Neoplastic involvement of granulocytic lineage, not granulocytic‐monocytic, monocytic, or erythrocytic lineage, in a patient with chronic neutrophilic leukemia case report

Abstract

Chronic neutrophilic leukemia (CNL) is a very rare myeloproliferative disorder. To determine the neoplastic origin of CNL, morphological and cytogenetical studies were made of colonies derived from hematopoietic progenitors of a patient with CNL. The patient's hematopoietic progenitors spontaneously formed colonies consisting of mature granulocytes, and cytogenetical study of the colonies indicated chromosome abnormalities identical to those in the patient's bone marrow cells. Analysis of colonies consisting of granulocytes and macrophages, macrophages, or erythrocytes disclosed a normal karyotype. These results demonstrated that the neoplastic process in this patient with CNL originated in hematopoietic progenitors capable of differentiating only into granulocytes, and not granulocytes and monocytes, monocytes, or erythrocytes. Am. J. Hematol. 57:221-224, 1998.

Chronic Neutrophilic Leukaemia: A Distinct Clinical Entity?

“…Rare transformations to myeloid metaplasia (Zittoun et al , 1994), the frequent development of acute leukaemia (Katsuki et al , 2000), and the fact that a number of patients with polycythaemia have been reported to transform to CNL (Shirakura et al , 1979; Lugassy & Farhi, 1989; Iurlo et al , 1990; Foa et al , 1991; Fujisawa et al , 1992; Harada et al , 1993; Higuchi et al , 1999) suggests, at least in some cases, that the abnormality may be at the haematopoietic stem cell level. Yanagisawa et al (1998), however, reported a patient whose haematopoietic progenitors spontaneously formed colonies consisting of large numbers of mature granulocytes that possessed the same cytogenetic abnormality as that found in the bone marrow. In contrast, the karyotype of the granulocytic‐macrophage and macrophage colony‐forming units, as well as the erythroid burst‐forming unit, were normal.…”

Familial occurrence of chronic neutrophilic leukaemia

“…This patient, the proband, has been reported previously in another context (Yanagisawa et al , 1998). In September 1994 he was referred to us because of massive hepatosplenomegaly.…”

Familial occurrence of chronic neutrophilic leukaemia

“…Case 1 (father) This patient, the proband, has been reported previously in another context (Yanagisawa et al, 1998). In September 1994 he was referred to us because of massive hepatosplenomegaly.…”