Neopterin as assessment marker for susceptibility of silicosis in dental technician

El-Sharkawy, Ahlam M.; Ahmed, Nevien Mahmoud

doi:10.21608/blj.2016.47869

Cited by 2 publications

(3 citation statements)

References 12 publications

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“…Five studies were from African countries. [ 12 13 19 20 22 ] It is noteworthy that among the studies from African countries, four studies were from Egypt. The year of publication of the included studies varied from 1981[ 21 ] to 2016.…”

Section: R Esultsmentioning

confidence: 99%

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Relationship between occupational exposure to respirable crystalline silica and serum copper level as an indicator of silicosis: A systematic review and meta-analysis

Poormohammadi

Ayubi

Assari

et al. 2023

Indian J Occup Environ Med

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Background: This systematic review and meta-analysis study evaluates a relationship between occupational exposure to respirable crystalline silica and serum copper (Cu) levels as an indicator for early detection of silicosis. Materials and Methods: A systematic search was conducted, and the quality of results was evaluated in accordance with the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The following databases were searched, including Web of Sciences, Scopus, and PubMed from inception until November 2021. The following keywords were selected for searching in the mentioned databases including, “copper” OR “serum copper” AND “silicosis”. The mean (standard deviation [SD]) of Cu was extracted for both silicosis and non-silicosis subjects. The differences in mean effect size were pooled using the random-effect model. Heterogeneity and publication bias were evaluated using the I 2 value and Begg's test and Egger's test, respectively. Results: A total of 159 studies were initially found, among which eight studies were included in the meta-analysis. Random-effect meta-analysis of these eight studies showed that silicosis patients had higher copper levels than the non-silicosis group with a pooled standardized mean difference (SMD) of 3.02 (95% confidence interval: 0.25, 5.78); I 2 = 99.3%, P value < 0.001. The subgroup analysis showed that the corresponding figures in those with mean age >40 years and <40 years were 5.79 (2.06, 9.52) and −0.43 (−4.57, 3.70), respectively. Moreover, no publication bias was found in the analyses. Conclusions: The results of the present study demonstrated that silica exposure may be associated with increasing serum Cu levels.

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Section: R Esultsmentioning

confidence: 99%

“…The year of publication of the included studies varied from 1981[ 21 ] to 2016. [ 18 19 ] The total sample size in silicotic and non-silicotic groups was 404 and 546, respectively. There was a high variation in the exposure duration.…”

Section: R Esultsmentioning

confidence: 99%

Relationship between occupational exposure to respirable crystalline silica and serum copper level as an indicator of silicosis: A systematic review and meta-analysis

Poormohammadi

Ayubi

Assari

et al. 2023

Indian J Occup Environ Med

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“…Respiratory diseases as silicosis may increased and associated with Long-term occupational exposure to silica. The primary changes against the silica exposure happen as a result for creation of fibrogenetic and inflammatory mediators as well as growth factors, including tumor necrosis factor 6 .…”

Section: Introductionmentioning

confidence: 99%

Correlation of TNF 308 Polymorphisms and Susceptibility to Respiratory Disease

Dulaimi¹,

Rabee²

2021

Indian Journal of Forensic Medicine & Toxicology

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To estimate the association of TNF-α 308 SNPs with the risk of respiratory disease in Iraqi concrete laborers. 49 concrete laborers and 40 healthy people were taken on our investigation. Technology of Amplification refractory mutational system-polymerase chain reaction (ARMS-PCR) was used to testify single nucleotide polymorphism (SNP) of TNF-α gene. Enzyme-linked immunosorbent assay (ELISA) technique was utilized to measurement the amount of TNF-α protein. odds ratios (ORs) with 95% confidence intervals (CIs) were utilized to estimate the strength of association. Testing for Hardy-Weinberg (H-W) equilibrium revealed both laborers and control showed significant variation in the distribution of TNF-α-308 genotypes (p ≤0.05). Both genotypic and allelic frequency of rs1800629 show in significant difference between concrete laborers and healthy controls. Nevertheless the frequency of A allele was insignificantly increase in laborers (20%) than in controls (14%) (P = 0.077; OR = 1.61; 95% CI = 0.72 to 3.58). After analyzing the relationship between TNF-α serum levels of laborers and genotype of TNF-α-308G/A, we detected the laborers that carrying the GA and AA genotypes had significantly higher levels of TNF-α compared to GG genotype carriers of rs1800629 ( P< 0.01). Consequently, our information proposed that TNF-α-308G/A variation was linked to risk of respiratory disease in concrete laborers. Moreover, we also identified TNF-α-308 A allele was the risk factor for concrete laborers in Iraqi population.

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Neopterin as assessment marker for susceptibility of silicosis in dental technician

Cited by 2 publications

References 12 publications

Relationship between occupational exposure to respirable crystalline silica and serum copper level as an indicator of silicosis: A systematic review and meta-analysis

Relationship between occupational exposure to respirable crystalline silica and serum copper level as an indicator of silicosis: A systematic review and meta-analysis

Correlation of TNF 308 Polymorphisms and Susceptibility to Respiratory Disease

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