Neospora caninum truncated recombinant proteins formulated with liposomes and CpG-ODNs triggered a humoral immune response in cattle after immunisation and challenge

Novoa, María Belén; Sarli, Macarena; Reidel, Ivana Gabriela; Veaute, Carolina; Valentini, Beatriz; Primo, María Evangelina

doi:10.1016/j.vetimm.2021.110285

Cited by 4 publications

(1 citation statement)

References 57 publications

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“…Recently, Camussone et al [ 106 ] successfully evaluated the ability of a subunit vaccine composed of four recombinant molecules formulated with cationic liposomes and CpG oligodeoxynucleotides to confer protection against Staphylococcus aureus intra-mammary infections in heifers and cows. Cationic liposomes and CpG oligodeoxynucleotides were also used as adjuvants to improve the immunogenicity of a truncated recombinant protein-based vaccine targeting Neospora caninum in cattle, and it proved also to enhance the humoral immune response after challenge [ 107 ].…”

Section: Theranostic Nucleotidementioning

confidence: 99%

Nucleotides Entrapped in Liposome Nanovesicles as Tools for Therapeutic and Diagnostic Use in Biomedical Applications

et al. 2023

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The use of nucleotides for biomedical applications is an old desire in the scientific community. As we will present here, there are references published over the past 40 years with this intended use. The main problem is that, as unstable molecules, nucleotides require some additional protection to extend their shelf life in the biological environment. Among the different nucleotide carriers, the nano-sized liposomes proved to be an effective strategic tool to overcome all these drawbacks related to the nucleotide high instability. Moreover, due to their low immunogenicity and easy preparation, the liposomes were selected as the main strategy for delivery of the mRNA developed for COVID-19 immunization. For sure this is the most important and relevant example of nucleotide application for human biomedical conditions. In addition, the use of mRNA vaccines for COVID-19 has increased interest in the application of this type of technology to other health conditions. For this review article, we will present some of these examples, especially focused on the use of liposomes to protect and deliver nucleotides for cancer therapy, immunostimulatory activities, enzymatic diagnostic applications, some examples for veterinarian use, and the treatment of neglected tropical disease.

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Section: Theranostic Nucleotidementioning

confidence: 99%