Neostigmine Counteracts Spinal Clonidine-induced Hypotension in Sheep

Evaluation of intrathecal neostigmine in different doses added to bupivacaine for postoperative analgesia

“…4 Neostigmine has been shown to counteract haemodynamic effects of clonidine and bupivacaine. 5,6 Considering the above facts, we designed the present study to evaluate efficacy and safety of intrathecal bupivacaine alone and in combination with neostigmine for postoperative analgesia.…”

Effects of epidural clonidine and neostigmine following intrathecal labour analgesia: a randomised, double-blind, placebo-controlled trial

“…20,40 Secondly, a haemodynamic advantage is possible resulting from opposite effects on the sympathetic nervous system. 24,41 However these effects were observed following intrathecal administration and, to our knowledge, no similar effects were demonstrated following epidural administration.…”

The Efficacy of Thoracic Epidural Neostigmine Infusion After Thoracotomy

“…In animal research, it has been suggested that blockade for a successful reversal of established hypersensitivity should be stronger in intensity and longer in duration than a preemptive effect to prevent establishment because the intensity of afferent input for reinitiation of central hypersensitivity is less than that for its initiation (22). Many experiments indicate that spinally administered neostigmine increases arterial blood pressure and heart rate, an effect possibly mediated by activating preganglionic sympathetic neurons (23,24). In 2 healthy volunteers, intrathecal injection of 750 g neostigmine was associated with increased arterial blood pressure and heart rate; however, the mechanism for these increases is unknown (1).…”