Neoplastic Meningitis

Horn, Alixis Van; Chamberlain, Marc C.

doi:10.1016/j.suponc.2011.06.002

Cited by 24 publications

(14 citation statements)

References 34 publications

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“…Leptomeningeal metastasis (LM) is a deleterious complication of breast cancer leading to death within less than 4–6 months following the diagnosis [1–4]. It touches between 2 and 5 % of patients with metastatic breast cancer, usually later in the course of their disease.…”

Section: Introductionmentioning

confidence: 99%

“…It touches between 2 and 5 % of patients with metastatic breast cancer, usually later in the course of their disease. LM presents a challenge for an oncologist because of the difficulty in determining the diagnosis and lack of optimal therapy [1, 2, 4]. Early diagnosis of LM is important in order to prevent the development of severe neurological deficits that cannot be reversed with treatment.…”

Section: Introductionmentioning

confidence: 99%

“…Due to the fact that LM is becoming an increasingly common complication of breast cancer [2, 4] it is important to know which histological and biological type of newly diagnosed breast cancer has the propensity to metastasize to the leptomeninges and what type of treatment of LM is mostly effective.…”

Section: Introductionmentioning

confidence: 99%

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Breast cancer leptomeningeal metastasis: propensity of breast cancer subtypes for leptomeninges and the analysis of factors influencing survival

2013

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The aim of the study was to define biological subtypes of breast cancer that have the propensity to metastasize to the leptomeninges and to assess factors influencing survival from detection of leptomeningeal metastatis (LM). One hundred and eighteen consecutive breast cancer patients with LM were treated in one institution, between the years 1999 and 2009; 40.5 % of patients had triple-negative subtype, 37.5 % had luminal A subtype and 22 % had HER2-positive subtypes (luminal B and HER2). Of patients with LM, 35 % had lobular cancer. Median survival from the detection of LM was 18 weeks, and 1-year survival was 16 %. Cox multivariate analysis revealed that performance status and systemic treatment statistically significantly influenced survival of patients with LM. Triple-negative biological subtype and lobular histological type of breast cancer had the propensity to metastasize to the leptomeninges. Performance status and systemic treatment ordered after detection of LM statistically significantly influenced survival.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Breast cancer leptomeningeal metastasis: propensity of breast cancer subtypes for leptomeninges and the analysis of factors influencing survival

2013

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“…This condition commonly results in tumor growth within the IAC as is shown in our cohort (13/18 TBs) and is often preceded by progressive SNHL prior to the motor deficits, usually bilaterally (9/13 in our cohort). The incidence of neoplastic meningitis (NM) is rising, but this condition has received little attention as a potential etiology for PFnP partly due to the terminal condition of these patients. Recent therapeutic improvements may improve the long‐term survival of these patients and may change this trend.…”

Section: Discussionmentioning

confidence: 99%

Histological characteristics of intra‐temporal facial nerve paralysis in temporal bone malignancies

et al. 2019

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Objective: To describe the histopathologic findings and clinical presentation of intra-temporal facial nerve invasion in primary and metastatic malignancies of the human temporal bone (TB).Materials and Methods: Retrospective analysis of all medical records of patients diagnosed with peripheral facial nerve palsy (PFnP) of a malignant origin was performed. Temporal bones underwent standard processing for histologic examination. Hematoxylin and eosin (H&E)-stained slides were examined by light microscopy. The histologic findings were compared to premortem clinical data.Results: Eighteen TBs were identified in 16 patients. The male to female ratio was 9:7. The median (range) age of death was 56.5 years (27 months to 75 years). The median time interval from facial nerve injury to death was 5.5 months. There were 11 carcinomas and seven sarcomas identified. Primary TB malignancies were identified in seven TBs (39%), and the rest (11 TBs, 61%) were of metastatic origin. Complete facial nerve paralysis (House-Brackmann [HB] grade VI), was the most common clinical presentation affecting nine patients (10 TBs, 56%). Neural involvement was multifocal in nature (16 of 18 TBs, 89%). The most commonly involved cranial nerve (CN) VII segment was the meatal segment (13 TBs, 72%), followed by the labyrinthine, tympanic, and vertical segments (nine, eight, and six TBs, respectively).Conclusion: PFnP can be the result of local, regional, or distant malignancy, and is associated with poor survival. The facial nerve can serve as a route of tumor progression intracranially. Whereas every segment of CNV II can be violated by tumors, not all PFnP are related to direct tumor invasion.

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“…[5,6] As a gradual increase of incidence and a high mortality have been observed over time, early diagnosis is crucial. Due to its diverse clinical manifestations, it is difficult to make a diagnosis only with imaging examinations and CSF cytology is necessary to find abnormal cells.…”

Section: Discussionmentioning

confidence: 99%

Meningeal carcinomatosis: a retrospective analysis of seventy-seven cases

Chu¹,

Lang²,

Sun³

et al. 2017

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Aim: Meningeal carcinomatosis is a special type of malignant tumor characterized by short survival and poor prognosis. In the present study, the authors aim to analyze the clinical, laboratory data and prognosis of meningeal carcinomatosis patients. Methods: The authors enrolled 77 cases of meningeal carcinomatosis from 2003 to 2013 in the First Hospital of Jilin University. The clinical data including age, gender, symptoms at onset, clinical manifestations, primary tumors and the laboratory data including cerebrospinal fluid (CSF), tumor markers as well as the imaging data were analyzed. The interval between the onset of primary tumor and the onset of central nervous symptoms, treatments and survival time were also analyzed. Results: The onset of meningeal carcinomatosis was usually acute (46.2%) or subacute (39.0%). The most frequent symptom at onset was intracranial hypertension (70.1%). Symptoms such as headache, vomit and high lumbar puncture intracranial pressure was observed in 56% of cases during the course of the disease. CSF abnormalities such as higher protein concentration (73.4%), more CSF pleocitosis (57.1%) and lower glucose levels (48.4%) were found in 95.3% of meningeal carcinomatosis patients. Non-contrast enhanced cerebral magnetic resonance imaging (MRI) showed that 13.2% patients had abnormal meningeal changes while in the enhancement scan 35.3% patients showed changes. The serum tumor markers increased in 84% of the patients. There were no differences regarding the mean survival between patients who received intrathecal chemotherapy and those who received brain radiotherapy or supportive treatment. Conclusion: The most common clinical manifestation of meningeal carcinomatosis is intracranial hypertension. The most common primary tumor is lung cancer, followed by gastric cancer and breast cancer. The linear enhancement of meningeal on the MRI scan is of great importance for the diagnosis of meningeal carcinomatosis. Key words:Meningeal carcinomatosis, cerebrospinal fluid, magnetic resonance imaging, therapy ABSTRACTArticle history:

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Neoplastic Meningitis

Cited by 24 publications

References 34 publications

Breast cancer leptomeningeal metastasis: propensity of breast cancer subtypes for leptomeninges and the analysis of factors influencing survival

Breast cancer leptomeningeal metastasis: propensity of breast cancer subtypes for leptomeninges and the analysis of factors influencing survival

Histological characteristics of intra‐temporal facial nerve paralysis in temporal bone malignancies

Meningeal carcinomatosis: a retrospective analysis of seventy-seven cases

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