Neoplastic Associations of Rheumatic Diseases and Rheumatic Manifestations of Cancer

Benedek, Thomas G.

doi:10.1016/s0749-0690(18)30752-3

Cited by 16 publications

(9 citation statements)

References 124 publications

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“…Carcinomatous polyarthritis has been reported with a variety of solid tumors including lung, gastric, colon, breast, ovarian, laryngeal, and pancreatic (Table 1) 3-5, [7][8][9][10][11] . The exact prevalence is unknown, but it is thought to be rare 4,12 . The age of onset generally reflects that of the associated malignancy.…”

Section: Discussionmentioning

confidence: 99%

Migratory Polyarthritis as a Paraneoplastic Syndrome

et al. 2008

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Carcinomatous polyarthritis (CP) is a rare paraneoplastic disorder that has been associated with a variety of solid tumors. It presents in a similar manner to other polyarticular disorders and often precedes detection of the underlying malignancy, making recognition critical. CP responds to the treatment of the neoplastic process. We present a patient who initially presented with asymmetric inflammatory polyarthritis who was later diagnosed with bronchogenic carcinoma. Following the case report we present our learning objectives, which include the differential diagnosis of inflammatory polyarthritis, diagnostic approach to CP, and features that distinguish it from other more common causes of polyarthritis. We conclude with a brief discussion of the pathophysiology and management of CP.KEY WORDS: carcinomatous polyarthritis; migratory arthritis; paraneoplastic syndrome.

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Section: Discussionmentioning

confidence: 99%

Migratory Polyarthritis as a Paraneoplastic Syndrome

et al. 2008

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“…Previous studies indicate a higher incidence of cancer in scleroderma patients (1)(2)(3)(4)(5)(6)(7). The strongest association has been with lung cancer (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). Isolated case reports suggest a higher incidence of bronchoalveolar type of lung carcinoma (15)(16)(17); however, none of the epidemiologic studies have confirmed that (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14).…”

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confidence: 99%

“…The strongest association has been with lung cancer (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). Isolated case reports suggest a higher incidence of bronchoalveolar type of lung carcinoma (15)(16)(17); however, none of the epidemiologic studies have confirmed that (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). Other types of cancers reportedly more common in scleroderma patients include breast cancer (1,5,6,10,(18)(19)(20)(21), nonmelanoma skin cancer (3), non-Hodgkin's lymphoma (1,22,23), esophageal cancer (24)(25)(26), and liver cancer (3).…”

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confidence: 99%

Risk of malignancy in scleroderma: A population‐based cohort study

Chatterjee¹,

Dombi²,

Severson³

et al. 2005

Arthritis & Rheumatism

116

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Objective. To determine the incidence of cancer in patients with scleroderma (systemic sclerosis) and to compare those rates with cancer rates in the local population.Methods. Cancer risk in scleroderma patients in the Detroit metropolitan area was assessed by linking patient identification codes of the Michigan Scleroderma Registry to the Metropolitan Detroit Cancer Surveillance System database. Patients were screened between the years 1973 and 2002, with additional followup to 2004. Standardized incidence ratios (SIRs) were calculated for selected malignancies (lung, liver, colon, breast, cervical, and prostate cancers, and nonHodgkin's lymphomas), with stratification by sex and race.Results. Of 934 patients in the Scleroderma Registry, 538 were included in the study based on tri-county residency (436 females and 102 males). Of these, 45 first malignancies were noted (37 females and 8 males). Lung cancer (10 cases) was found to be the most common cancer in scleroderma patients. However, its incidence was not significantly different from that in the general population of metropolitan Detroit (SIR 1.23). Other types of cancer were examined, and no significant differences were found as compared with the rates in the local population, with 1 exception: black females with scleroderma had significantly higher rates of liver cancer (SIR 45.8).Conclusion. Contrary to previous studies, this study did not find statistical evidence of an increased incidence of cancer in scleroderma patients, except for liver cancer. One possible reason is the high background rates of certain cancers in the metropolitan Detroit area. It may be necessary to consider local cancer rates when comparing different scleroderma cohorts.

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“…В последние годы при длительном проспективном наблюдении за большим количест вом больных установлено, что при РА достоверно повышается риск развития лимфогранулематоза и неходжкинских лимфом. На фоне ИБЛ, ассоци ированной с РА, повышается риск развития неходж кинских лимфом с поражением легких [25]. Относи тельно связи РА и рака легких единая точка зрения отсутствует: одни авторы обнаружили увеличение его частоты при длительно существующем РА, дру гие отрицают статистически достоверную зависи мость между этими заболеваниями.…”

Section: ревматоидные узелкиunclassified