Neovascularization and the appearance of morphological characteristics of the blood-brain barrier in the embryonic mouse central nervous system

Bauer, Hannelore; Bauer, H.; Lametschwandtner, Alois; Amberger, Albert; Ruiz, Phillip; Steiner, Marianne

doi:10.1016/0165-3806(93)90031-5

Cited by 122 publications

(84 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In one study, selective experimental injury to astrocytes during the first postnatal week did not prevent endothelial cell expression of blood-brain barrier-associated markers including ␥-glutamyltranspeptidase and endothelial barrier antigen (EBA) (Krum, 1996). Early in embryonal development the invasion of the intraneuronal tissue by the perineural mesenchymal endothelial cells is accompanied by pericytes (Bauer et al, 1993). The subsequent transformation of endothelial cell junctional complexes into tight junctions is also associated with pericyte coverage.…”

Section: Blood-brain Barrier Differentiation and Angiogenesismentioning

confidence: 97%

Role of the CNS microvascular pericyte in the blood-brain barrier

1998

View full text Add to dashboard Cite

Pericytes are a very important cellular constituent of the blood-brain barrier. They play a regulatory role in brain angiogenesis, endothelial cell tight junction formation, blood-brain barrier differentiation, as well as contribute to the microvascular vasodynamic capacity and structural stability. Central nervous system pericytes express macrophage functions and are actively involved in the neuroimmune network operating at the blood-brain barrier. They exhibit unique functional characteristics critical for the pathogenesis of a number of cerebrovascular, neurodegenerative, and neuroimmune diseases.

show abstract

Section: Blood-brain Barrier Differentiation and Angiogenesismentioning

confidence: 97%

Role of the CNS microvascular pericyte in the blood-brain barrier

1998

View full text Add to dashboard Cite

show abstract

“…This plexus provides essential nutrients and oxygen to the developing neural tissue, and it is the source of vascular sprouts that subsequently invade and metabolically support the neural tissue. These PNVP-derived vessels go on to form the bloodbrain barrier that is critical to proper CNS function in the adult (Bar, 1980;Risau, 1986;Risau and Wolburg, 1990;Bauer et al, 1993). Although the invasion of angiogenic sprouts into neural tissue has been described, the developmental processes that pattern the PNVP have not been investigated.…”

Section: Introductionmentioning

confidence: 99%

The neural tube patterns vessels developmentally using the VEGF signaling pathway

et al. 2004

View full text Add to dashboard Cite

Embryonic blood vessels form in a reproducible pattern that interfaces with other embryonic structures and tissues, but the sources and identities of signals that pattern vessels are not well characterized. We hypothesized that the neural tube provides vascular patterning signal(s) that direct formation of the perineural vascular plexus (PNVP) that encompasses the neural tube at mid-gestation. Both surgically placed ectopic neural tubes and ectopic neural tubes engineered genetically were able to recruit a vascular plexus, showing that the neural tube is the source of a vascular patterning signal. In mouse-quail chimeras with the graft separated from the neural tube by a buffer of host cells, graft-derived vascular cells contributed to the PNVP,indicating that the neural tube signal(s) can act at a distance. Murine neural tube vascular endothelial growth factor A (VEGFA) expression was temporally and spatially correlated with PNVP formation, suggesting it is a component of the neural tube signal. A collagen explant model was developed in which presomitic mesoderm explants formed a vascular plexus in the presence of added VEGFA. Co-cultures between presomitic mesoderm and neural tube also supported vascular plexus formation, indicating that the neural tube could replace the requirement for VEGFA. Moreover, a combination of pharmacological and genetic perturbations showed that VEGFA signaling through FLK1 is a required component of the neural tube vascular patterning signal. Thus, the neural tube is the first structure identified as a midline signaling center for embryonic vascular pattern formation in higher vertebrates, and VEGFA is a necessary component of the neural tube vascular patterning signal. These data suggest a model whereby embryonic structures with little or no capacity for angioblast generation act as a nexus for vessel patterning.

show abstract

“…The meninges consist of three distinct mesenchymal cell layers with different functions that form via differentiation of the immature meningeal fibroblasts of neural crest origin. The inner meningeal layer, the pia, produces the basement membrane (BM) covering the cortex and serves as the origin of blood vessels that supply the superficial cerebral cortex (18)(19)(20). The middle meningeal layer, the arachnoid, includes specialized structures called arachnoid granulations, which resorb cerebrospinal fluid after circulation through the ventricular system (21).…”

mentioning

confidence: 99%

Cortical dysplasia and skull defects in mice with a Foxc1 allele reveal the role of meningeal differentiation in regulating cortical development

Zarbalis

Siegenthaler

Choe

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

110

126

View full text Add to dashboard Cite

We report the identification of a hypomorphic mouse allele for Foxc1 (Foxc1 hith ) that survives into adulthood revealing previously unknown roles for Foxc1 in development of the skull and cerebral cortex. This line of mice was recovered in a forward genetic screen using ENU mutagenesis to identify mutants with cortical defects. In the hith allele a missense mutation substitutes a Leu for a conserved Phe at amino acid 107, leading to destabilization of the protein without substantially altering transcriptional activity. Embryonic and postnatal histological analyses indicate that diminished Foxc1 protein expression in all three layers of meningeal cells in Foxc1 hith/hith mice contributes to the cortical and skull defects in mutant mice and that the prominent phenotypes appear as the meninges differentiate into pia, arachnoid, and dura. Careful analysis of the cortical phenotypes shows that Foxc1 hith/hith mice display detachment of radial glial endfeet, marginal zone heterotopias, and cortical dyslamination. These abnormalities have some features resembling defects in type 2 (cobblestone) lissencephaly or congenital muscular dystrophies but appear later in corticogenesis because of the delay in breakdown of the basement membrane. Our data reveal that the meninges regulate the development of the skull and cerebral cortex by controlling aspects of the formation of these neighboring structures. Furthermore, we provide evidence that defects in meningeal differentiation can lead to severe cortical dysplasia.genetic screen ͉ meninges ͉ migration

show abstract

Neovascularization and the appearance of morphological characteristics of the blood-brain barrier in the embryonic mouse central nervous system

Cited by 122 publications

References 28 publications

Role of the CNS microvascular pericyte in the blood-brain barrier

Role of the CNS microvascular pericyte in the blood-brain barrier

The neural tube patterns vessels developmentally using the VEGF signaling pathway

Cortical dysplasia and skull defects in mice with a Foxc1 allele reveal the role of meningeal differentiation in regulating cortical development

Contact Info

Product

Resources

About