Neosartorya hiratsukae peritonitis through continuous ambulatory peritoneal dialysis

Koutroutsos, Konstantinos; Arabatzis, Michael; Bougatsos, George; Xanthaki, Anna; Toutouza, Marina; Velegraki, Aristea

doi:10.1099/jmm.0.019133-0

Cited by 16 publications

(18 citation statements)

References 14 publications

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“… References T max : a Houbraken (unpublished); b Pitt ( 1979 ); c Domsch and colleagues ( 1980 ); d Koutroutsos and colleagues ( 2010 ); e Malejczyk and colleagues ( 2013 ); f Stolk and Samson ( 1972 ); g Morgenstern and colleagues ( 2012 ). The proportions of sugars are based on their occurrence in HPLC profiles in which the pure (oligo)saccharides were used for calibration.…”

Section: Resultsmentioning

confidence: 99%

Functionality and prevalence of trehalose‐based oligosaccharides as novel compatible solutes in ascospores of Neosartorya fischeri (Aspergillus fischeri) and other fungi

Wyatt

Leeuwen

Golovina

et al. 2014

Environmental Microbiology

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Ascospores of Neosartorya, Byssochlamys and Talaromyces can be regarded as the most stress-resistant eukaryotic cells. They can survive exposure at temperatures as high as 85°C for 100 min or more. Neosartorya fischeri ascospores are more viscous and more resistant to the combined stress of heat and desiccation than the ascospores of Talaromyces macrosporus which contain predominantly trehalose. These ascospores contain trehalose-based oligosaccharides (TOS) that are novel compatible solutes, which are accumulated to high levels. These compounds are also found in other members of the genus Neosartorya and in some other genera within the order Eurotiales that also include Byssochlamys and Talaromyces. The presence of oligosaccharides was observed in species that had a relatively high growth temperature. TOS glasses have a higher glass transition temperature (Tg) than trehalose, and they form a stable glass with crystallizing molecules, such as mannitol. Our data indicate that TOS are important for prolonged stabilization of cells against stress. The possible unique role of these solutes in protection against dry heat conditions is discussed.

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Section: Resultsmentioning

confidence: 99%

Functionality and prevalence of trehalose‐based oligosaccharides as novel compatible solutes in ascospores of Neosartorya fischeri (Aspergillus fischeri) and other fungi

Wyatt

Leeuwen

Golovina

et al. 2014

Environmental Microbiology

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“…Apart from A. fumigatus, several species within Aspergillus section Fumigati have been implicated in different human infections, namely, Aspergillus lentulus (Alhambra et al, 2008;Montenegro et al, 2009), Aspergillus viridinutans (Vinh et al, 2009a;Coelho et al, 2011), Neosartorya fischeri (Lonial et al, 1997), Neosartorya pseudofischeri (Padhye et al, 1994), Neosartorya spinosa (Summerbell et al, 1992), Neosartorya hiratsukae (Guarro et al, 2002;Koutroutsos et al, 2010) and Neosartorya udagawae (Vinh et al, 2009b;Posteraro et al, 2011). Different Aspergillus species seem to be simultaneously involved in several such infections (Alhambra et al, 2008;Montenegro et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Invasive aspergillosis caused by cryptic Aspergillus species: a report of two consecutive episodes in a patient with leukaemia

Peláez

Álvarez‐Pérez

Mellado

et al. 2013

Journal of Medical Microbiology

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We report a case of two consecutive episodes of invasive aspergillosis caused by cryptic Aspergillus species in a patient with leukaemia. A first episode of pulmonary infection was caused by Aspergillus calidoustus and Aspergillus novofumigatus, and the second episode by A. novofumigatus and Aspergillus viridinutans. Fungal isolates were identified to species level using traditional and sequencing-based molecular methods.

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“…Aspergillus fumigatus belongs to the Fumigati section, where there are other species that are indistinguishable by means of classical identification methods. Within this complex, besides A. fumigatus, other species such as Aspergillus lentulus, Neosartorya udagawae, Neosartorya pseudofischeri, Neosartorya hiratsukae and Aspergillus viridinutants have been reported in human infections [2][3][4][5][6][7][8][9]. Aspergillus lentulus was first described in 2005, isolated from neutropenic patients with a fatal outcome [3].…”

Section: Introductionmentioning

confidence: 99%

Three-dimensional models of 14α-sterol demethylase (Cyp51A) from Aspergillus lentulus and Aspergillus fumigatus: an insight into differences in voriconazole interaction

Alcàzar-Fuoli

Cuesta

Rodríguez-Tudela

et al. 2011

International Journal of Antimicrobial Agents

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Aspergillus lentulus, an Aspergillus fumigatus sibling species, is increasingly reported in corticosteroid-treated patients. Its clinical significance is unknown, but the fact that A. lentulus shows reduced antifungal susceptibility, mainly to voriconazole, is of serious concern. Heterologous expression of cyp51A from A. fumigatus and A. lentulus was performed in Saccharomyces cerevisiae to assess differences in the interaction of Cyp51A with the azole drugs. The absence of endogenous ERG11 was efficiently complemented in S. cerevisiae by the expression of either Aspergillus cyp51A allele. There was a marked difference between azole minimum inhibitory concentration (MIC) values of the clones expressing each Aspergillus spp. cyp51A. Saccharomyces cerevisiae clones expressing A. lentulus alleles showed higher MICs to all of the azoles tested, supporting the hypothesis that the intrinsic azole resistance of A. lentulus could be associated with Cyp51A. Homology models of A. fumigatus and A. lentulus Cyp51A protein based on the crystal structure of Cyp51p from Mycobacterium tuberculosis in complex with fluconazole were almost identical owing to their mutual high sequence identity. Molecular dynamics (MD) was applied to both three-dimensional protein models to refine the homology modelling and to explore possible differences in the Cyp51A-voriconazole interaction. After 20ns of MD modelling, some critical differences were observed in the putative closed form adopted by the protein upon voriconazole binding. A closer study of the A. fumigatus and A. lentulus voriconazole putative binding site in Cyp51A suggested that some major differences in the protein's BC loop could differentially affect the lock-up of voriconazole, which in turn could correlate with their different azole susceptibility profiles.

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Neosartorya hiratsukae peritonitis through continuous ambulatory peritoneal dialysis

Cited by 16 publications

References 14 publications

Functionality and prevalence of trehalose‐based oligosaccharides as novel compatible solutes in ascospores of Neosartorya fischeri (Aspergillus fischeri) and other fungi

Functionality and prevalence of trehalose‐based oligosaccharides as novel compatible solutes in ascospores of Neosartorya fischeri (Aspergillus fischeri) and other fungi

Invasive aspergillosis caused by cryptic Aspergillus species: a report of two consecutive episodes in a patient with leukaemia

Three-dimensional models of 14α-sterol demethylase (Cyp51A) from Aspergillus lentulus and Aspergillus fumigatus: an insight into differences in voriconazole interaction

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