Nephrographic Effect in Renal Angiography; An Experimental Study in Dogs

Non-ultrafiltrable contrast medium for renal angiography

“…It would seem reasonable to assume that the rate of renal elimination of the contrast media used may be of essential importance, but although the rapid elimination of current angiographic media is recognized its possible relevance to the present problem has apparently escaped attention. The existence of such a connexion is, however, suggested by an experiment on record, in which bilateral renal angiography was performed in a dog with simultaneous injection of Miokon into one renal artery and Thorotrast into the other (EDLING & HELANDER 1959). The angiograms were compared to analyze the nephrographic effect of the contrast media used and the conclusions drawn were confined to this Submitted for publication 5 September 1961. matter, but the differences observed included better demonstration of the renal veins by Thorotrast.…”

Nephrotomography:A Simplified Technique and Results

“…Because of this, and also from observations made during renal arteriography, a distinction was made between the arterial nephrogram and the tubular nephrogram, refemng to the presence of contrast in the renal arterioles and tubules respectively. Edling and Helander (1959) injected the renal arteries of dogs with thorium dioxide on one side (a substance not excreted by the kidney) and diacetrizoate on the other. The density of the parenchyma of both kidneys increased up to 34 seconds; thereafter the thoriuminjected kidney decreased, but the other kidney continued to increase in density for some 27 seconds and then diminished.…”