Neonatal Withdrawal Symptoms Associated With 'T's and Blues' (Pentazocine and Tripelennamine)

Dunn, David W.; Reynolds, Jane

doi:10.1001/archpedi.1982.03970430076024

Cited by 3 publications

(1 citation statement)

References 8 publications

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“…One such drug is pentazocine (Talwin) which, when used alone or in combination with other drugs such as tripelennamine citrate or codeine, can result in a neonatal withdrawal syndrome consisting of tremors, irritability, feeding difficulties, and hyperactivity, in addition to low birth weight and a high pitched cry [3][4][5][6]9,15]. Again, individual differences are found, so that an infant may appear to be unaffected by daily prenatal exposure, or when the drugs have been discontinued at least two months prior to birth [3]. In one case study an exposed infant who had exhibited neonatal symptoms appeared to be normal at one month of age [15].…”

Section: Introductionmentioning

confidence: 99%

Maternal Alcohol and Pentazocine Abuse: Neonatal Behavior and Morphology in an Opposite-Sex Twin Pair

Riese

1989

Acta genet. med. gemellol.: twin res.

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A pair of preterm, opposite-sex twins were examined during the lying-in period for behavioral and morphological effects of maternal alcohol and pentazocine abuse during pregnancy. A few morphological features typical of fetal alcohol syndrome were observed in each infant, and the male infant only was above the standardized mean in minor physical anomalies. The male's behavioral scores were more likely to be deviant from the standardized mean than the female's. Specifically, the male was more irritable, both spontaneously and in response to specific stimuli; highly active while awake and handled for the presentation of stimuli; more active than average during sleep; and low on ratings that reflect the attitude of the examiner toward the infant. These findings imply individual and gender differences in behavioral susceptibility to teratogens.

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