Neoplaether, a new cytotoxic and antifungal endophyte metabolite from<i>Neoplaconema napellum</i>IFB-E016

Wang, Feng W.; Ye, Yong H.; Chen, Jing R.; Wang, Xiao T.; Zhu, Haoyu; Song, Yong; Tan, Ren Xiang

doi:10.1111/j.1574-6968.2006.00358.x

Cited by 21 publications

(19 citation statements)

References 17 publications

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“…[8], Neoplaconema sp. [9], Penicillium sp. [10,11], Leathesia nana [12], Phyllanthus atropurpureus [13], Symphyocladia latiuscula [14], and so on.…”

Section: Introductionmentioning

confidence: 99%

Diphenyl ethers from Aspergillus sp. and their anti-Aβ42 aggregation activities

et al. 2014

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“…[8], Neoplaconema sp. [9], Penicillium sp. [10,11], Leathesia nana [12], Phyllanthus atropurpureus [13], Symphyocladia latiuscula [14], and so on.…”

Section: Introductionmentioning

confidence: 99%

Diphenyl ethers from Aspergillus sp. and their anti-Aβ42 aggregation activities

et al. 2014

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“…from Hopea hainanensis. The study on endophyte from H. hainanensis had not been reported previously except our group (Wang et al 2006). The compounds produced by our title fungus showed strong or moderate antifungal and cytotoxic activity, which confirmed the endophytic fungi were an important source of active natural products.…”

Section: Resultsmentioning

confidence: 95%

“…The aim of the present work was to systemically isolate and identify bioactive secondary metabolites from the title fungus. The literature to date showed no information on the chemistry and biology of any endophytes from Hopea hainanensis except our group (Wang et al 2006).…”

Section: Introductionmentioning

confidence: 98%

Bioactive metabolites from Penicillium sp., an endophytic fungus residing in Hopea hainanensis

Wang

Hou

Wang

et al. 2008

World J Microbiol Biotechnol

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The metabolites of endophytic fungus Penicillium sp. from the leaf of Hopea hainanensis were reported for the first time. By bioassay-guided fractionation, the EtOAc extract of a solid-matrix steady culture of this fungus afforded six compounds, which were identified through a combination of spectral and chemical methods (IR, MS, 1 H-and 13 C-NMR) to be monomethylsulochrin (1), rhizoctonic acid (2), asperfumoid (3), physcion (4), 7,8-dimethyl-iso-alloxazine (5) and 3,5-dichloro-p-anisic acid (6). Compounds 2, 3 and 6 were obtained from Penicillium sp. for the first time. All of the six isolates were subjected to in vitro bioactive assays including antifungal action against three human pathogenic fungi Candida albicans, Trichophyton rubrum and Aspergillus niger and cytotoxic activity against the human nasopharyngeal epidermoid tumor KB cell line and human liver cancer HepG2 cell line. As a result, compounds 2-4 and 6 inhibited the growth of C. albicans with MICs of 40.0, 20.0, 50.0 and 15.0 lg/ml, respectively and the compound 6 showed growth inhibition against A. niger with MICs of 40.0 lg/ml. In addition, compounds 1-3 and 6 exhibited cytotoxic activity against KB cell line with IC 50 value of 30.0, 20.0, 20.0, 5.0 lg/ ml, respectively and against HepG2 cell line with IC 50 value of 30.0, 25.0, 15.0, 10.0 lg/ml, respectively.

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“…They found that only cordyol C had moderate cytotoxic activity against both cell lines, with an IC 50 of 8.65μg/ml and 3.75 μg/ mL for BC and NCI-H187, respectively. Wang et al (2006) investigated the cytotoxic activity of a new diphenyl ether called Neoplaeter isolated from the cultivated fungus Neoplaconema napellum IFB-E016. Using the MTT assay, the authors observed a significant cytotoxic activity caused by Neoplaeter in the cell line KB (epidermoid nasopharyngeal cancer) with an IC 50 of 13 μg/mL.…”

Section: Discussionmentioning

confidence: 99%

Cellular responses induced in vitro by pestheic acid, a fungal metabolite, in a gastric adenocarcinoma cell line (PG100)

Sousa

Matos²,

Alcântara³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. There is a constant search for new cancer treatments that are less aggressive and economically affordable. In this context, natural products extracted from plants, fungi, and microorganisms are of great interest. Pestheic acid, or dihidromaldoxin, is a chlorinated diphenylic ether extracted from the phytopathogenic fungus Pestalotiopsis guepinii (Amphisphaeriaceae). We assessed the cytotoxic, cytostatic, and genotoxic effects of pestheic acid in a gastric adenocarcinoma cell line (PG100). A decrease in clonogenic survival was observed. Pestheic acid also induced significant increases in both micronucleus and nucleoplasmic bridge frequency. However, we did not observe changes in cell cycle kinetics or apoptosis induction. Reactive oxygen species induced by diphenylic ethers may explain the genotoxicity and mutagenicity of pestheic acid. The absence of repair checkpoints that we observed is probably due to the fact that the PG100 cell line lacks the TP53 gene, which is common in gastric cancers. Even though pestheic acid has had a clear cytotoxic effect, the minimal inhibitory concentration was high, which shows that pestheic acid is not an active anticancer compound under these conditions.

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Neoplaether, a new cytotoxic and antifungal endophyte metabolite fromNeoplaconema napellumIFB-E016

Cited by 21 publications

References 17 publications

Diphenyl ethers from Aspergillus sp. and their anti-Aβ42 aggregation activities

Diphenyl ethers from Aspergillus sp. and their anti-Aβ42 aggregation activities

Bioactive metabolites from Penicillium sp., an endophytic fungus residing in Hopea hainanensis

Cellular responses induced in vitro by pestheic acid, a fungal metabolite, in a gastric adenocarcinoma cell line (PG100)

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