Neospora caninum infection in aborting bovines and lost fetuses: A systematic review and meta-analysis

Nayeri, Tooran; Moosazadeh, Mahmood; Sarvi, Shahabeddin; Daryani, Ahmad

doi:10.1371/journal.pone.0268903

Cited by 17 publications

(12 citation statements)

References 102 publications

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“…The presence and spread of bovine neosporosis have been reported in more than 34 countries from Europe, Asia, America and Australia ( 13 ). However, few studies have investigated the prevalence of N. caninum infection in African countries ( 14 ). Toxoplasma gondii has been isolated from almost all geographical regions worldwide except Antarctica ( 15 ).…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence and risk factors analysis of Neospora caninum and Toxoplasma gondii in cattle of Beheira, Egypt

Metwally

Hamada²,

Sobhy³

et al. 2023

Front. Vet. Sci.

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IntroductionNeospora caninum and Toxoplasma gondii are closely related obligate intracellular protozoan parasites. They are considered to be the major causes of infectious abortions and congenital abnormalities in livestock worldwide resulting in huge economic losses. Currently, there are no reports on the prevalence of neosporosis or toxoplasmosis in cattle in Beheira, Egypt's most important region for cattle industry.MethodsThe current study investigated the presence of anti-N. caninum and anti-T. gondii antibodies in apparent healthy cattle from eight localities representing the whole area of Beheira. A total of 358 plasma samples were randomly collected from 6 dairy and 10 beef farms and analyzed by commercially available ELISAs. Production type (dairy versus beef), sex (female vs male), age (< 3 years, 3–5, and > 5 years old), breed (mixed vs Holstein vs Colombian Zebu), and location (various locations) were assessed as risk factors for N. caninum and T. gondii infections.Results and discussionOf the samples, 88 (24.6%) and 19 (5.3%) were positive for anti-N. caninum and anti-T. gondii antibodies, respectively, and mixed infection was detected in 7. Of the 16 herds, 6 dairy and 7 beef herds were positive for antibodies to N. caninum. Antibodies to T. gondii were detected in 4, and 5 of dairy and beef herds, respectively. Production type (dairy) and, therewith, sex (female), age (aged over 5 years), and location were considered as risk factors for N. caninum infection. No factors statistically associated with T. gondii infection were identified. Overall, this study provided the first serological detection of N. caninum and T. gondii infections in cattle from Beheira, demonstrating the endemicity of both parasites in the main cattle rearing region of Egypt. This study also confirmed earlier reports of N. caninum being more present in dairy cattle than in beef cattle. Routine monitoring of N. caninum and T. gondii infections and the implementation of control strategies are urgently needed.

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Section: Introductionmentioning

confidence: 99%

Seroprevalence and risk factors analysis of Neospora caninum and Toxoplasma gondii in cattle of Beheira, Egypt

Metwally

Hamada²,

Sobhy³

et al. 2023

Front. Vet. Sci.

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“…Therefore, we hypothesize that the aetiologies reported in the Tanzanian study may also be responsible for abortions in these areas [ 4 ]. This is especially Neospora caninum , a known major cause of reproductive failure in cattle herds practicing stall-feeding production systems around the world [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Higher livestock abortion burden in arid and semi-arid lands, Kenya, 2019–2020

Gachohi,

Njoki,

Mogoa

et al. 2024

PLoS ONE

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Tracking livestock abortion patterns over time and across factors such as species and agroecological zones (AEZs) could inform policies to mitigate disease emergence, zoonoses risk, and reproductive losses. We conducted a year-long population-based active surveillance of livestock abortion between 2019 and 2020, in administrative areas covering 52% of Kenya’s landmass and home to 50% of Kenya’s livestock. Surveillance sites were randomly selected to represent all AEZs in the country. Local animal health practitioners electronically transmitted weekly abortion reports from each ward, the smallest administrative unit, to a central server, using a simple short messaging service (SMS). Data were analyzed descriptively by administrative unit, species, and AEZ to reveal spatiotemporal patterns and relationships with rainfall and temperature. Of 23,766 abortions reported in all livestock species, sheep and goats contributed 77%, with goats alone contributing 53%. Seventy-seven per cent (n = 18,280) of these abortions occurred in arid and semi-arid lands (ASALs) that primarily practice pastoralism production systems. While spatiotemporal clustering of cases was observed in May-July 2019 in the ASALs, there was a substantial seasonal fluctuation across AEZs. Kenya experiences high livestock abortion rates, most of which go unreported. We recommend further research to document the national true burden of abortions. In ASALs, studies linking pathogen, climate, and environmental surveillance are needed to assign livestock abortions to infectious or non-infectious aetiologies and conducting human acute febrile illnesses surveillance to detect any links with the abortions.

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“…Neosporosis is one of important cause for abortion and reproductive abnormalities in vulnerable animal around the world, resulting in significant economic losses, notably among ruminants [1][2][3] . It is a worldwide parasitic disease caused by Neospora caninum, protozoan apicomplexan that includes canids as definitive hosts while birds and numerous species of mammals as intermediate hosts 4,5 .…”

Section: Serosurvey and Associated Risk Factors For Neospora Caninum ...mentioning

confidence: 99%

Serosurvey and associated risk factors for Neospora caninum infection in Egyptian water buffaloes (Bubalus bubalis)

Alshammari,

Marzok,

Gattan

et al. 2023

Sci Rep

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Neosporosis is a parasitic disease that causes reproductive disorders in animals, making it a barrier to maximum efficiency. The purpose of this study was to determine the seroprevalence ofNeosporacaninum(N.caninum) antibodies in water buffaloes from four governorates in northern Egypt. A commercial indirect-ELISA test was used to detect antibodies againstN.caninumin the serum of 450 water buffaloes. The total seroprevalence ofN.caninumin water buffaloes from Egypt was 31.3%, and the highest prevalence was observed in Gharbia governorate. The identified risk factors forN.caninuminfections in water buffaloes were sex (OR = 1.96, 95%CI: 1.22−4.17), buffaloes more than 4 years of age ( OR = 5.80, 95%CI: 2.26−14.86), abortion in second trimester (OR = 16.48, 95%%CI: 2.99−34.03), history of abortion (OR = 3.45, 95%CI: 1.58−7.52) and contact with dogs (OR = 2.55, 95%CI: 1.51−4.32). Thus, more studies are needed to determine the role of buffaloes in the epidemiology of neosporosis in Egypt.

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Neospora caninum infection in aborting bovines and lost fetuses: A systematic review and meta-analysis

Cited by 17 publications

References 102 publications

Seroprevalence and risk factors analysis of Neospora caninum and Toxoplasma gondii in cattle of Beheira, Egypt

Seroprevalence and risk factors analysis of Neospora caninum and Toxoplasma gondii in cattle of Beheira, Egypt

Higher livestock abortion burden in arid and semi-arid lands, Kenya, 2019–2020

Serosurvey and associated risk factors for Neospora caninum infection in Egyptian water buffaloes (Bubalus bubalis)

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