Neospora caninum tachyzoites inoculated by the conjunctival route are not vertically transmitted in pregnant cattle: A descriptive study

Moore, D.P.; Álvarez‐García, Gema; Chiapparrone, María Laura; Regidor‐Cerrillo, Javier; Lischinsky, L.; Yaniz, M.G. de; Odeón, Anselmo Carlos; Ortega‐Mora, Luis Miguel; Campero, Carlos Manuel

doi:10.1016/j.vetpar.2013.10.006

Cited by 6 publications

(2 citation statements)

References 42 publications

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“…Inoculation of tachyzoites through the conjunctiva, at doses of 1 and 2•5 × 10 8 , resulted in infection and induction of a specific immune response in pregnant cattle without causing transplacental transmission of the parasite to the foetus (de Yaniz et al 2007;Moore et al 2014). Cows infected with the lower dose even reverted to seronegative status 4 months after infection (de Yaniz et al 2007).…”

Section: Initiatives For Model Harmonization In N Caninum Infectionmentioning

confidence: 99%

Experimental ruminant models for bovine neosporosis: what is known and what is needed

et al. 2014

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At present, bovine neosporosis is an important worldwide concern because of its wide geographic distribution and economic impact. Abortion is the main clinical sign of bovine neosporosis in both dairy and beef cattle. Ruminant challenge models are critical to evaluate potential vaccine candidates to help tackle bovine neosporosis and to study pathogenesis and host responses to infection. Several research groups have developed ruminant models of Neospora caninum infection independently of others, resulting in a high degree of variability due to the use of different species of animals, breeds, strains/isolates of N. caninum, doses, routes and times of inoculation. Standardization is greatly needed to advance research in a more collaborative, timely and efficient manner. In the absence of widely accepted international guidelines, this manuscript serves to summarize and discuss the different models and parameters currently in use. Parameters essential for the development of non-pregnant and pregnant ruminant models are outlined and the main knowledge gaps are identified. This information could act as the basis to develop a consensus for international standard guidelines for ruminant models of neosporosis that would be helpful for researchers in this field worldwide.

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Section: Initiatives For Model Harmonization In N Caninum Infectionmentioning

confidence: 99%

Experimental ruminant models for bovine neosporosis: what is known and what is needed

et al. 2014

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“…In the majority of the studies, the inocula consisted of tachyzoites propagated in cell culture. Tachyzoites have been inoculated in cows by different routes, such as intravenous (IV), subcutaneous (SC), intramuscular (IM), intra-uterine, and conjunctival ( 18 – 21 ). Sporulated oocysts were employed as inoculum for pregnant cows in only three studies and the cows were inoculated orally ( 22 – 24 ).…”

Section: Introductionmentioning

confidence: 99%

Experimental Neospora caninum Infection in Pregnant Cattle: Different Outcomes Between Inoculation With Tachyzoites and Oocysts

Gondim

McAllister

2022

Front. Vet. Sci.

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Neospora caninum is a globally distributed abortifacient protozoan of cattle. Experimental infections with N. caninum in cattle have provided valuable information on host-parasite interaction and immunopathogenesis. Experimental infection of pregnant cows has been reported in about 20 articles, with most studies using cultured parasite tachyzoites as the inoculum. Only three experimental studies have been conducted in pregnant cows using the parasite's oocysts which are shed by dogs, in large part because transmission experiments using oocysts take more time and are more complex and expensive than experiments using tachyzoites. In this minireview, we discuss differences between N. caninum tachyzoites and oocysts as inocula for experimental infection of pregnant cows, as well as the route animals are inoculated.

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Antibody seropositivity for Neospora caninum in Blanco Orejinegro cattle in Colombia and factors associated with the infection

Corrales

Herrera

et al. 2021

Trop Anim Health Prod

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Neospora caninum tachyzoites inoculated by the conjunctival route are not vertically transmitted in pregnant cattle: A descriptive study

Cited by 6 publications

References 42 publications

Experimental ruminant models for bovine neosporosis: what is known and what is needed

Experimental ruminant models for bovine neosporosis: what is known and what is needed

Experimental Neospora caninum Infection in Pregnant Cattle: Different Outcomes Between Inoculation With Tachyzoites and Oocysts

Antibody seropositivity for Neospora caninum in Blanco Orejinegro cattle in Colombia and factors associated with the infection

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