Nephrocalcinosis in primary Sjogren's syndrome

Gharbi, Chems; Rottembourg, Jacques; Izzedine, Hassane

doi:10.1093/ckj/sfu002

Cited by 3 publications

(5 citation statements)

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“…dRTA most typically is associated with Sjogren's syndrome occurs in as many as 33% of patients. [ 5 ]…”

Section: Discussionmentioning

confidence: 99%

“…pSS may present itself as dRTA-associated NC by autoantibodies directed against the A-type intercalated cells within the collecting tubules causing a defect in hydrogen-ion secretion. [ 5 ] The mechanism of hypokalemia in Sjogren's syndrome can be attributed to dRTA triggered by chronic interstitial nephritis which ends up in decreased tubular sodium delivery, defective H-K ATPase, secondary hyperaldosteronism, and bicarbonaturia. [ 6 ] Our patients described incase 1 had repeated episodes of hypokalemia and metabolic acidosis in the past, which responded symptomatically to potassium supplementation alone.…”

Section: Discussionmentioning

confidence: 99%

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Nephrocalcinosis—A gateway to the diagnosis

Atlani¹,

Rai²,

Kohat³

et al. 2021

Indian J Nephrol

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Nephrocalcinosis (NC) is the augmented calcium content within the renal parenchyma. Its pathogenesis mainly involves hypercalciuria. The presence of medullary NC provides a window to the clinician for the diagnosis of many important diseases. In this case series, we highlight three diseases that could be diagnosed with a high index of suspicion and detailed evaluation after their presentation as medullary NC.

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“…dRTA most typically is associated with Sjogren's syndrome occurs in as many as 33% of patients. [ 5 ]…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Nephrocalcinosis—A gateway to the diagnosis

Atlani¹,

Rai²,

Kohat³

et al. 2021

Indian J Nephrol

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“…Puede ser un hallazgo incidental o manifestarse por síntomas leves en la mayoría de los casos 8 . Sin embargo, se han reportado complicaciones más significativas como litiasis renal y nefrocalcinosis que derivan en deterioro de la función renal, y casos severos de parálisis hipocalémica 3,[10][11][12] . La afectación tubular crónica puede provocar diabetes insípida nefrogénica secundaria 4 .…”

Section: Discussionunclassified

“…Ante un paciente con SSp y alteraciones hidroelectrolíticas séricas y urinarias, debe sospecharse la posibilidad de NTI, y valorar su confirmación a través de biopsia renal 3 . Tanto la ATR tipo I como la tipo II pueden causar nefrocalcinosis debido a hipercalciuria y acidosis [10][11][12] . Este proceso suele ser identificable por radiografía de abdomen con una sensibilidad (S) de 63-66% 12 .…”

Section: Discussionunclassified

“…Tanto la ATR tipo I como la tipo II pueden causar nefrocalcinosis debido a hipercalciuria y acidosis [10][11][12] . Este proceso suele ser identificable por radiografía de abdomen con una sensibilidad (S) de 63-66% 12 . La ecografía (S 85-90%) también es un excelente método de detección temprana, y demostró ser superior a la TAC (S 81-86%) en el manejo clínico y la monitorización de los pacientes con nefrocalcinosis leve a moderada 13,14 .…”

Section: Discussionunclassified

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Nefrocalcinosis y acidosis tubular renal proximal en síndrome de Sjögren

Baenas

Balverdi

Retamozo

et al. 2018

Rev Fac Cien Med Univ Nac Cordoba

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El síndrome de Sjögren primario es una enfermedad autoinmune sistémica de evolución crónica. Puede presentar compromiso renal hasta en un 30% de los pacientes.La incidencia de tubulopatías varía de 2.6 a 33%. Se manifiestan por defectos en la concentración de la orina y alteraciones hidroelectrolíticas, principalmente acidosis tubular distal y de manera excepcional acidosis tubular proximal. Estos trastornos pueden asociarse a Nefrocalcinosis y litiasis renal. Reportamos el caso de una paciente con Sjögren primario que presentó acidosis tubular renal proximal asociada a cólicos renales recurrentes por litiasis renal y nefrocalcinosis. Destacamos la importancia de diagnosticar acidosis tubular renal en pacientes con síndrome de Sjögren que presenten alteraciones en el sedimento urinario y desórdenes electrolíticos para evitar la nefrocalcinosis medular y las nefrolitiasis asociadas. La terapia para la corrección de la acidosis tiene como objetivo evitar la progresión del trastorno y preservar la función renal.

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Recommendations for evaluation and diagnosis of extra-glandular manifestations of primary sjogren syndrome: results of an epidemiologic systematic review/meta-analysis and a consensus guideline from the Brazilian Society of Rheumatology (articular, pulmonary and renal)

et al. 2022

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Sjogren's Syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration of the exocrine glands and other organs, associated with sicca syndrome but also with systemic involvement with varying degrees of severity. Despite their importance, these systemic manifestations are not routinely evaluated and there is no homogenous approach to their diagnosis or evaluation. To close this gap, a panel of experts from the Brazilian Society of Rheumatology conducted a systematic review and meta-analysis on the identification of epidemiologic and clinical features of these manifestations and made recommendations based on the findings. Agreement between the experts was achieved using the Delphi method. The first part of this guideline summarizes the most important topics, and 11 recommendations are provided for the articular, pulmonary, and renal care of SS patients.

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Nephrocalcinosis in primary Sjogren's syndrome

Cited by 3 publications

References 0 publications

Nephrocalcinosis—A gateway to the diagnosis

Nephrocalcinosis—A gateway to the diagnosis

Nefrocalcinosis y acidosis tubular renal proximal en síndrome de Sjögren

Recommendations for evaluation and diagnosis of extra-glandular manifestations of primary sjogren syndrome: results of an epidemiologic systematic review/meta-analysis and a consensus guideline from the Brazilian Society of Rheumatology (articular, pulmonary and renal)

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