Nephro-Protective Effect of Wheat Germ Oil on Gentamicin-Induced Acute Nephrotoxicity in Wistar Albino Rat

Hafez, Lamiaa; Ali, Fatma Abo Zakaib; El-Ghoneimy, Ashraf A.; Abdel-Aziz, Magdy I.

doi:10.21608/svu.2019.23582

Cited by 2 publications

(2 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been reported that some symptoms of nephrotoxicity are present in up to 30 percent of patients treated with gentamicin for more than 7 days (3). Renal damage is often expressed by an increase in creatinine and urea nitrogen serum levels (4).…”

mentioning

confidence: 99%

Evaluation of the effect of administration of Tadalafil on Gentamicin-induced nephrotoxicity in rats

Mohammed¹,

Elberry²,

Sayed³

et al. 2022

Egyptian Journal of Medical Research

View full text Add to dashboard Cite

Background: Gentamicin (GNT) is a highly effective aminoglycoside antibiotic that is commonly used to treat life-threatening bacterial infections. Aim: The aim of the current study is to determine whether tadalafil can protect against GNT-induced nephrotoxicity. Methods: Twenty-four male Albino rats were used in the study, which were randomly divided into four groups, six animals each.Control untreated group received distilled water (5ml/kg, P.O) for 12 days and on days 6-12, they received (5ml/kg,i.p) normal saline daily, one hour after oral administration of distilled water.Tadalafil group received tadalafil (5mg/kg, P.O) for 12 days and on days 6-12, they received (5ml/kg,i.p) of normal saline daily, one hour after oral administration of tadalafil. Gentamicin group received distilled water (5ml/kg, P.O) and on days 6-12, they received gentamicin (011mg/kg,i.p) one hour after oral administration of distilled water. Gentamicin+Tadalafil group received tadalafil (5mg/kg, P.O) for 12 days and on days 6-12, they received gentamicin (100mg/kg,i.p) one hour after oral administration of tadalafil. Body weight and kidney weight were investigated. Urine volume as well as urinary albumin, creatinine, creatinine clearance and albumin /creatinine ratio (ACR) were evaluated. Besides, serum levels of urea and creatinine were measured as kidney function parameters.Renal tissues oxidative stress markers as malondialdehyde (MDA) and the antioxidant enzymes as superoxide dismutase (SOD) and catalase (CAT) activities. Renal cortex nitric oxide (NO) and kidney injury molecule-1 (KIM-1) were evaluated. Histological analysis and immunohistochemical expression of endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase (iNOS) were

show abstract

mentioning

confidence: 99%

Evaluation of the effect of administration of Tadalafil on Gentamicin-induced nephrotoxicity in rats

Mohammed¹,

Elberry²,

Sayed³

et al. 2022

Egyptian Journal of Medical Research

View full text Add to dashboard Cite

show abstract

“…The wheat germ oil is the richest natural source of vitamin E (α-tocopherol) (Gerald et al, 2017). Hafez et al (2019) found that rats received 3g/kg wheat germ oil had a non-significant increase in Malondialdehyde (MDA) levels of serum at the 15 th day of study as compared to control group. Saleh (2016) found that oral administration of wheat germ oil (1400 mg⁄kg) to mice for eight days improved the liver and small intestine damage induced by carbon tetrachloride.…”

Section: Introductionmentioning

confidence: 99%

Using of Untreated and Autoclave-Treated Wheat Germ Meal in Growing Rabbit Diets.

Salama¹,

Refaie²,

Amin³

et al. 2019

jwpr

View full text Add to dashboard Cite

The present study was intended to investigate the influence of using 20% and 40% treated or untreated wheat germ meal in growing New Zealand rabbit diets. A total of 75 weaned New Zealand White rabbits aged six weeks old, with an average initial weight of 659.60±18.84g were divided into five groups with five replicates in each group (three rabbits per replicate). The first group was fed on a basal diet (T 1 ), second and third groups received diets containing Wheat Germ Meal (WGM), as replacement of soybean meal protein, at levels of 20% and 40% and were labeled as T 2 , T 3 , respectively. Fourth and fifth groups were fed with 20% and 40% autoclave-treated WGM (T 4 and T 5 , respectively). The trial was continued until 14 weeks of age. The present study was evaluated growth performance, blood parameters, carcass traits, meat quality in different groups and also economic efficiency was calculated. There were insignificant differences in terms of live weight, daily weight gain, carcass weight and dressing percentages among rabbits in groups of T 1 , T 2 , and T 4 . Rabbits in the group of T 4 achieved the best feed conversion ratio. Digestion coefficients of crude protein, crude fiber, ether extract, nitrogen-free extract, and nutritive value in terms of digestible crude protein, total digestible nutrition, and digestible energy did not significantly differ between T 1 and T 4 . However, these factors significantly decreased in T3 and T 5 compared to T 1 . Plasma total protein and globulin significantly increased in rabbits of T 2 and T 4 compared to those fed in T 1 group. A significant decrease in total cholesterol and total lipid for rabbits in groups of T 4 , T 5, and T 2 was observed. Moreover, rabbits fed on T 4 or T 2 diets had the highest economic efficiency. Conclusively, the untreated or autoclaved WGM can be used in growing rabbit diets up to 20% for replacing the soybean meal protein, which caused low feed costs without adverse effects on the growth performance of rabbits.

show abstract

Nephro-Protective Effect of Wheat Germ Oil on Gentamicin-Induced Acute Nephrotoxicity in Wistar Albino Rat

Cited by 2 publications

References 3 publications

Evaluation of the effect of administration of Tadalafil on Gentamicin-induced nephrotoxicity in rats

Evaluation of the effect of administration of Tadalafil on Gentamicin-induced nephrotoxicity in rats

Using of Untreated and Autoclave-Treated Wheat Germ Meal in Growing Rabbit Diets.

Contact Info

Product

Resources

About