă, Sorana D.; Baizat, Melinda; Drugan, Tudor; Zaharie, Gabriela

doi:10.15537/smj.2015.8.11533

Cited by 15 publications

(9 citation statements)

References 19 publications

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“…Metabolic morbidities, such as neonatal hypoglycemia, hypocalcemia, or hyperbilirubinemia requiring phototherapy, are more common in late preterm births compared to full term births [3]. Our results show that the rate of hypoglycemia was higher in the iLPTB group than in the sLPTB group, without differences in the GDM rate [17] [18].…”

Section: Discussionmentioning

confidence: 56%

Comparison of Perinatal Outcomes in Late Preterm Spontaneous and Indicated Preterm Birth Neonates

Chun¹,

Yoo²,

Lee³

et al. 2016

OJOG

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Objective: We aimed to compare the perinatal outcomes in late preterm spontaneous and indicated birth neonates. Methods: We studied 289 late preterm births, classified as either aspontaneous late preterm birth (sLPTB) group (preterm labor with intact membranes and preterm premature rupture of membranes) or an indicated late preterm birth (iLPTB) group (hypertensive disorder in pregnancy, placental causes, and maternal diseases), according to the delivery indication. We then compared the maternal and neonatal characteristics and perinatal outcomes, including the Apgar score, admission to the neonatal intensive care unit (NICU) or special care nursery (SCN), duration of NICU stay, and the rate of composite morbidity (antibiotic use, hypoglycemia, hypocalcemia, hyperbilirubinemia requiring phototherapy, respiratory support, and respiratory distress syndrome). Results: A total of 198 neonates were in the sLPTB group and 91 were in the iLPTB group. In spite of greater gestational age at the time of delivery in the iLPTB group, the mean birth weight was lower than that in the sLPTB group. Additionally, the iLPTB group showed lower Apgar scores, and higher rates of NICU or SCN admission, respiratory support, and hypoglycemia, but there was no difference in the rate of composite morbidity between the two groups. Conclusion: iLPTB neonates had lower birth weights despite greater gestational age than those in the sLPTB group, but there was no difference in the rate of composite morbidity between the two groups.

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Section: Discussionmentioning

confidence: 56%

Comparison of Perinatal Outcomes in Late Preterm Spontaneous and Indicated Preterm Birth Neonates

Chun¹,

Yoo²,

Lee³

et al. 2016

OJOG

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“…Hasmasanu et al conducted a study in 2013 which revealed that 27.3% of the IUGR neonates developed hypoglycemia while 4.3% of the AGA babies did so. 13 Similarly, Mazumder et al studied the correlation of hypoglycemia in IUGR neonates and observed a much higher incidence (46.9%) compared to 3.1% among term AGA neonates. 8 Lubchenco et al found that 25% of term IUGR neonates presented with hypoglycemia compared to 10% among term AGA neonates.…”

Section: Discussionmentioning

confidence: 97%

A comparative study of blood glucose and serum calcium levels in term IUGR neonates and normal neonates: a cross sectional study

Konded

Koppad

2018

Int J Contemp Pediatr

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Background: Hypoglycemia and hypocalcemia are common metabolic problems occurring in the newborn and have direct consequences in the early neonatal period, prompt identification and treatment prevents severe neurodevelopmental outcomes. The primary objective was to compare blood glucose and serum calcium levels in term Intrauterine growth restriction (IUGR) babies with term appropriate for age (AGA) babies and secondarily to compute number of term IUGR babies with hypoglycemia and hypocalcemia.Methods: Fifty term IUGR and 50 term AGA babies delivered at SDMCMSH, Dharwad during the study period of one year were included as cases and controls respectively after considering the inclusion and exclusion criteria. Two ml of peripheral venous blood was analyzed at 3 hours and 24 hours of life. Serum calcium was measured by calorimetric test method and blood glucose by auto analyzer. Statistical analysis was done using SPSS-17.Results: At 3 hours of birth, 24% of term IUGR and 4% of AGA neonates had hypoglycemia. The mean RBS of cases at 3rd hour was 61.36±23.56 mg/dl, significantly lower than control group (75.90±22.57mg/dl). The mean RBS among cases at 24 hours of life was 70.42±16.14 mg/dl compared to 78.84±15.90 mg/dl among controls. Both correlations were statistically significant. 8% cases had hypocalcemia at 3 hours and 6% had at 24 hours. The mean serum calcium level was lower in cases (8.50±1.40 mg/dl) than controls (8.63±1.14 mg/dl) at the 3rd hour of life and 24 hours of life [cases (8.42±1.07 mg/dl) versus controls (8.64±0.91 mg/dl)].Conclusions: Significantly lower blood glucose levels were identified in term IUGR neonates. This association was apparent at 3 hours of life. The measurement of serum calcium & glucose in IUGR babies could predict a poorer outcome in these patients. Identifying and treating these biochemical abnormalities can avoid short term as well as long term sequelae.

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“…Some studies 23 reported no association of neonatal brain injury with IUGR, whereas others found significantly higher percentage of infants with intraventricular hemorrhage in the IUGR group compared with controls. 24 Also, the effect of chorioamnionitis on ICH is not straightforward. 25 While some findings indicated no association 26 between chorioamnionitis and intraventricular hemorrhage, others recognized chorioamnionitis as a risk factor of intraventricular hemorrhage.…”

Section: Discussionmentioning

confidence: 99%

Postnatal Paraclinical Parameters Associated to Occurrence of Intracerebral Hemorrhage in Preterm Infants

et al. 2019

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Intracerebral hemorrhage (ICH) is the most frequent complication in postnatal development of preterm infants. The purpose of the present work is the statistical evaluation of seven standard paraclinical parameters and their association to the development of ICH. Clinical records of 265 preterm infants with gestational age (GA) 23 to 30 weeks were analyzed. According to ICH status, patients were divided into control (without ICH) and affected (with ICH) groups. Mean values of paraclinical parameters at each week of gestation were compared. Different ICH grades, periods before and after ICH were considered separately. Lower hematocrit, SaO2, and pH were statistically significant for preterm infants with 23 to 30 weeks GA and diagnosis of ICH relative to infants without ICH. Additionally, for preterm infants with 27 to 30 weeks GA, higher C-reactive protein, as well as lower values of thrombocytes were associated with the occurrence of ICH. Preterm infants with 23 to 26 weeks GA showed C-reactive protein values similar to those in the group without ICH and lower levels of thrombocytes after bleeding. Significant differences in paraclinical parameters between preterm infants with and without ICH may constitute useful indicators for closer clinical observation of preterm infants at risk of ICH.

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Neonatal short-term outcomes in infants with intrauterine growth restriction

Cited by 15 publications

References 19 publications

Comparison of Perinatal Outcomes in Late Preterm Spontaneous and Indicated Preterm Birth Neonates

Comparison of Perinatal Outcomes in Late Preterm Spontaneous and Indicated Preterm Birth Neonates

A comparative study of blood glucose and serum calcium levels in term IUGR neonates and normal neonates: a cross sectional study

Postnatal Paraclinical Parameters Associated to Occurrence of Intracerebral Hemorrhage in Preterm Infants

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