Neopterin levels and dexamethasone suppression test in posttraumatic stress disorder

Atmaca, Murad; Kuloğlu, Murat; Tezcan, Ertan; Önal, Süleyman; Üstündağ, Bilal

doi:10.1007/s00406-002-0374-5

Cited by 27 publications

(11 citation statements)

References 30 publications

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“…However, we performed blood sampling 1 h after castration and the action time of lidocaine is about 60 min (Ranheim et al 2005). Cortisol could cause suppression of cell-mediated immunity and consequently could result in decreased neopterin and biopterin concentrations (Atmaca et al 2002). Prunier et al (2005) showed that the increase of plasma cortisol concentration started 15 min after castration of piglets and returned to the pre-castration level within 3 h with peak values occurring between 30 and 60 min after castration.…”

Section: Discussionmentioning

confidence: 99%

Concentrations of neopterin, biopterin, and cortisol associated with surgical castration of piglets with lidocaine

Maršálek¹,

Svoboda²,

Bernardy³

et al. 2015

CZECH J ANIM SCI

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THe effect of surgical castration with local anesthesia using lidocaine on neopterin, biopterin, and cortisol blood plasma concentrations in piglets was studied. THree groups of 12 piglets were investigated: one group castrated without lidocaine, one group castrated with lidocaine, and one group left as an uncastrated control group handled in the same way as castrated piglets. Blood samples were collected 4 min before castration, and 1 h and 24 h after castration. THe time × treatment interaction (P < 0.01) was detected for neopterin concentrations, yielding the result that neopterin was higher (P < 0.01) in castrated piglets without lidocaine 1 h after surgical castration compared with all other groups. THe time effect (P < 0.05) was detected for biopterin concentrations. THe time × treatment interaction (P < 0.01) was detected for plasma cortisol concentrations, yielding the result that neopterin was higher (P < 0.01) in castrated piglets without lidocaine and in castrated piglets with lidocaine 1 h after surgical castration compared with pre-treatment and concentrations 24 h after surgical castration. THe study showed that the use of lidocaine for the surgical castration of piglets may significantly influence the activation of the immune system. THis is corroborated by a significant difference in blood plasma neopterin concentrations between piglets castrated with anesthesia and those castrated without it. THe use of lidocaine had no effect on cortisol concentrations in comparison with the group castrated without lidocaine.

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Section: Discussionmentioning

confidence: 99%

Concentrations of neopterin, biopterin, and cortisol associated with surgical castration of piglets with lidocaine

Maršálek¹,

Svoboda²,

Bernardy³

et al. 2015

CZECH J ANIM SCI

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“…In PTSD, 24-h urinary cortisol was increased (De Bellis et al, 1999;Lemieux and Coe, 1995;Maes et al, 1998;Pitman and Orr, 1990), unchanged (Baker et al, 1999;Rasmusson et al, 2001;Young and Breslau, 2004) or decreased (Thaller et al, 1999;Yehuda et al, 1995Yehuda et al, , 1990 compared to healthy controls. Also, cortisol suppression after dexamethasone was reported to be diminished (Atmaca et al, 2002;Thaller et al, 1999), unchanged (Dinan et al, 1990;Halbreich et al, 1989;Lindley et al, 2004;Lipschitz et al, 2003), or to be enhanced (Stein et al, 1997;Yehuda et al, 2002Yehuda et al, , 1993. Some of these inconsistencies might be related to differences among studies regarding the study population, age, and gender differences, use of psychotropic medication, comorbid substance abuse, and dose of dexamethasone (for reviews, see Rasmusson et al, 2003;Yehuda, 2002).…”

Section: Introductionmentioning

confidence: 99%

Hypothalamic–Pituitary–Adrenal Axis Activity and Sleep in Posttraumatic Stress Disorder

Otte

Lenoci

Metzler

et al. 2005

Neuropsychopharmacol

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Alterations of the hypothalamic-pituitary-adrenal (HPA) axis and sleep disturbances have been described separately in post-traumatic stress disorder (PTSD). It is not known if HPA alterations and sleep disturbances are associated in PTSD. This study examined sleep and HPA activity in 20 male medication-free subjects with PTSD and 16 matched healthy controls. Two nights of polysomnography were obtained and 24-h urinary cortisol was collected during day 2. Subjects self-administered a low-dose (0.5 mg) salivary dexamethasone test at home. Compared with controls, PTSD subjects had higher 24-h urinary mg cortisol/g creatinine (mean7SD 40717 vs 28712, p ¼ 0.03) but not significantly higher 24-h urinary cortisol (mean7SD 52715 mg/day vs 43723, p ¼ 0.19). PTSD subjects showed a trend towards less cortisol suppression after dexamethasone (73%718 vs 83%710, p ¼ 0.06). In the combined sample, delta sleep was significantly and negatively correlated with 24-h urinary cortisol (r ¼ À0.36, p ¼ 0.04), and with 24-h urinary cortisol/g creatinine on a trend level (r ¼ À0.34, p ¼ 0.06). Our results suggest that increased cortisol is negatively associated with delta sleep. This may contribute to sleep abnormalities in conditions associated with elevated cortisol, possibly including PTSD. Future studies should explore the temporal relationship between HPA activity, sleep disturbances, and psychopathology after a traumatic event.

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“…Glucocorticoids may also play a role in influencing pterin synthesis. Glucocorticoids could cause suppression of cellmediated immunity and consequently could result in decreased pterin concentrations as observed in human medicine (Atmaca et al, 2002;Kuloglu et al, 2007). The defense mechanisms of avian species are generally comparable with those of mammals, despite the fundamental differences in system structures.…”

Section: Discussionmentioning

confidence: 96%

“…Similarly, Smutna et al (2010) and Marsalek et al (2011) found elevated neopterin levels due to acute stress in pigs. On the contrary, clinical studies on stress in humans showed that glucocorticoids could cause suppression of cell-mediated immunity and consequently could result in decreased neopterin and biopterin concentrations (Atmaca et al, 2002;Kuloglu et al, 2007).…”

Section: Faculty Of Veterinary Hygiene and Ecology University Of Vetmentioning

confidence: 97%

Neopterin and biopterin as biomarkers of immune system activity associated with crating in broiler chickens

et al. 2014

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Neopterin and biopterin belong to a group of unconjugated pterin derivates. These biomolecules are present in many animal species and perform several functions. Pterin concentrations may provide additional information on the effect of stress on immune system activity. This study focused on an investigation of the effect of crating on plasma concentrations of neopterin and biopterin in broilers. The effects of 2 crating periods (2 and 4 h) were monitored in Hubbard broilers (n = 90) aged 42 d. After a given crating period, randomly selected chickens from each group were sampled immediately and the remaining chickens were sampled after 24 h. Plasma corticosterone increased (P < 0.001) immediately after 2 and 4 h crating, but no difference between the crated and the control noncrated broilers was found 24 h later. Immediately after crating, neopterin in 2- and 4-h broilers did not differ from the control, but 24 h later a decrease (P = 0.011) in plasma neopterin was found in 4-h broilers compared with the control. Simultaneously, 24 h after crating, neopterin levels in 2- and 4-h broilers decreased (P < 0.001) in comparison with the levels immediately after crating. Plasma biopterin was higher (P < 0.001) in 4-h broilers than in the control immediately after the crating. A time of sampling effect (P = 0.016) was found for the heterophil-to-lymphocyte ratio, with heterophil-to-lymphocyte ratio higher 24 h after crating in comparison with its level immediately after the crating. This study shows that crating may significantly affect the immune system of broiler chickens. This is corroborated by the increase in plasma biopterin concentrations in broilers immediately after crating and the decrease in plasma neopterin concentrations in broilers 24 h after crating. The correlations were found for widely used indicators of acute and chronic stress in birds [i.e., plasma corticosterone concentrations (biopterin) and the heterophil-to-lymphocyte ratio (neopterin), respectively].

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Neopterin levels and dexamethasone suppression test in posttraumatic stress disorder

Cited by 27 publications

References 30 publications

Concentrations of neopterin, biopterin, and cortisol associated with surgical castration of piglets with lidocaine

Concentrations of neopterin, biopterin, and cortisol associated with surgical castration of piglets with lidocaine

Hypothalamic–Pituitary–Adrenal Axis Activity and Sleep in Posttraumatic Stress Disorder

Neopterin and biopterin as biomarkers of immune system activity associated with crating in broiler chickens

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