Neonatal tumours

Lakhoo, Kokila; Sowerbutts, Helen

doi:10.1007/s00383-010-2738-7

Cited by 29 publications

(45 citation statements)

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“…While this is a very rough estimation, we can propose that actually neonatal cancer cases were much less frequent in the population as the Ali-Asghar hospital is one of very few referral centers for neonatal and pediatric cancer in Iran. In the Third National (US) Cancer Survey (TNCS), Bader and Miller estimated the prevalence of malignancy in the first month of life to be 36 per million live births, or about 1:27000, while a report from the British Pediatric Pathology Society estimated the prevalence of congenital neoplasia (benign and malignant) between 1:12500 and 1:17300 total births (Lakhoo et al, 2010;Moore et al, 2003). It appears noteworthy that the majority of tumors are sporadic mesenchymal and embryonic in nature (carcinomas being virtually absent), which is similar to reported tumors identified in newborn calves in Europe, suggesting similar causative mechanisms.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Epidemiologic Survey of Infantile Cancer in Iran based on the Data of the Largest Pediatric Cancer Referral Center (Ali-Asghar Children Hospital), 1996-2005

Bahoush

Habibi²,

Shariftabrizi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Cancer in infants younger than one year of age represents a unique problem with distinct epidemiological, clinical and genetic characteristics compared with older age groups. No report is yet available from Iran regarding epidemiological and survival rate of cancers diagnosed in this age group. Materials and Methods: The population under study comprised of patients which were diagnosed and admitted to Ali-Asghar hospital between years 1996-2005. In total, 287 infants were included in the retrospective descriptive survey. Patient files were evaluated for age of patient at the time of diagnosis, sex, geographical residence, consanguinity of parents, histological diagnosis, site of cancer involvement, type of therapy, date of last follow-up and cause of death (if applicable). Results: The average age at the time of diagnosis was 7.2 months old. The most frequent malignancy was retinoblastoma (44%), followed by leukemia (19%) and neuroblastoma (10%), with five-year overall survival rates of 77.7%, 41% and 90%, respectively Parents of 40 infants (13.9%) had consanguinity relationships. Conclusions: Although we cannot make any conclusions regarding the incidence of infant cancer subtypes based on this study, survival rates for major types were similar to the developed countries, which signifies strict adherence to standards of care in Ali-Asghar hospital, the main infant cancer care centre in Iran. A Childhood Cancer Registry with high-resolution data collection and also advanced genetic testing is advocated for in-depth analysis of variation in incidence and survival.

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Section: Discussionmentioning

confidence: 99%

“…A variety of tumor types are noted in the neonatal period. Teratomas, especially of the sacrococcygeal region, were most commonly reported followed by neuroblastoma and soft tissue tumors (Lakhoo et al, 2010;Moore et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Epidemiologic Survey of Infantile Cancer in Iran based on the Data of the Largest Pediatric Cancer Referral Center (Ali-Asghar Children Hospital), 1996-2005

Bahoush

Habibi²,

Shariftabrizi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Although most affected children have no associated abnormality, associations have been described for both histologic variants [ 182 ].…”

Section: Congenital Mesoblastic Nephromamentioning

confidence: 99%

Perinatal Tumors

Azizkhan¹,

Allmen²

2016

The Surgery of Childhood Tumors

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“…Teratomas, derived from pluripotent cells, are the most common neonatal tumors and are mainly located in the sacrococcygeal region or mediastinum [3]. They commonly present as large and deforming monstrous tumors with an incidence of 1 in 20,000 to 40,000 newborns.…”

Section: Introductionmentioning

confidence: 99%

“…These lesions contain all three germ layers and may be composed of mature or immature elements. In the neonate, the presence of immature elements does not correlate with malignant potential, and most of these teratomas are benign [1,3,6,12,13].…”

Section: Introductionmentioning

confidence: 99%