Neonatal thrombosis: risk factors and principles of prophylaxis

Воробьев, А. В.; Бицадзе, В. О.; Khizroeva, J. Kh.; Potapkina, S. A.; Makatsariya, N. A.; Rizzo, Giuseppe; Renzo, Gian Carlo Di; Блинов, Д. В.; Pankratyeva, L. L.; Цибизова, В. И.

doi:10.17749/2313-7347/ob.gyn.rep.2021.233

Cited by 4 publications

(2 citation statements)

References 62 publications

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“…Thrombotic thrombocytopenic purpura (TTP), caused by ADAMTS-13 gene congenital mutation, can also provoke the microvascular thrombosis development of platelet consumption [ 66 ]. Plasma ADAMTS-13 deficiency increases the level of von Willebrand factor (vWF) multimers.…”

Section: Neonatal Hemostasis System Peculiarities and Neonatal Thromb...mentioning

confidence: 99%

“…Plasma ADAMTS-13 deficiency increases the level of von Willebrand factor (vWF) multimers. The vWF/ADAMTS-13 axis dysfunction is considered as a risk factor in pediatric stroke and secondary microangiopathy development [ 66 ]. The vWF/ADAMTS-13 axis is involved in pathological clot formation, especially in neonates.…”

Section: Neonatal Hemostasis System Peculiarities and Neonatal Thromb...mentioning

confidence: 99%

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The Hemostatic System in Newborns and the Risk of Neonatal Thrombosis

Khizroeva,

Makatsariya,

Vorobev

et al. 2023

IJMS

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Newborns are the most vulnerable patients for thrombosis development among all children, with critically ill and premature infants being in the highest risk group. The upward trend in the rate of neonatal thrombosis could be attributed to progress in the treatment of severe neonatal conditions and the increased survival in premature babies. There are physiological differences in the hemostatic system between neonates and adults. Neonates differ in concentrations and rate of synthesis of most coagulation factors, turnover rates, the ability to regulate thrombin and plasmin, and in greater variability compared to adults. Natural inhibitors of coagulation (protein C, protein S, antithrombin, heparin cofactor II) and vitamin K-dependent coagulation factors (factors II, VII, IX, X) are low, but factor VIII and von Willebrand factor are elevated. Newborns have decreased fibrinolytic activity. In the healthy neonate, the balance is maintained but appears more easily converted into thrombosis. Neonatal hemostasis has less buffer capacity, and almost 95% of thrombosis is provoked. Different triggering risk factors are responsible for thrombosis in neonates, but the most important risk factors for thrombosis are central catheters, fluid fluctuations, liver dysfunction, and septic and inflammatory conditions. Low-molecular-weight heparins are the agents of choice for anticoagulation.

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Section: Neonatal Hemostasis System Peculiarities and Neonatal Thromb...mentioning

confidence: 99%

Section: Neonatal Hemostasis System Peculiarities and Neonatal Thromb...mentioning

confidence: 99%

The Hemostatic System in Newborns and the Risk of Neonatal Thrombosis

Khizroeva,

Makatsariya,

Vorobev

et al. 2023

IJMS

Self Cite

View full text Add to dashboard Cite

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Pediatric antiphospholipid syndrome: is it the same as an adult?

Bitsadze,

Khizroeva,

Lazarchuk

et al. 2024

The Journal of Maternal-Fetal & Neonatal Medicine

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Intracranial hemorrhage during pregnancy

Bayalieva

Davydova

Mohsin

et al. 2022

Akušerstvo, ginekologiâ i reprodukciâ

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Here, we review publications aimed at assessing the prevalence of intracranial hemorrhage, types of hemorrhage in pregnant patients, diagnostic features, as well as the basic principles of treatment used in such cases. There a represented pathologies in pregnant women such as subarachnoid, subdural, extradural hemorrhage, thrombosis of cavernous sinuses, arteriovenous malformations, neoplasms. There are summarized data within the years from 2015 to 2020 retrieved from the search databases PubMed/MEDLINE, Google Scholar, and Web of Science. Based on our study, it was concluded that intracranial hemorrhages during pregnancy most often occur in the third trimester. This is due to several factors: development of preeclampsia, increased blood pressure, coagulopathy, HELLP-syndrome, physiological remodeling of cerebral autoregulation, and concomitant initial pathology of cerebral vessels such as aneurysms and arteriovenous malformations. We also draw special attention to the importance of timely differential diagnostics of hypertensive conditions during preeclampsia and neurosurgical pathology requiring urgent intervention.

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Neonatal thrombosis: risk factors and principles of prophylaxis

Cited by 4 publications

References 62 publications

The Hemostatic System in Newborns and the Risk of Neonatal Thrombosis

The Hemostatic System in Newborns and the Risk of Neonatal Thrombosis

Pediatric antiphospholipid syndrome: is it the same as an adult?

Intracranial hemorrhage during pregnancy

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