Neoplastic wounds and degenerescence

Meaume, Sylvie; Fromantin, Isabelle; Téot, Luc

doi:10.1016/j.jtv.2013.07.001

Cited by 26 publications

(21 citation statements)

References 35 publications

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“…33,34 Likewise, chronic inflammation from nonhealing wounds can lead to malignant transformation with the development of epithelial carcinomas or other malignancies such as lymphoma. 33,35 Although sarcoma and, to a lesser extent, squamous cell carcinoma are most frequently encountered in anatomic locations exposed to radiation, reports also exist of radiation-induced lymphoma and adenocarcinoma, which was the most frequently observed SMN in the current study. 36 Physicians caring for cancer survivors should have a low threshold to perform a focused perianal evaluation, including a digital rectal examination for anorectal complaints.…”

Section: Discussionmentioning

confidence: 55%

Late‐onset anorectal disease and psychosocial impact in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study

Madenci

Dieffenbach

Liu

et al. 2019

Cancer

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BACKGROUND:The prevalence and associated psychosocial morbidity of late-onset anorectal disease after surgery and radiotherapy for the treatment of childhood cancer are not known. METHODS: A total of 25,530 survivors diagnosed between 1970 and 1999 (median age at cancer diagnosis, 6.1 years; age at survey, 30.2 years) and 5036 siblings were evaluated for late-onset anorectal disease, which was defined as a self-reported fistula-in-ano, self-reported anorectal stricture, or pathology-or medical record-confirmed anorectal subsequent malignant neoplasm (SMN) 5 or more years after the primary cancer diagnosis. Piecewise exponential models compared the survivors and siblings and examined associations between cancer treatments and late-onset anorectal disease. Multiple logistic regression with generalized estimating equations was used to evaluate associations between late-onset anorectal disease and emotional distress, as defined by the Brief Symptom Inventory 18 (BSI-18), and health-related quality of life, as defined by the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36). RESULTS: By 45 years after the diagnosis, 394 survivors (fistula, n = 291; stricture, n = 116; anorectal SMN, n = 26) and 84 siblings (fistula, n = 73; stricture, n = 23; anorectal neoplasm, n = 1) had developed late-onset anorectal disease (adjusted rate ratio [RR] for survivors vs siblings, 1.2; 95% confidence interval [CI], 1.0-1.5). Among survivors, pelvic radiotherapy with ≥30 Gy within 5 years of the cancer diagnosis was associated with late-onset anorectal disease (adjusted RR for 30-49.9 Gy vs none, 1.6; 95% CI, 1.1-2.3; adjusted RR for ≥50 Gy vs none, 5.4; 95% CI, 3.1-9.2). Late-onset anorectal disease was associated with psychosocial impairment in all BSI-18 and SF-36 domains. CONCLUSIONS: Late-onset anorectal disease was more common among childhood cancer survivors who received higher doses of pelvic radiotherapy and was associated with substantial psychosocial morbidity. Cancer 2019;125:3873-3881.

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Section: Discussionmentioning

confidence: 55%

Late‐onset anorectal disease and psychosocial impact in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study

Madenci

Dieffenbach

Liu

et al. 2019

Cancer

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“…In patients with skin cancer, the local and regional lymph node status should be assessed first. In melanomas, sarcomas and ulcerated metastases of other cancers, the presence of multiple metastases and spreading features of the disease (computed tomography, magnetic resonance imaging or PET) should be excluded in the first place [5]. The most important objective of surgical treatment of skin giant neoplastic ulcers is radical excision of the tumor.…”

Section: Discussionmentioning

confidence: 99%

“…Among metastatic neoplastic ulcers, the most frequently described are metastases of breast cancer and reproductive organ cancer [1][2][3]. In the medical literature, neoplastic ulcers are called skin giant neoplastic ulcers, large cancer ulcers, as well as major cancer ulcers [4][5][6][7]. For the purpose of this study, the definition of "giant neoplastic ulcers" was adopted, understood as chronic defects in body integuments (of neoplastic origin) that require: • extensive local plastic surgery with the help of skin and fasciocutaneous flaps or • the use of skin grafts of split thickness to cover the resulting loss of body integuments, or • multiorgan or block resections.…”

Section: Introductionmentioning

confidence: 99%

Skin giant neoplastic ulcers – treatment options and clinical challenges

Girnyi¹,

Serkies²,

Jaworski³

et al. 2019

Nowotwory. Journal of Oncology

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Introduction . Skin giant neoplastic ulcers are a very serious diagnostic and therapeutic problem. The objective of this work was to present the experiences and strategies of our center concerning the treatment of this type of neoplastic ulcers. Material and methods . In this paper we present and analyze 15 cases of patients treated for giant ulcers. This represented 0.4% of all patients treated surgically for skin cancer in our center (n = 3983). Ulcers in this group of patients were located within the head (n = 6), chest (n = 4), abdomen (n = 2), male genitals (n = 1) and lower limbs (n = 2). Results . Our observations indicate that the treatment of giant skin neoplastic ulcers (although they are relatively rare) is a major clinical challenge and requires individualized multidirectional diagnostic and therapeutic methods.

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“…Embora seja comum entre os clínicos o conceito de que a ferida (FNM) é o reflexo da progressão da doença, fato também reconhecido na literatura internacional 1,[43][44] poucos, porém, sucessivos estudos vêm mostrando que a FNM não está associada à diminuição de sobrevida 2,[45][46][47][48] . No entanto, os estudos não são homogêneos em suas formas de seleção e avaliação clínica de pacientes e histologia dos tumores.…”

Section: O Câncer De Mamaunclassified

“…O exsudato ocorre pelo processo de lise das membranas celulares e apoptose, alteração da homeostase da linfa, processo inflamatório tecidual, hiperpermeabilidade de microvascularização do tumor ao fribrinogênio e coloides do plasma e secreção de fator de permeabilidade celular, sendo resultante do processo adicional de infecção e degeneração tecidual, por meio de liberação bacteriana de proteases que decompõem o tecido necrosado 44,[65][66] . Proliferação celular ativa também estimula a produção de exsudato que, por sua vez, aumenta o processo inflamatório, fazendo com que a FNM fique circunscrita aos eventos de inflamação e destruição tissular, assim como qualquer outra lesão do tipo crônica 64 .…”

Section: Sinais E Sintomasunclassified

Eficácia da celulose oxidada regenerada no controle do sangramento de feridas neoplásicas malignas decorrentes de câncer de mama: ensaio clínico randomizado

Firmino¹

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Neoplastic wounds and degenerescence

Cited by 26 publications

References 35 publications

Late‐onset anorectal disease and psychosocial impact in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study

Late‐onset anorectal disease and psychosocial impact in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study

Skin giant neoplastic ulcers – treatment options and clinical challenges

Eficácia da celulose oxidada regenerada no controle do sangramento de feridas neoplásicas malignas decorrentes de câncer de mama: ensaio clínico randomizado

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