Neovagina creation methods in Müllerian anomalies and risk of malignancy: insights from a systematic review

Fedele, Francesco; Bulfoni, A; Parazzini, Fabio; Busnelli, Andrea

doi:10.1007/s00404-023-07086-6

Cited by 1 publication

(2 citation statements)

References 41 publications

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“…However, most papers on the application of these materials have been case reports, and all of these materials (except the skin and the peritoneum) require the application of allografts. Furthermore, a neovagina that uses skin as a covering can still maintain keratinized epithelial cells, sebaceous glands, and hair even 2 years after the operation ( 5 ). In our study, a peritoneal flap was applied instead of other allografts or skin grafts, which might help to reduce the additional damage to the uterus and decrease the expense of surgery.…”

Section: Discussionmentioning

confidence: 99%

“…Complete vaginal atresia is usually associated with cervical dysplasia or cervical atresia ( 1 , 3 , 4 ). Currently, the main surgical method for patients with complete vaginal atresia is vaginoplasty with or without sparing of the uterus ( 5 , 6 ). However, hysterectomy places a massive physical and mental burden on young females and their families ( 7 , 8 ).…”

Section: Introductionmentioning

confidence: 99%

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Efficacy and safety of laparoscopic vaginoplasty with peritoneal flaps and cervicoplasty in patients with congenital cervical and complete vaginal atresia: a pilot study

Liu,

Zhang,

Wang

et al. 2024

Quant Imaging Med Surg

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Background Hysterectomy places a considerable physical and mental burden on young female patients with congenital cervical and complete vaginal atresia. Thus, it is necessary to develop a method to detach the obstruction and simultaneously preserve the vagina and uterus in these patients. This study sought to evaluate the efficacy and safety of laparoscopic vaginoplasty using peritoneal flaps and cervicoplasty in patients with congenital cervical and complete vaginal atresia. Methods Between April 2013 and June 2022, nine patients with congenital cervical and complete vaginal atresia at Henan Provincial People’s Hospital were enrolled in this prospective study. All patients were treated with laparoscopic vaginoplasty using peritoneal flaps and cervicoplasty. Baseline clinical data (e.g., age and uterus size) were collected. The surgical success rate and adverse events were assessed. Results The nine enrolled patients had a median age of 15.0 [interquartile range (IQR), 14.0–18.0] years, and five of these patients had pelvic adhesions. The surgeries were successful in all (9/9) patients, with the vagina, uterus, and a normal menstrual cycle being preserved. After a median follow-up duration of 48 months, the neovaginas had a median length of 7.5 cm. Postoperative complications occurred in three of patients and were cured with the appropriate treatment. The five married patients reported being satisfied with their sex life. Conclusions The study preliminarily demonstrated the efficacy of laparoscopic vaginoplasty using peritoneal flaps and cervicoplasty in patients with congenital cervical and complete vaginal atresia. However, due to the small sample size, lack of a control group, and relatively high incidence of adverse events, further studies are still needed to verify these results. Regardless, our findings establish an approach for preserving both the vagina and uterus for patients with congenital cervical and complete vaginal atresia.

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Section: Discussionmentioning

confidence: 99%