Neonatal vitamin D status and risk of multiple sclerosis

Nielsen, Nete Munk; Munger, Kassandra L.; Koch‐Henriksen, Nils; Hougaard, David M.; Magyari, Melinda; Jørgensen, Kristian Tore; Lundqvist, Marika; Simonsen, Jacob; Jess, Tine; Cohen, Arieh; Stenager, Egon; Ascherio, Alberto

doi:10.1212/wnl.0000000000003454

Cited by 122 publications

(70 citation statements)

References 38 publications

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“…Another possible explanation for our findings is the seasonal variation of ultraviolet B light radiation and vitamin D status during gestation . A Danish study recently found an inverse relation between the neonatal vitamin D status and the development of MS later in life, indicating that in utero exposure to vitamin D could be relevant with regard to the development of autoimmunity . The finding of an increased risk of AIT later in life when born during the summer could partly be explained by lower levels of vitamin D in utero during the winter and should be explored in this context …”

Section: Discussionmentioning

confidence: 86%

Month of birth is associated with the subsequent diagnosis of autoimmune hypothyroidism. A nationwide Danish register‐based study

Thvilum

Brandt

Brix

2017

Clinical Endocrinology

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Section: Discussionmentioning

confidence: 86%

Month of birth is associated with the subsequent diagnosis of autoimmune hypothyroidism. A nationwide Danish register‐based study

Thvilum

Brandt

Brix

2017

Clinical Endocrinology

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“…The exact cause of multiple sclerosis (MS), a chronic inflammatory and neurodegenerative autoimmune disease of the central nervous system (1) is unknown. However, several environmental and genetic factors have been associated with MS pathogenesis, among them are vitamin D (VD) serum levels (2)(3)(4)(5), vitamin D receptor polymorphisms (VDP) (6)(7)(8)(9)(10), and sunlight exposure (11,12). In fact, increasing evidence suggests that VD deficiency may affect disease progression and outcome in MS.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D and Disease Severity in Multiple Sclerosis—Baseline Data From the Randomized Controlled Trial (EVIDIMS)

et al. 2020

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Objective: To investigate the associations between hypovitaminosis D and disease activity in a cohort of relapsing remitting multiple sclerosis (RRMS) and clinically isolated syndrome (CIS) patients. Methods: In 51 RRMS and 2 CIS patients on stable interferon-β-1b (IFN-β-1b) treatment recruited to the EVIDIMS study (Efficacy of Vitamin D Supplementation in Multiple Sclerosis (NCT01440062) baseline serum vitamin D levels were evaluated. Patients were dichotomized based on the definition of vitamin D deficiency which is reflected by a < 30 vs. ≥ 30 ng/ml level of 25-hydroxyvitamin D (25(OH)D). Possible associations between vitamin D deficiency and both clinical and MRI features of the disease were analyzed. Results: Median (25, 75% quartiles, Q) 25(OH)D level was 18 ng/ml (12, 24). Forty eight out of 53 (91%) patients had 25(OH)D levels < 30 ng/ml (p < 0.001). Patients with 25(OH)D ≥ 30 ng/ml had lower median (25, 75% Q) T2-weighted lesion counts [25 (24, 33)] compared to patients with 25(OH)D < 30 ng/ml [60 (36, 84), p = 0.03; adjusted for age, gender and disease duration: p < 0.001]. Expanded disability status scale (EDSS) score was negatively associated with serum 25(OH)D levels in a multiple linear regression, including age, sex, and disease duration (adjusted: p < 0.001). Interpretation: Most patients recruited in the EVIDIMS study were vitamin D deficient. Higher 25(OH)D levels were associated with reduced T2 weighted lesion count and lower EDSS scores.

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“…However, no decrease in risk of MS was observed in the offspring exposed to high levels of 25(OH)D in utero (≥75 vs. <75 nmol/L) [221]. Nielsen et al also carried out a matched case-control study and found an association between lower levels of 25(OH)D in neonates and increased risk of MS [222]. However, in another population-based case-control study conducted in Sweden, Ueda et al failed to find such as association [223].…”

Section: Immunity and Allergiesmentioning

confidence: 99%

Maternal Vitamin D Status among Different Ethnic Groups and Its Potential Contribution to Adverse Pregnancy and Child Outcomes

Keshavarz¹,

Jandaghi²,

Shafiee³

et al. 2020

Vitamin D Deficiency

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Maternal vitamin D deficiency in pregnancy is a widespread public health concern. Race and ethnicity as biological and cultural factors, respectively, can affect vitamin D status through differences in skin color, sunlight exposure, and dietary intake. Low maternal vitamin D status in pregnancy may affect both mother and fetus adversely. Vitamin D deficiency and insufficiency are linked to a wide variety of adverse pregnancy outcomes such as gestational diabetes, preeclampsia, and preterm delivery. Furthermore, maternal vitamin D deficiency has been linked to several adverse health outcomes in infants and children. The examples include, but not limited to, impaired growth, skeletal problems, and autoimmune diseases such as type 1 diabetes and asthma. This chapter reviews the vitamin D status during pregnancy across different ethnic groups, looking into the adverse pregnancy and child outcomes, followed by a discussion on the association between maternal and child vitamin D status and successful interventions. Strong evidence exists about the association between vitamin D and some health outcomes during pregnancy, while more studies are needed to confirm the other claim. The existing body of evidence justifies the need for well-designed policies and systematic interventions to ensure optimal vitamin D status of pregnant women and their offsprings across different ethnic and racial groups.

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Neonatal vitamin D status and risk of multiple sclerosis

Cited by 122 publications

References 38 publications

Month of birth is associated with the subsequent diagnosis of autoimmune hypothyroidism. A nationwide Danish register‐based study

Month of birth is associated with the subsequent diagnosis of autoimmune hypothyroidism. A nationwide Danish register‐based study

Vitamin D and Disease Severity in Multiple Sclerosis—Baseline Data From the Randomized Controlled Trial (EVIDIMS)

Maternal Vitamin D Status among Different Ethnic Groups and Its Potential Contribution to Adverse Pregnancy and Child Outcomes

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