Neoplastic diseases of marine bivalves

Carballal, Marı́a J.; Barber, Bruce J.; Iglesias, David; Villalba, António

doi:10.1016/j.jip.2015.06.004

Cited by 97 publications

(128 citation statements)

References 186 publications

(466 reference statements)

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“…Advanced stages of the disease, with tissue infiltration by neoplastic hemocytes, are fatal in most affected bivalves (Barber 2004, Metzger et al 2015. Since first described in oysters from the eastern coast of the USA (Farley 1969), similar pathologies have been found globally in at least 23 bivalve species (Barber 2004, Carballal et al 2015. Although both prevalence and mortality vary by species and by locality, particularly susceptible populations include northwest Atlantic soft-shelled clam Mya arenaria (Barber 2004, Carballal et al 2015, northeast Atlantic common cockle Cerastoderma edule (Barber 2004, Carballal et al 2015, northeast Pacific bay mussel Mytilus trossulus (Barber 2004, Carballal et al 2015, and several populations of Baltic clam Macoma balthica (Christen sen et al 1974, Pekkarinen 1993, Thiriot-Quiévreux & Wolowicz 1996.…”

Section: Introductionmentioning

confidence: 94%

“…Disseminated, or hemic, neoplasias are leukemialike conditions that affect circulating hemocytes of a variety of bivalve mollusks (Carballal et al 2015). Advanced stages of the disease, with tissue infiltration by neoplastic hemocytes, are fatal in most affected bivalves (Barber 2004, Metzger et al 2015.…”

Section: Introductionmentioning

confidence: 99%

“…Whereas a variety of biotic and abiotic factors have been proposed (Barber 2004, Walker et al 2011, Carballal et al 2015, the etiology of disseminated neoplasia in M. arenaria is now well understood to in volve transmission of a clonal lineage of neoplastic cells from one clam to another (Metzger et al 2015, Mateo et al 2016. In moribund M. arenaria, neoplastic hemocytes exhibit high genomic copy number and high RNA ex-pression of the Steamer retrotransposon.…”

Section: Introductionmentioning

confidence: 99%

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Evidence of horizontal transmission of the cancer-associated Steamer retrotransposon among ecological cohort bivalve species

Paynter

Metzger²,

Sessa³

et al. 2017

Dis. Aquat. Org.

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Bivalve specimens from legacy frozen tissue collections, and others freshly obtained, were surveyed for the presence of the Steamer long terminal repeat (LTR)-retrotransposon associated with disseminated hemic neoplasia of the soft-shelled clam Mya areneria. Of 22 species investigated using primers for the pol region, only Atlantic M. arenaria, Atlantic and North Sea razor clams Ensis directus, and Baltic clams Macoma balthica from the North Sea were found to possess copies of Steamer in their genomes. Notably, close relatives like Mya truncata and Siliqua patula did not exhibit evidence of Steamer. Amplified Steamer sequences were uniformly identical in all M. areneria specimens, and were highly variable across specimens of E. directus. Variation in the latter included nucleotide polymorphisms among and within individuals as well as length variation in 2 specimens corresponding to the deletion of a predicted stable hairpin structure. Results implicate Atlantic razor clams as the proximal source for horizontal transmission of Steamer among ecologically similar yet markedly distantly related bivalves. The consequences of cross-species transmission of the Steamer retrotransposon are unknown, and the finding of Steamer in 3 bivalve species suggests that further spread is possible. KEY WORDS: Disseminated neoplasia · Hemic neoplasia · Retrotransposon · Steamer · Bivalvia · CancerResale or republication not permitted without written consent of the publisher Dis Aquat Org 124: [165][166][167][168] 2017 pression of the Steamer retrotransposon. Steamer is a long terminal repeat (LTR)-retrotrans poson in the Mag family of Ty3/Gypsy elements, complete with a single open reading frame encoding gag and pol genes. Retrotransposons are present in genomic DNA and replicate through reverse transcription of an mRNA transcript into DNA, followed by integration into a new location within the genomic DNA of a cell. As they are notably lacking a retroviral env gene, they are not expected to be able to transfer from cell to cell, as retroviruses do. Similar retrotransposons have been identified in the genomes of 3 other bivalve species known to have transmissible neoplasias, one of which seems to cross the species boundary (Metzger et al. 2016).To date, the Steamer retrotransposon itself is un ique to M. arenaria. Here we examined legacy bio diversity collections and freshly acquired bivalve tissues for the presence of a Steamer signature in their genomes in a manner that might (1) better elucidate whether disseminated neoplasias are ecologically or phylogenetically determined and (2) shed light on the potential for horizontal spread and genomic modification by Steamerlike retrotransposons in the marine environment. MATERIALS AND METHODSBivalve tissue samples were obtained from the American Museum of Natural History's Ambrose Monell Cryo Collection (AMCC), and included 22 species from the North Atlantic (see Table S1 in the Supplement at www. int-res. com/ articles/ suppl/ d124 p165 _ supp. pdf). Fresh specimens of steam...

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Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evidence of horizontal transmission of the cancer-associated Steamer retrotransposon among ecological cohort bivalve species

Paynter

Metzger²,

Sessa³

et al. 2017

Dis. Aquat. Org.

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“…Many studies have emerged on systemic neoplasia, and these have demonstrated interesting links to haematopoiesis. The specific characteristics of systemic neoplasia in bivalves have been reviewed in detail by Carballal et al (2015) [102]. Briefly, there is an increase in the infiltration of atypical mitotic cells in the connective tissue and in the haemolymph sinuses and tissues of the circulatory system.…”

Section: Bivalve Haematopoiesis and Haemocyte Functionmentioning

confidence: 99%

Haematopoiesis in molluscs: A review of haemocyte development and function in gastropods, cephalopods and bivalves

Pila

Sullivan

et al. 2016

Developmental & Comparative Immunology

115

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Haematopoiesis is a process that is responsible for generating sufficient numbers of blood cells in the circulation and in tissues. It is central to maintenance of homeostasis within an animal, and is critical for defense against infection. While haematopoiesis is common to all animals possessing a circulatory system, the specific mechanisms and ultimate products of haematopoietic events vary greatly. Our understanding of this process in non-vertebrate organisms is primarily derived from those species that serve as developmental and immunological models, with sparse investigations having been carried out in other organisms spanning the metazoa. As research into the regulation of immune and blood cell development advances, we have begun to gain insight into haematopoietic events in a wider array of animals, including the molluscs. What began in the early 1900’s as observational studies on the morphological characteristics of circulating immune cells has now advanced to mechanistic investigations of the cytokines, growth factors, receptors, signalling pathways, and patterns of gene expression that regulate molluscan haemocyte development. Emerging is a picture of an incredible diversity of developmental processes and outcomes that parallels the biological diversity observed within the different classes of the phylum Mollusca. However, our understanding of haematopoiesis in molluscs stems primarily from the three most-studied classes, the Gastropoda, Cephalopoda and Bivalvia. While these represent perhaps the molluscs of greatest economic and medical importance, the fact that our information is limited to only 3 of the 9 extant classes in the phylum highlights the need for further investigation in this area. In this review, we summarize the existing literature that defines haematopoiesis and its products in gastropods, cephalopods and bivalves.

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“…Disseminated neoplasia is a cancerous disease reported from multiple bivalve mollusc species (Carballal et al 2015). High mortality linked with neoplasia has been reported from Galician common cockle C. edule beds (Carballal et al 2001, Villalba et al 2001, Ordás & Figueras 2005, Díaz et al 2016; this disease was also reported in cockles C. edule from Ireland (Twomey & Mulcahy 1988) and France (Poder & Auffret 1986, Le Grand et al 2010.…”

Section: Discussionmentioning

confidence: 99%

Parasites, pathological conditions and resistance to Marteilia cochillia in lagoon cockle Cerastoderma glaucum from Galicia (NW Spain)

Carballal¹,

Iglesias²,

Darriba³

et al. 2016

Dis. Aquat. Org.

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A histopathological survey revealed parasites and pathological conditions affecting lagoon cockles Cerastoderma glaucum along the Galician coast; serious pathological threats were not detected because the potentially pathogenic conditions (infections with a Marteilia-like parasite and bucephalid sporocysts, disseminated neoplasia and a condition involving large foci of heavy haemocytic reaction) were rare, while more prevalent parasites had negligible or limited pathogeny. Considering that C. edule and C. glaucum are sympatric in some Galician rias, it is remarkable that C. glaucum was not seriously affected by Marteilia cochillia while C. edule suffered an intense outbreak of this parasite associated with massive mortality. Comparison of the digestive gland between cockle species showed co-occurrence of digestive tubules in different phases, with abundant disintegrated tubules, in the case of C. glaucum, while C. edule showed synchronicity and absence of fully disintegrated tubules; these differences could in fluence their susceptibility to M. cochillia because the main location of this parasite in common cockles is the epithelia of the digestive gland. Moreover, the observation of histological sections through the digestive gland easily allows differentiating the 2 cockle species.

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Neoplastic diseases of marine bivalves

Cited by 97 publications

References 186 publications

Evidence of horizontal transmission of the cancer-associated Steamer retrotransposon among ecological cohort bivalve species

Evidence of horizontal transmission of the cancer-associated Steamer retrotransposon among ecological cohort bivalve species

Haematopoiesis in molluscs: A review of haemocyte development and function in gastropods, cephalopods and bivalves

Parasites, pathological conditions and resistance to Marteilia cochillia in lagoon cockle Cerastoderma glaucum from Galicia (NW Spain)

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