Neonatal thrombocytopenia: What we do and don't know

Sola‐Visner, Martha; Saxonhouse, Matthew A.; Brown, Rachel E.

doi:10.1016/j.earlhumdev.2008.06.004

Cited by 100 publications

(93 citation statements)

References 14 publications

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“…Several studies have reported thrombocytopenia in 22-35% in all infants admitted to the neonatal intensive care unit. 6,7 Despite its high prevalence, several basic patho-physiologic questions regarding neonatal thrombocytopenia remain unsolved.…”

Section: Discussionmentioning

confidence: 99%

Incidence of thrombocytopenia in the neonatal intensive care unit

Gupta¹,

Mathai

Kanitkar

2011

Medical Journal Armed Forces India

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Section: Discussionmentioning

confidence: 99%

Incidence of thrombocytopenia in the neonatal intensive care unit

Gupta¹,

Mathai

Kanitkar

2011

Medical Journal Armed Forces India

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“…Previous studies report a prevalence of thrombocytopenia of 1-5% of all newborns and may develops in 18% to 35% of NICU patients [5,6]. Thrombocytopenia is defined as platelet count <150,000/mm 3 regardless of the gestational age.…”

Section: Introductionmentioning

confidence: 99%

Incidence of Thrombocytopenia in Idiopathic Hyperbilirubinemic Newborns

Boskabadi

Mafinezhad

Bagher

et al. 2014

Open Access Maced J Med Sci

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Background: Hyperbilirubinemia is the most common reason for admission during the neonatal period and may develop serious complications. Thrombocytopenia is defined as platelet count <150,000/mm 3 and has not been conclusively reported as a complication of hyperbilirubinemia in any of the standard paediatric textbooks. The aim of this study was to find the incidence of thrombocytopenia in neonates with idiopathic jaundice and the relationship between hyperbilirubinaemia and platelet count.

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“…This study provides a platform for identifying potential covariates that influence the interindividual variability in model parameters regulating IPF and PLT kinetics and for evaluating future pharmacological therapies for treating thrombocytopenic neonates. neonatal thrombocytopenia; immature platelet fraction; platelets; transit compartment model NEONATAL THROMBOCYTOPENIA is a common hematological disorder, and ϳ22-35% of all neonates admitted to the neonatal intensive care unit suffer from this condition (22,27). Premature very low birth weight (VLBW, Ͻ1,500 g at birth) neonates are more often affected, as the incidence of thrombocytopenia is inversely proportional to gestational age.…”

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confidence: 99%

“…Consequently, a majority of neonates affected by thrombocytopenia receive prophylactic PLT transfusions (22,27). This practice of frequent PLT transfusions puts neonates at risk of experiencing transfusionrelated complications, including viral or bacterial infections, transfusion-related lung injury, circulatory overload, or immune-mediated transfusion reactions (30).…”

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confidence: 99%

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Mathematical model of platelet turnover in thrombocytopenic and nonthrombocytopenic preterm neonates

Kulshrestha

Sola‐Visner

Widness

et al. 2015

American Journal of Physiology-Heart and Circulatory Physiology

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Kulshrestha M, Sola-Visner M, Widness JA, Veng-Pedersen P, Mager DE. Mathematical model of platelet turnover in thrombocytopenic and nonthrombocytopenic preterm neonates. Am J Physiol Heart Circ Physiol 308: H68 -H73, 2015. First published October 31, 2014 doi:10.1152/ajpheart.00528.2013.-Neonatal thrombocytopenia affects 22-35% of all neonates admitted to neonatal intensive care units. The purpose of this study was to develop a mathematical model for characterizing platelet (PLT) kinetics in thrombocytopenic preterm neonates. Immature PLT fraction (IPF) and PLT counts were measured for up to 35 days after birth in 27 very low birth weight preterm neonates. PLT transfusions were administered to 8 of the 27 (24%) subjects. The final model included a series of four transit compartments to mimic the production and survival of IPF and PLT. Model parameters were estimated using nonlinear mixed effects modeling with the maximum likelihood expectation maximization algorithm. The model adequately captured the diverse phenotypes expressed by individual subject profiles. Typical population survival values for IPF and PLT life spans in nonthrombocytopenic patients were estimated at 0.912 and 10.7 days, respectively. These values were significantly shorter in thrombocytopenic subjects, 0.429 and 2.56 days, respectively. The model was also used to evaluate the influence of growth and laboratory phlebotomy loss on the time course of IPF and PLT counts. Whereas incorporating body weight was essential to correct for expanding blood volume due to growth, phlebotomy loss, a possible covariate, did not significantly influence PLT kinetics. This study provides a platform for identifying potential covariates that influence the interindividual variability in model parameters regulating IPF and PLT kinetics and for evaluating future pharmacological therapies for treating thrombocytopenic neonates. neonatal thrombocytopenia; immature platelet fraction; platelets; transit compartment model NEONATAL THROMBOCYTOPENIA is a common hematological disorder, and ϳ22-35% of all neonates admitted to the neonatal intensive care unit suffer from this condition (22,27). Premature very low birth weight (VLBW, Ͻ1,500 g at birth) neonates are more often affected, as the incidence of thrombocytopenia is inversely proportional to gestational age. Traditionally, the definition of thrombocytopenia in neonates of all gestational ages is the same as in adults, namely a platelet (PLT) count of Ͻ150 ϫ 10 3 /l based on fetuses in the second trimester having PLT counts within the normal adult range (13).The underlying general mechanisms responsible for neonatal thrombocytopenia are similar to adults, namely, increased PLT destruction, decreased PLT production, PLT sequestration, or a combination of these processes (27). However, it is more difficult to identify causes of neonatal thrombocytopenia as the diagnosis can be challenging owing to the dynamic nature of newborn development and technical difficulties associated with performing certain diagnostic tests i...

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Neonatal thrombocytopenia: What we do and don't know

Cited by 100 publications

References 14 publications

Incidence of thrombocytopenia in the neonatal intensive care unit

Incidence of thrombocytopenia in the neonatal intensive care unit

Incidence of Thrombocytopenia in Idiopathic Hyperbilirubinemic Newborns

Mathematical model of platelet turnover in thrombocytopenic and nonthrombocytopenic preterm neonates

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