Neovascularization Driven by MicroRNA Delivery to the Endothelium

Cheng, Henry S.; Fish, Jason E.

doi:10.1161/atvbaha.115.306558

Cited by 4 publications

(3 citation statements)

References 21 publications

(24 reference statements)

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“…Delivery of miR-126 to the ECs of vessels in ischemic rat hind limb with this method resulted in downregulation of known miR-126 target genes only in ECs and not in liver and spleen as common off-target organs, and increased vessel length, vascular density, and tissue perfusion [160] . UTMD is shown to be an efficient cell-specific method of miRNA delivery and less invasive in comparison to other delivery methods [13] . Although the study was performed in the model of hind limb ischemia, it is likely that it can also be applied to study the effect of miRNA delivery to cardiac ECs in the context of pathological remodeling.…”

Section: Angiogenic Ncrnas As Potential Therapeutic Targets For Heartmentioning

confidence: 99%

“…Despite the conflicting results from past and ongoing clinical trials, pre-clinical in vivo studies show clear improved cardiac function after neovascularization by enhancing capillary density with pro-angiogenic compounds [9] , [10] , [11] . One of the possible reasons for this discrepancy is the common use of single pro-angiogenic agents, mostly considered insufficient to boost angiogenesis in the heart [12] , [13] .…”

Section: Introductionmentioning

confidence: 99%

“…MicroRNAs (miRNAs) are short non-coding RNAs (ncRNAs), 21–23 nucleotide-long that function by repressing the expression of their target genes [13] , [14] . miRNAs are able to bind complementarily to the 3′ untranslated region (UTR) of more than one hundred target messenger RNAs (mRNAs) [15] , [16] involved in regulating common or diverse networks or pathways, allowing the occurrence of a synergistic effect.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Regulation of microvascularization in heart failure - an endothelial cell, non-coding RNAs and exosome liaison

Juni

Abreu

Martins

2017

Non-coding RNA Research

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Heart failure is a complex syndrome involving various pathophysiological processes. An increasing body of evidence shows that the myocardial microvasculature is essential for the homeostasis state and that a decompensated heart is associated with microvascular dysfunction as a result of impaired endothelial angiogenic capacity. The intercellular communication between endothelial cells and cardiomyocytes through various signaling molecules, such as vascular endothelial growth factor, nitric oxide, and non-coding RNAs is an important determinant of cardiac microvascular function. Non-coding RNAs are transported from endothelial cells to cardiomyocytes, and vice versa, regulating microvascular properties and angiogenic processes in the heart. Small-exocytosed vesicles, called exosomes, which are secreted by both cell types, can mediate this intercellular communication. The purpose of this review is to highlight the contribution of the microvasculature to proper heart function maintenance by focusing on the interaction between cardiac endothelial cells and myocytes with a specific emphasis on non-coding RNAs (ncRNAs) in this form of cell-to-cell communication. Finally, the potential of ncRNAs as targets for angiogenesis therapy will also be discussed.

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Section: Angiogenic Ncrnas As Potential Therapeutic Targets For Heartmentioning

confidence: 99%