Neonatal treatment with para-chlorophenylalanine (pCPA) induces adolescent hyperactivity associated with changes in the paraventricular nucleus Crh and Trh expressions

Trujillo, Verónica; Camilo, Tays Araújo; Valentim-Lima, Evandro; Carbalan, Quézia S.R.; Dos-Santos, Raoni C.; Felintro, Viviane; Reis, Luís C.; Lustrino, Danilo; Rorato, Rodrigo; Mecawi, André S.

doi:10.1016/j.bbr.2024.114867

Behavioural Brain Research

2024

DOI: 10.1016/j.bbr.2024.114867

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Neonatal treatment with para-chlorophenylalanine (pCPA) induces adolescent hyperactivity associated with changes in the paraventricular nucleus Crh and Trh expressions

Verónica Trujillo,

Tays Araújo Camilo,

Evandro Valentim-Lima

et al.

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Early‐life manipulation of the serotonergic system exacerbates the harmful effects of sleep deprivation on cognitive functions

Mashahadi,

Saadati,

Ghaheri Fard

2024

Intl J of Devlp Neuroscience

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Serotonin is a monoamine neurotransmitter that plays a main role in regulating physiological and cognitive functions. Serotonergic system dysfunction is involved in the etiology of various psychiatric and neurological disorders. Therefore, the present study was designed to investigate the effects of early‐life serotonin depletion on cognitive disorders caused by sleep deprivation. Serotonin was depleted by para‐chlorophenylalanine (PCPA, 100 mg/kg, s.c.) at postnatal days 10–20, followed by sleep deprivation‐induced through the multiple platform apparatus for 24 h at PND 60. After the examination of the novel object recognition and passive avoidance memories, the hippocampi and prefrontal cortex were dissected to examine the brain‐derived neurotrophic factor (BDNF) mRNA expression by PCR. Our findings showed that postnatal serotonin depletion and sleep deprivation impaired the novel object recognition and passive avoidance memories and changed the BDNF levels. In the same way, the serotonin depletion in early life before sleep deprivation exacerbated the harmful effects of sleep deprivation on cognitive function and BDNF levels. It can be claimed that the serotonergic system plays a main role in the modulation of sleep and cognitive functions.

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Early‐life manipulation of the serotonergic system exacerbates the harmful effects of sleep deprivation on cognitive functions

Mashahadi,

Saadati,

Ghaheri Fard

2024

Intl J of Devlp Neuroscience

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show abstract

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Neonatal treatment with para-chlorophenylalanine (pCPA) induces adolescent hyperactivity associated with changes in the paraventricular nucleus Crh and Trh expressions

Cited by 1 publication

References 70 publications

Early‐life manipulation of the serotonergic system exacerbates the harmful effects of sleep deprivation on cognitive functions

Early‐life manipulation of the serotonergic system exacerbates the harmful effects of sleep deprivation on cognitive functions

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