Neonicotinoid concentrations in urine from chronic kidney disease patients in the North Central Region of Sri Lanka

Kabata, Risako; Nanayakkara, Shanika; Senevirathna, Lalantha; Harada, Kouji H.; Chandrajith, Rohana; Hitomi, Toshiaki; Abeysekera, Tilak; Takasuga, Takumi

doi:10.1539/joh.15-0140-br

Cited by 35 publications

(14 citation statements)

References 13 publications

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“…28 In a case control study, metabolites of neonicotinoid insecticides were shown to be lower in farmers with CKD compared to healthy controls living in Japan. 42 Aristolochic acid is a well-known nephrotoxin. 43 It's role in CKDu has not yet been evaluated adequately.…”

Section: Causative Factors -Human Studiesmentioning

confidence: 99%

Chronic kidney disease of unknown etiology in Sri Lanka

Rajapakse

Shivanthan²,

Selvarajah

2016

International Journal of Occupational and Environmental Health

124

109

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Evidence to date suggests that the disease is related to one or more environmental agents, however pinpointing a definite cause for CKDu is challenging. It is plausible that CKDu is multifactorial. No specific guidelines or recommendations exist for treatment of CKDu, and standard management protocols for CKD apply. Changes in agricultural practices, provision of safe drinking water, and occupational safety precautions are recommended by the World Health Organization.

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Section: Causative Factors -Human Studiesmentioning

confidence: 99%

Chronic kidney disease of unknown etiology in Sri Lanka

Rajapakse

Shivanthan²,

Selvarajah

2016

International Journal of Occupational and Environmental Health

124

109

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“…Biological monitoring has frequently detected imidacloprid in urine samples (Harada et al, 2016;Kabata et al, 2016;López-García et al, 2017;Ueyama et al, 2015;Ueyama et al, 2014;Yamamuro et al, 2014;Zhang et al, 2018); however, few studies have investigated its metabolites (Nomura et al, 2013;Uroz et al, 2001).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Urinary monitoring of neonicotinoid imidacloprid exposure to pesticide applicators

Yan

Phung

Dong

et al. 2019

Science of The Total Environment

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Neonicotinoid pesticides have recently drawn attention worldwide owing to their potential adverse effects on non-target organisms and ecosystems. Exposure to imidacloprid, the most widely used neonicotinoid insecticide, is of particular concern among rural populations because of its ubiquitous use in agriculture. Hence, biological monitoring of urinary imidacloprid and its major metabolite 6-chloronicotinic acid (6-CNA) was performed using Polar Enhanced Polymer solid-phase extraction by LC-MS/MS with mean recoveries of 78.3-109.8% and limits of quantitation at 0.029-0.038 ng/mL. Imidacloprid was detected in 100% of urine samples from rural applicators at concentrations of 0.21-8.91 ng/mL (0.06-9.60 μg/g creatinine) and 0.11-24.58 ng/mL (0.66-57.40 μg/g creatinine) before and after pesticide application, respectively. Significant increase in urine concentration (3.52to 3.77-fold) of imidacloprid and 6-CNA was observed after local imidacloprid field application (p ≤ 0.001). The estimated absorbed daily dose (ADD) for imidacloprid was 0.52-248.05 μg/kg/d, indicating that attention should be paid to potential health risks for applicators because of increased imidacloprid exposure at level of significance (p < 0.05). This study is the first to report ADD estimation for imidacloprid, thereby providing an important reference for further human health risk evaluation.

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“…; and in food matrices such as vegetables, fruits, honey and tea [4,10,19,23]. Also, some biomonitoring studies have consistently reported high detection frequencies of imidacloprid in human specimens and specimens from other non-target vertebrates [11,14,22,36,[39][40][41]46]. Despite these findings, little is known about the potential adverse health outcomes associated with chronic exposures to field realistic doses of imidacloprid in human populations.…”

Section: Introductionmentioning

confidence: 99%

Chronic low-dose exposure to imidacloprid potentiates high fat diet-mediated liver steatosis in C57BL/6J male mice

et al. 2021

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Hepatic steatosis is known to precede a continuum of events that lead to hepatic metabolic dysfunction, inflammation and carcinogenesis. Recently, studies have linked xenobiotic exposures to hepatic steatogenesis and its associated metabolic disorders; however, the underlying mechanisms remain elusive. This study aimed to elucidate the mechanistic role of imidacloprid in the prevalence of high fat diet (HFD)-induced liver steatosis, using a C57BL/6J mice model. Mice (3 weeks old) were fed with HFD and treated with 0.6 mg/kg bw/day (one-tenth of the NOAEL) of imidacloprid through water or diet, for 24 weeks. In a controlled group, mice were fed with only HFD. At the end of the study, imidacloprid treatment significantly potentiated HFD-induced body weight gain in mice. Also, imidacloprid increased the liver weights of mice, with complimentary reductions in mesenteric and gonadal white adipose tissue weights. Histopathological analysis of liver revealed a drastic steatosis in imidacloprid treated mice. Following a real-time qPCR analysis, imidacloprid upregulated transcriptions of hepatic fatty acid biosynthesis-related transcription factors and genes. Imidacloprid also induced hepatic expression of the gene encoding pregnane X receptor; but had no significant effect on hepatic expressions of liver X receptor and aryl hydrocarbon receptor. The imidacloprid treatment further enhanced serum alanine aminotransferase levels but downregulated hepatic antioxidant mRNA expressions. Ultimately, this study suggested an imidacloprid-potentiation effects on prevalence of HFD-induced liver steatosis via transcriptional modulations of the hepatic FA biosynthesis pathway.

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Neonicotinoid concentrations in urine from chronic kidney disease patients in the North Central Region of Sri Lanka

Abstract: samples from the general population of Japan. Conclusions: Farmers (both with and without CKDu) living in CKDu-endemic areas in the NCR of Sri Lanka are exposed to lower neonicotinoid concentrations than non-occupationally exposed residents of Japan. (J Occup Health 2016; 58: 128−133)

Cited by 35 publications

References 13 publications

Chronic kidney disease of unknown etiology in Sri Lanka

Chronic kidney disease of unknown etiology in Sri Lanka

Urinary monitoring of neonicotinoid imidacloprid exposure to pesticide applicators

Chronic low-dose exposure to imidacloprid potentiates high fat diet-mediated liver steatosis in C57BL/6J male mice

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