Neonicotinoid insecticides promote breast cancer progression via G protein-coupled estrogen receptor: In vivo, in vitro and in silico studies

Li, Xin; He, Sen; Han, Xiao; He, Ting-Ting; Zhang, Jia-Da; Luo, Zi-Rui; Ma, Jin; Yin, Yulong; Luo, Lin; Cao, Lin-Ying

doi:10.1016/j.envint.2022.107568

Cited by 11 publications

(9 citation statements)

References 60 publications

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“…These increase estradiol (E2) synthesis in adrenocortical carcinoma (H295R) and breast cancer (T47D) cells and increase cell proliferation via the estrogen receptors ERα and ERβ. These results indicate that even low concentrations and environmental levels of pesticides cause increased estrogen levels, which, at high levels, are related to potential risk factors for developing, especially, breast cancer in women (58,59,61,66).…”

Section: In Vitro and In Vivo Datamentioning

confidence: 82%

Monitoring residues of pesticides in food in Brazil: A multiscale analysis of the main contaminants, dietary cancer risk estimative and mechanisms associated

Valentim

Fagundes²,

Ferreira³

et al. 2023

Front. Public Health

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IntroductionPesticides pose a risk for cancer development and progression. People are continuously exposed to such substances by several routes, including daily intake of contaminated food and water, especially in countries that are highly pesticide consumers and have very permissive legislation about pesticide contamination as Brazil. This work investigated the relationship among pesticides, food contamination, and dietary cancer risk.MethodsAnalyzed two social reports from the Brazilian Government: the Program for Analysis of Residues of Pesticides in Food (PARA) and The National Program for Control of Waste and Contaminants (PNCRC).Results and discussionFirst, we characterized the main pesticide residues detected over the maximum limits allowed by legislation or those prohibited for use in food samples analyzed across the country. Based on this list, we estimated the dietary cancer risks for some of the selected pesticides. Finally, we searched for data about dietary cancer risks and carcinogenic mechanisms of each pesticide. We also provided a critical analysis concerning the pesticide scenario in Brazil, aiming to discuss the food contamination levels observed from a geographical, political, and public health perspective. Exposures to pesticides in Brazil violate a range of human rights when food and water for human consumption are contaminated.

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Section: In Vitro and In Vivo Datamentioning

confidence: 82%

Monitoring residues of pesticides in food in Brazil: A multiscale analysis of the main contaminants, dietary cancer risk estimative and mechanisms associated

Valentim

Fagundes²,

Ferreira³

et al. 2023

Front. Public Health

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“…In particular: Li, He, et al. ( 2022 ). Neonicotinoid insecticides promote breast cancer progression via G protein‐coupled estrogen receptor: In vivo, in vitro and in silico studies.…”

Section: Human Healthmentioning

confidence: 99%

“… In the study of Li, He, et al. ( 2022 ), the effect of acetamiprid on in situ growth of breast cancer cells in female mice and related mechanisms were studied. Ovariectomised and non‐ovariectomised mice were injected with 4T1‐luc cells (murine triple‐negative breast cancer cell line) and exposed daily by oral gavage for 3 weeks to acetamiprid (ovariectomised mice to 0, 1, 10 or 30 mg/kg bw per day; non‐ovariectomised mice to 0 or 10 mg/kg bw per day).…”

Section: Human Healthmentioning

confidence: 99%

“…For the Li, He, et al. ( 2022 ) and Mishani et al. ( 2022 ) studies, risk of bias was considered regarding blinding of research personnel to study group (Q4), possible attrition or exclusion from analysis (Q5), the exposure characterisation (Q6, key questions) and the outcome assessment (Q7, key question).…”

Section: Human Healthmentioning

confidence: 99%

“…For some of the endpoints of the Li, He, et al. ( 2022 ) study, also a risk of bias was considered regarding randomisation of the animals (Q1, key question).…”

Section: Human Healthmentioning

confidence: 99%

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Statement on the toxicological properties and maximum residue levels of acetamiprid and its metabolites

Hernandez‐Jerez,

Coja,

Paparella

et al. 2024

EFS2

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Acetamiprid is a pesticide active substance with insecticidal action whose approval was renewed by Commission Implementing Regulation (EU) 2018/113. In January 2022, the EFSA PPR Panel published a statement following a request from the European Commission to advise on human health or the environment based on new scientific evidence presented by France during the decision‐making phase. In July 2022, by means of a further mandate received from the European Commission, EFSA was requested to provide advice if new information and any other scientific evidence that has become available since the assessment conducted for the renewal in 2018 warrant re‐evaluation of (i) toxicological parameters used for the risk assessment of acetamiprid during the renewal process, including toxicological endpoints; (ii) the residue definition for acetamiprid in products of plant origin; and (iii) the safety of existing maximum residue levels (MRLs). Meanwhile, the applicant of acetamiprid in the EU submitted new toxicology studies regarding the toxicological profile of the metabolite IM‐2‐1. Furthermore, the European Commission was made aware that several recent publications in scientific literature were made available after the literature searches conducted by EFSA. As the new data could affect the advice that EFSA was expected to deliver through the 2022 mandate, EFSA was further requested to consider this information by means of a revised mandate received in September 2023. As regards re‐evaluation of point (i) in this statement, this was addressed by an EFSA Working Group integrating all the available evidence. The results of the weight of evidence indicated that there are major uncertainties in the body of evidence for the developmental neurotoxicity (DNT) properties of acetamiprid and further data are therefore needed to come to a more robust mechanistic understanding to enable appropriate hazard and risk assessment. In view of these uncertainties, the EFSA WG proposed to lower the acceptable daily intake (ADI) and acute reference dose (ARfD) from 0.025 to 0.005 mg/kg body weight (per day). A revised residue definition for risk assessment was proposed for leafy and fruit crops as sum of acetamiprid and N‐desmethyl‐acetamiprid (IM‐2‐1), expressed as acetamiprid. Regarding pulses/oilseeds, root crops and cereals, the new data received did not indicate a need to modify the existing residue definition for risk assessment, which therefore remains as parent acetamiprid. Regarding the residue definition for enforcement, the available data did not indicate a need to modify the existing definition because acetamiprid is still a sufficient marker of the residues in all crop groups. Considering the new health‐based guidance values derived in the present statement, a risk for consumer has been identified for 38 MRLs currently in place in the EU Regulation. Consequently, EFSA recommended to lower the existing MRLs for 38 commodities based on the assessment of fall‐back Good Agricultural Practices received within an ad...

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Neonicotinoids Toxicity to Humans and Rodents

Costas-Ferreira,

Faro

2024

Sustainable Landscape Planning and Natural Resources Management

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Neonicotinoid insecticides promote breast cancer progression via G protein-coupled estrogen receptor: In vivo, in vitro and in silico studies

Cited by 11 publications

References 60 publications

Monitoring residues of pesticides in food in Brazil: A multiscale analysis of the main contaminants, dietary cancer risk estimative and mechanisms associated

Monitoring residues of pesticides in food in Brazil: A multiscale analysis of the main contaminants, dietary cancer risk estimative and mechanisms associated

Statement on the toxicological properties and maximum residue levels of acetamiprid and its metabolites

Neonicotinoids Toxicity to Humans and Rodents

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