Nephrogenic Diabetes Insipidus and Obstructive Uropathy

Congenital nephrogenic diabetes insipidus in a baby girl.

“…NDI is generally associated with otherwise normal renal function. Although our patient has developed hydronephrosis, this is a known complication of NDI (Wiggelinkhuizen et al, 1973). The hydronephrosis is thought to arise from a functional obstruction due to a large flow of urine relative to the size of the collecting system, and may be severe enough to produce renal damage necessitating urinary diversion procedures.…”

“…It is probable that many of these were carriers. There are few well documented recent reports of women with the full expression of this disorder (Wiggelinkhuizen et al, 1973;Zimmerman and Green, 1975). NDI is generally associated with otherwise normal renal function.…”

Nonobstructive urinary tract dilatation in children with diabetes insipidus

“…By this time, urinary tract changes were advanced, and our worry was that prolonged backpressure almost certainly would have resulted in further renal damage. The cause of progressive bladder distension probably results from a functional impairment at the level of the bladder neck because of detrusor hypertrophy, while intermittent obstruction at the intravesical portion of the ureter is the likely cause of upper tract dilatation [10]. As the child grows, the natural voluntary retention that develops likely exacerbates and accelerates the dilatation seen in this patient group.…”

Nephrogenic diabetes insipidus: a cause of severe nonobstructive urinary tract dilatation.

“…This likely exacerbates the progressive dilatation of the urinary tract. 7 Initial radiographic evaluation of bilateral "hydronephrosis" should be thorough in the hope of discovering potentially correctable causative conditions. Ultrasonograph}" voiding cystourethrography, and reflux studies are all important modalities that should be considered.…”