Neonate gut colonization: The rise of a social brain

Karaivazoglou, Katerina; Konstantakis, Christos; Assimakopoulos, Stelios F.; Triantos, Christos

doi:10.1111/nmo.13767

Cited by 2 publications

(2 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The transfer of commensal microbes from mother to offspring is now recognized as a critical perinatal event for many species, including humans (Karaivazoglou et al, 2020;J. Wang & Lin, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…The transfer of commensal microbes from mother to offspring is now recognized as a critical perinatal event for many species, including humans (Karaivazoglou et al., 2020; J. Wang & Lin, 2021). The peripartum period thus presents a distinct window of vulnerability given that administration of antibiotics (ABx) is common during this period (Bookstaver et al., 2015; Braye et al., 2018).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Maternal antibiotics disrupt microbiome, behavior, and temperature regulation in unexposed infant mice

Harshaw

Kojima

Wellman

et al. 2022

Developmental Psychobiology

View full text Add to dashboard Cite

Maternal antibiotic (ABx) exposure can significantly perturb the transfer of microbiota from mother to offspring, resulting in dysbiosis of potential relevance to neurodevelopmental disorders such as autism spectrum disorder (ASD). Studies in rodent models have found long‐term neurobehavioral effects in offspring of ABx‐treated dams, but ASD‐relevant behavior during the early preweaning period has thus far been neglected. Here, we exposed C57BL/6J mouse dams to ABx (5 mg/ml neomycin, 1.25 μg/ml pimaricin, .075% v/v acetic acid) dissolved in drinking water from gestational day 12 through offspring postnatal day 14. A number of ASD‐relevant behaviors were assayed in offspring, including ultrasonic vocalization (USV) production during maternal separation, group huddling in response to cold challenge, and olfactory‐guided home orientation. In addition, we obtained measures of thermoregulatory competence in pups during and following behavioral testing. We found a number of behavioral differences in offspring of ABx‐treated dams (e.g., modulation of USVs by pup weight, activity while huddling) and provide evidence that some of these behavioral effects can be related to thermoregulatory deficiencies, particularly at younger ages. Our results suggest not only that ABx can disrupt microbiomes, thermoregulation, and behavior, but that metabolic effects may confound the interpretation of behavioral differences observed after early‐life ABx exposure.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Maternal antibiotics disrupt microbiome, behavior, and temperature regulation in unexposed infant mice

Harshaw

Kojima

Wellman

et al. 2022

Developmental Psychobiology

View full text Add to dashboard Cite

show abstract

The bacterial neurometabolic signature of the gut microbiota of young children with autism spectrum disorders

Averina

Kovtun

Polyakova

et al. 2020

Journal of Medical Microbiology

View full text Add to dashboard Cite

Introduction. The human gut microbiota is currently seen as an important factor that can promote autism spectrum disorder (ASD) development in children. Aim. This study aimed to detect differences in the taxonomic composition and content of bacterial genes encoding key enzymes involved in the metabolism of neuroactive biomarker compounds in the metagenomes of gut microbiota of children with ASD and neurotypical children. Methodology. A whole metagenome sequencing approach was used to obtain metagenomic data on faecal specimens of 36 children with ASD and 21 healthy neurotypical children of 3–5 years old. Taxonomic analysis was conducted using MetaPhlAn2. The developed bioinformatics algorithm and created catalogue of the orthologues were applied to identify bacterial genes of neuroactive compounds in the metagenomes. For the identification of metagenomic signatures of children with ASD, Wilcoxon's test and adjustment for multiple comparisons were used. Results. Statistically significant differences with decreases in average abundance in the microbiota of ASD children were found for the genera Barnesiella and Parabacteroides and species Alistipes putredinis , B. caccae , Bacteroides intestinihominis, Eubacterium rectale , Parabacteroides distasonis and Ruminococcus lactaris . Average relative abundances of the detected genes and neurometabolic signature approach did not reveal many significant differences in the metagenomes of the groups that were compared. We noted decreases in the abundance of genes linked to production of GABA, melatonine and butyric acid in the ASD metagenomes. Conclusion. For the first time, the neurometabolic signature of the gut microbiota of young children with ASD is presented. The data can help to provide a comparative assessment of the transcriptional and metabolomic activity of the identified genes.

show abstract

Neonate gut colonization: The rise of a social brain

Cited by 2 publications

References 76 publications

Maternal antibiotics disrupt microbiome, behavior, and temperature regulation in unexposed infant mice

Maternal antibiotics disrupt microbiome, behavior, and temperature regulation in unexposed infant mice

The bacterial neurometabolic signature of the gut microbiota of young children with autism spectrum disorders

Contact Info

Product

Resources

About