Neoplastic invasion of the pulmonary veins and left auricle

McDonald, Stuart; Heather, J Cordell

doi:10.1002/path.1700480307

Cited by 45 publications

(4 citation statements)

References 11 publications

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“…Comment R. E. B. Hudson (1966, personal communication) was good enough to examine colour slides of the specimen and remarked on the one hand on the rarity of this condition and on the other on the similarity between this and sarcoma of the atrium and atrial myxoma as far as the macroscopical appearances were concerned. McDonald and Heather (1939), reviewing the published reports on neoplastic invasion of pulmonary veins and left atrium, quoted a case reported by Mead (1932) which was very similar to our own. In this case a large area of the contiguous portions of the upper and middle lobes of the right lung was composed of carcinomatous tissue.…”

Section: Case Reportsupporting

confidence: 86%

Unusual Secondary Tumour of Heart

Rogen

Moffat²

1967

Heart

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Secondary tumours of the heart are not uncommon. Hudson (1965) gives a full bibliography. The degree and site of involvement, however, are variable. They may occur in widely disseminated neoplasms such as melanomas and lymphoblastomas, or be the result of tumours with a tendency to grow along veins. The latter may extend into the atrium; this appears to be less rare on the right than on the left side of the heart. Willis (1953) quoted Herzog (1917) who described a teratoma of testis which passed through the inferior vena cava to the right atrium and ventricle, and he himself reports that some cases of renal carcinoma and of chondrosarcoma have been described, extending through the inferior vena cava into the right side of the heart and even into the pulmonary arteries. Willis noted, however, that the pulmonary veins were invaded by tumour only rarely. In view of the rarity of invasion of the pulmonary vein by tumour tissue the surprising findings at necropsy in our case prompted us to make this brief report, particularly since in retrospect they probably explain the sudden onset of heart failure not understood by us at the time of its occurrence. Case ReportA 38-year-old man was admitted to Stobhill Hospital, Glasgow, on April 21, 1965 with polyarthritis. For some four months he had had recurring pain in the right shoulder and elbow joints and both ankle joints.Over this period he had experienced frequent severe sweats. There had been no significant change in weight. He had a cough which he attributed to a heavy cigarette consumption of up to 40 a day, but he had not noticed anything unusual about the character of sputum.There was striking finger-clubbing and some thickening of the right wrist. There was wasting of the right deltoid muscle. Clinical signs of consolidation were noted in the right upper lobe. The chest x-ray film was unusual; it showed two large homogeneous opacities in the upper'part of the right lung field (Fig. 1). The lateral view showed that one of them was in the apical segment and the other in the anterior segment of the right upper lobe. The right lobe of the diaphragm was raised.The diagnosis was made of intrapulmonary tumour of doubtful aetiology, pulmonary osteoarthropathy, and ? carcinomatous neuropathy. He was anemic (Hb-8-9 g./100 ml.). His sedimentation rate was 133 mm. in one hour, and his temperature was raised. His main complaint in the first few days after admission was of pain in the shoulder and wrist joints. The chest x-ray appearances prompted a search for a primary focus outside the lungs but none was found in breast, thyroid, kidneys, or alimentary tract. Bronchoscopy was not carried out, because the surgeon, like ourselves, was of the opinion that the lung involvement was almost certainly secondary, and because the patient was extremely distressed and dyspnoeic when seen by him four days after admission. He had become dramatically more dyspnaeic in these four days, and signs of rightsided heart failure had developed. This we were unable to explain on clinical grounds. H...

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Section: Case Reportsupporting

confidence: 86%

Unusual Secondary Tumour of Heart

Rogen

Moffat²

1967

Heart

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“…The frequent occurrence of distant haematogenous metastases after surgical excision is a common experience, and this can occur only when malignant infiltration of the pulmonary veins has taken place. Since Siegert (1893) described macroscopic and microscopic evidence of malignant involvement of the pulmonary veins, Wolf (1895), Weller (1929), Simpson (1929), McDonald and Heather (1939), Aylwin (1951), and Hinson and Nohl (1960) all noted frequent involvement of the pulmonary veins in primary bronchial carcinomas. Galluzi and Payne (1955) and Willis (1966) maintained that though gross invasion of the veins is common, pulmonary arteries, although very frequently surrounded by grow;th, are rarely found to be invaded at necropsy.…”

Section: Methodsmentioning

confidence: 99%

Primary pulmonary cavitating carcinomas

1973

Thorax

146

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A primary lung cancer can produce a cavity in three ways. The first is 'cavitary necrosis' due to breakdown of the growth itself. The second is 'stenotic abscess' due to infection and breakdown of the lung parenchyma distal to bronchial obstruction caused by the growth. The third type is 'spill-over abscess'.In The single most important and noteworthy feature in the present series was that oat-cell carcinoma hardly ever undergoes necrosis. Out of a total of 95 cases observed, only three showed necrosis, and this was minimal and characteristically devoid of cavitation. In oat-cell carcinoma vascular invasion and tumour plugging was not observed, though all showed rapid growth and most of them blocked the lobar bronchi completely. In the light of the present study, the main factors responsible for tumour necrosis were found to be gradual bronchial obstruction and associated vascular involvement, though in many cases an inherent propensity of the tumour played a major role.A cavity or an abscess in the lung is defined as an abnormal hollow space within the lung parenchyma. Cavitation is one of the commonest phenomena in the lung. The

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“…Cystic pulmonary malformation can serve as a substrate for the development of primary RMS, pleuropulmonary b l a s t o m a , m y x o s a r c o m a , r e t i c u l o s a r c o m a , hemangiopericytoma, bronchogenic carcinoma, and mesenchymoma. [6] The commonest primary lung tumors under the age of 15 years are bronchial adenoma (carcinoid, mucoepidermoid carcinoma, and adenoid cystic carcinoma), bronchogenic carcinoma (mostly as adenocarcinoma or undifferentiated small cell carcinoma), and plasma cell granuloma. In contrast, leiomyosarcoma, fibrosarcoma, bronchial papillomatosis, pulmonary RMS, and pulmonary blastoma are rare.…”

Section: Discussionmentioning

confidence: 99%

Primary pulmonary rhabdomyosarcoma in children: Report of three cases with review of literature

Lokesh

Premalata

Kumari

2013

Indian Journal of Medical and Paediatric Oncology

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Primary pulmonary rhabdomyosarcoma in children is rare. Three children aged three, nine and three years were evaluated for abnormal shadows on radiological examination with pneumothorax in two cases. Resection and histopathological examination revealed embryonal rhabdomyosarcoma in all and cystic malformation in first case. All the three children were treated with surgery and first two received adjuvant chemotherapy. The disease free duration was 160 months, 19 months and seven months respectively. The literature on primary pulmonary rhabdomyosarcoma in children was reviewed.

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Neoplastic invasion of the pulmonary veins and left auricle

Abstract: INVASION of the left auricle by malignant tumours via the pulmonary veins constitutes a pathological entity which has received relatively little attention in the literature.

Cited by 45 publications

References 11 publications

Unusual Secondary Tumour of Heart

Unusual Secondary Tumour of Heart

Primary pulmonary cavitating carcinomas

Primary pulmonary rhabdomyosarcoma in children: Report of three cases with review of literature

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