Neoplastic disease after heart transplantation: single center experience

Rinaldi, Mauro; Pellegrini, Carlo; D’Armini, Andrea Maria; Aiello, Marco; Negri, M; Arbustini, Eloisa; Ippoliti, G; Viganò, Mario

doi:10.1016/s1010-7940(01)00674-1

Cited by 60 publications

(54 citation statements)

References 12 publications

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“…7 ). In our study it was not possible to calculate adjusted risk for different types of NMSC, as data in the external group do not specify the exact type of NMSC.The relatively low incidence of skin cancer in a cohort of HTRs was recorded by Rinaldiet al or Park et al in a single centre in Korea 8,9 . Unlike most studies reported, the authors found significantly higher incidence of lung cancer (39%) and non-Hodgkin lymphomas (20%).…”

Section: Discussionmentioning

confidence: 86%

Significantly higher incidence of skin cancer than other malignancies in patients after heart transplantation. A retrospective cohort study in the Czech Republic

Sečníková¹,

Göpfertová²,

Hošková³

et al. 2015

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Aims.To perform the first study in Czech Republic on heart transplant recipients (HTRs), compare the risks for different types of cancer and provide comprehensive analysis of skin cancer and other types of cancer morbidity from which we would be able to derive an evidence-based skin cancer surveillance program. Materials and Methods. A retrospective cohort study was performed to determine and compare standardized morbidity ratio (SMR) of different types of cancer developed after heart transplantation. We analysed data obtained from medical documentation of 603 HTRs transplanted between 1993 and 2010. Results. 191 incident cases of malignancy occurred in123 HTRs (20.4%). According to expectations, nonmelanoma skin cancer was the most frequent type of malignancy (119 cases) with SMR 7.6 (P < 0.001), followed by lung cancer with SMR 2.7 (P < 0.001). SMR for melanoma was 2.5, P = 0.129. Other types of cancer in HTRs (prostate and kidney cancer) were less frequent (SMR 2.06, P = 0.038 and SMR 2.03, P = 0.122). Conclusion. The risk of malignancy development is significantly higher for HTRs compared to the general population. Squamous cell carcinoma of the skin is the most frequent type of cancer followed by basal cell carcinoma. These findings emphasise the importance of regular skin cancer screening in HTRs.

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Section: Discussionmentioning

confidence: 86%

Significantly higher incidence of skin cancer than other malignancies in patients after heart transplantation. A retrospective cohort study in the Czech Republic

Sečníková¹,

Göpfertová²,

Hošková³

et al. 2015

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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“…The incidence of solid tumors is relatively low, and pancreatic cancer is particularly rare in HTx patients. 2) We have described here a case of pancreatic cancer that emerged 4 years and 8 months after HTx. The cancer was recognized by abnormalities in hepato-biliary enzymes due to biliary stricture and elevation of CA19-9.…”

Section: Discussionmentioning

confidence: 96%

“…1) Most malignancy emerges in skin or in the form of lymphoproliferative disorder, but pancreatic cancer has been infrequently reported in HTx patients. 2) To the best of our knowledge, there have been no reports on chemotherapy for pancreatic cancer in HTx patients.…”

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confidence: 99%

A Case of Pancreatic Cancer After Heart Transplantation

et al. 2012

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SummaryMalignancy is not uncommon with immunosuppressive therapy, but pancreatic cancer is infrequently complicated in recipients of heart transplantation. Here we report a transplant case diagnosed with pancreatic cancer 4 years and 8 months after the heart transplantation. We changed the immunosuppressive regimen after the malignancy was detected, and administered everolimus along with chemotherapy using S-1, an oral fluoropyrimidine prodrug. The patient lived for 8 months after the diagnosis, and received metallic stenting for the biliary and duodenal obstruction. Also, to the best of our knowledge, this is the first report about chemotherapy and endoscopic intervention for pancreatic cancer in a heart transplantation patient. (Int Heart J 2012; 53: 205-207)

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“…Indications for heart transplant Rinaldi and associates 13 and Goldstein and associates 14 have both presented considerable data regarding neoplastic diseases in cardiac transplant patients. In light of their studies, cardiomyopathy was identified as the single most important pathology leading to cardiac transplant.…”

Section: Introductionmentioning

confidence: 99%

“…13 Different types of drugs are used for immunosuppressive therapy in heart transplant patients, each with a different role during treatment. As reported by Rinaldi and associates, 13 the intensity of immunosuppression used to prevent and treat rejection is directly proportional to the adverse effects and posttransplant malignancies.…”

Section: Introductionmentioning

confidence: 99%

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Lateef

Basit²,

Abbasi³

et al. 2016

Exp Clin Transplant

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Along with graft vasculopathy, malignancies comprise a major complication after heart transplant, with a rate of occurrence of 39.1% in 10 years. Skin cancers and posttransplant lymphoproliferative disorder are more common in adults, whereas lymphoma is more often shown in children. A major cause of malignancies after heart transplant is the use of increased doses of prophylactics needed during immunosuppressive therapy. Data, however, are scarce regarding the association between a particular immunosuppressive drug and a posttransplant malignancy. Compared with the general population, recipients have a higher incidence of malignancies after heart transplant, with an early onset and more aggressive disease. Solid tumors known to occur in heart transplant recipients include lung cancer, bladder and prostate carcinoma, adenocarcinoma of the oral cavity, stomach cancer, and bowel cancer, although the incidence is rare. The risk factors for development of a malignancy after heart transplant are the same as for the nontransplant population.

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Neoplastic disease after heart transplantation: single center experience

Cited by 60 publications

References 12 publications

Significantly higher incidence of skin cancer than other malignancies in patients after heart transplantation. A retrospective cohort study in the Czech Republic

Significantly higher incidence of skin cancer than other malignancies in patients after heart transplantation. A retrospective cohort study in the Czech Republic

A Case of Pancreatic Cancer After Heart Transplantation

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