Neopterin - a potential diagnostic and prognostic marker in infection diseases

Dudina, K.R.; M, Kutateladze; Знойко, О О; Бокова, Н. О.; Shutko, S A; Козина, А Н; Огарев, В. В.; Yushchuk, N D

doi:10.17816/kmj2009

Cited by 4 publications

(1 citation statement)

References 35 publications

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“…Neopterin is a biologically stable metabolite, which gives an advantage of its detection in assessing the activity of the immune response (5) . An association between CRP and ESR levels as well as neopterin concentrations 2806 has been shown already earlier in patients with many diseases such as cardiovascular disease and malignancies as well as in patients with RA (6) .…”

Section: Introductionmentioning

confidence: 99%

Serum Neopterin Level in Children with Juvenile Idiopathic Arthritis

Dower

Abdelhameed²,

Maksoud³

et al. 2018

Egyptian Journal of Hospital Medicine

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Background: Juvenile idiopathic arthritis (JIA) is generally considered a clinical syndrome involving several disease subsets, with a number of inflammatory flows, leading to an eventual common pathway in which persistent synovial inflammation and associated damage to articular cartilage and underlying bone are present. Neoptrin is a reliable marker in the assessment of the rate of IFN-γ production. Levels of neoptrin increase in direct proportion with the level of interferon. Measurement of neopterin level is useful because of its relative stability also it is a prognostic indicator for cell-mediated immunity. Aims: This study aims to assess serum level of neopterin in patients with Juvenile Idiopathic Arthritis (JIA) in relation to the disease activity, severity and response to conventional and biological therapy. Methodology: The study was conducted on 30 patients (Group A) previously diagnosed as SoJIA, they were divided into two subgroups according to their therapy into Group AI on biological therapy (15 patients) and Group AII on conventional therapy (15 patients). These in addition to 20 healthy controls (Group B). Results: Basic clinical evaluation and laboratory investigations were done. We found that JIA patients had significantly higher levels of serum neopterin than healthy controls. We also found a highly significant difference between neopterin levels in the activity and remission states among all patients (Group AI and Group AII). Conclusion: We concluded that serum neopterin is a useful marker for cellular immune activation and also indicative of the activity of JIA. Our findings are supported by positive correlations between serum neopterin levels and other markers of activity as TLC, PLT counts, ESR, and CRP. We also concluded that serum neopterin is a sensitive and accurate predictor of disease activity where sensitivity of that test was 93.3% and accuracy was 72.5%. Recommendations: Investigating the serum neopterin measurement in other autoimmune collagen diseases. Assessment the influence of biological therapy on neopterin levels in relation to disease progression.

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Section: Introductionmentioning

confidence: 99%

Serum Neopterin Level in Children with Juvenile Idiopathic Arthritis

Dower

Abdelhameed²,

Maksoud³

et al. 2018

Egyptian Journal of Hospital Medicine

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Lipopolysaccharide-binding protein, neopterin and interferon-gamma as indices of inflammation activity in patients with acute brucellosis

Sannikova

Mahinja

Ковалевич

et al. 2018

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Brucellosis is characterized by nonspecific clinical manifestations, the possibility of subclinical flow, the development of relapses and chronic course. Currently, there are nolaboratory criteria to assess the activity of inflammation in brucellosis, the effectiveness of the therapy, predict the outcome of the disease and the risks of recurrence. Available in clinical practice, laboratory tests to assess inflammation, in particular, erythrocyte sedimentation rate, C-reactive protein, leukocyte level, with brucellosis infection are almost not informative. An important role in the development of the cellular immune response against brucella is played by interferon-γ, lipopolysaccharide-binding protein and neopterin. The aim of the study was to determine the level of lipopolysaccharide-binding protein, neopterin and interferon-γ,in the serum of patients with acute form of brucellosis beforeand after antibacterial treatment. When studying the blood of patients with acute brucellosis before and after therapy, the indices of neopterin, lipopolysaccharide-binding protein and interferon-γ were significantly higher than normalvalues. The obtained results testify to the persisting active inflammation and the formation of a chronic brucellosis. Determination of the level of lipopolysaccharide-binding protein, neopterin and interferon-γ in the blood of patients withbrucellosis can be used as markers of inflammation and in monitoring the effectiveness of antibacterial therapy.

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Dynamics of the detection rate for infectious diseases during blood collection from donors in Russia and factors affecting it

Grozin

Devlikamov

2020

Vrač Skoroj Pomoŝi (Emergency Doctor)

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A study on the detection of infectious diseases during blood donation in Russia was carried out with the aim of explaining the actual problems of blood collection, its safety and benefits, statistical data and implementation of research systems. The authors reviewed the literature from modern domestic and foreign sources. Characteristic of the detection rate for infectious diseases is presented on the basis of their analysis. Causes of such diseases during blood transfusion are determined, preventive measures, methods of working with donors are described.

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Neopterin - a potential diagnostic and prognostic marker in infection diseases

Cited by 4 publications

References 35 publications

Serum Neopterin Level in Children with Juvenile Idiopathic Arthritis

Serum Neopterin Level in Children with Juvenile Idiopathic Arthritis

Lipopolysaccharide-binding protein, neopterin and interferon-gamma as indices of inflammation activity in patients with acute brucellosis

Dynamics of the detection rate for infectious diseases during blood collection from donors in Russia and factors affecting it

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