Nep formation, a drawback in the air-jet texturing process, can be controlled to some extent by suitable choices of certain factors related to the process. In order to understand how these variables influence nep formation in air-jet texturing, a central composite design is formulated and four variables—air pressure, texturing speed, mechanical stretch, and overfeed—are considered. Analysis of the results indicates that air pressure, texturing speed, and overfeed contribute significantly to nep formation, but mechanical stretch has little or no effect.