Nephrolithiasis: Endocrine evaluation

Ranabir, Salam; Baruah, Manash P; Devi, Keisam Reetu

doi:10.4103/2230-8210.93740

Cited by 9 publications

(5 citation statements)

References 93 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Assessment of risk factors for stone disease should be carried out [20] . Medical management of stone disease includes laboratory evaluation and treatment [22] . Medical treatments of kidney stones includes dietary management, disease-specific therapies, and medical expulsion therapy (MET) of stones [23] .…”

Section: Management Of Renal Calculimentioning

confidence: 99%

Renal calculi and unani medicine: A review

Siddiqui¹,

Haq²,

Nawaz³

2019

Int. J. Unani. Integ. Med.

View full text Add to dashboard Cite

Kidney stone disease is a crystal concretion formed usually within the kidneys. It is an increasing urological disorder of human health, affecting about 12% of the world population. Ancient Unani Literature is enriched in Hasaat-e-Kulya (Renal Stone), where as Unani physician described broadly the pathology, manifestation and treatment. In Unani system of medicine the drug used for renal calculus breaks the stone and then remove it groom urinary system.Pharmacologically it will be treated with single or either compound drugs such as

show abstract

Section: Management Of Renal Calculimentioning

confidence: 99%

Renal calculi and unani medicine: A review

Siddiqui¹,

Haq²,

Nawaz³

2019

Int. J. Unani. Integ. Med.

View full text Add to dashboard Cite

show abstract

“…The appearance of nephrolithiasis, as well as its severity, may be the result of numerous endocrine disorders. The endocrinopathies leading to urolithiasis are ones resulting in hypercalcemia or disrupted excretion of urine calcium or phosphates [ 26 , 27 ]. The most common endocrine cause of hypercalcemia is primary hyperparathyroidism.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Nephrolithiasis Treatment in Highest Reference Hospital—Occurrence of Acromegaly in the Study Group

Ząbkowski

Durma²,

Grabińska

et al. 2023

JCM

View full text Add to dashboard Cite

Background: Urolithiasis is one of the most common diseases of the urinary system, the incidence of which is assumed to be up to 100,000 cases per million (10% of the population). The cause of it is dysregulation of renal urine excretion. Acromegaly is a very rare endocrine disorder that causes a somatotropic pituitary adenoma producing higher amounts of growth hormone. It occurs approximately in 80 cases per million (about 0.008% of the population). One of the acromegaly complications may be urolithiasis. Methods: Clinical and laboratory results of 2289 patients hospitalized for nephrolithiasis in the highest reference hospital were retrospectively analyzed, distinguishing a subgroup of patients with acromegaly. Statistical analysis was performed to compare the prevalence of the disease in the analyzed subgroup with the epidemiological results available in up-to-date literature. Results: The distribution of nephrolithiasis treatment was definitely in favor of non-invasive and minimally invasive treatment. The methods used were as follows: ESWL (61.82%), USRL (30.62%), RIRS (4.15%), PCNL (3.1%), and pyelolithotomy (0.31%). Such a distribution limited the potential complications of the procedures while maintaining the high effectiveness of the treatment. Among two thousand two hundred and eighty-nine patients with urolithiasis, two were diagnosed with acromegaly before the nephrological and urological treatment, and seven were diagnosed de novo. Patients with acromegaly required a higher percentage of open surgeries (including nephrectomy) and also had a higher rate of kidney stones recurrence. The concentration of IGF-1 in patients with newly diagnosed acromegaly was similar to those treated with somatostatin analogs (SSA) due to incomplete transsphenoidal pituitary surgery. Conclusions: In the population of patients with urolithiasis requiring hospitalization and interventional treatment compared to the general population, the prevalence of acromegaly was almost 50-fold higher (p = 0.025). Acromegaly itself increases the risk of urolithiasis.

show abstract

“…Although all the underlying causes behind the formation of kidney stones are not fully known, the literature suggests genetics as a crucial factor in susceptibility to some types of nephrolithiasis (4,19) along with environmental and dietary factors (40,43). There are two main models describing the role of genetics in kidney stone formation: the monogenic codominant model (26), in which a single gene actively accelerates stone accumulation (24), and the polygenic or heterogeneous coinheritance model (52,63), in which two or more genes act coherently to each other to accelerate or inhibit stone accumulation (25,51). Thus, basic research to determine the role of genes in stone formation with new animal models to investigate the pathophysiology of the disease may play a vital role in the advancement of the field, leading to new therapeutic agents for the management of kidney disease (36).…”

Section: Introductionmentioning

confidence: 99%

Targeted renal knockdown of Na⁺/H⁺exchanger regulatory factorSip1produces uric acid nephrolithiasis inDrosophila

Ghimire

Terhzaz

Cabrero

et al. 2019

American Journal of Physiology-Renal Physiology

View full text Add to dashboard Cite

Nephrolithiasis is one of the most common kidney diseases, with poorly understood pathophysiology, but experimental study has been hindered by lack of experimentally tractable models. Drosophila melanogaster is a useful model organism for renal diseases because of genetic and functional similarities of Malpighian (renal) tubules with the human kidney. Here, we demonstrated function of the sex-determining region Y protein-interacting protein-1 ( Sip1) gene, an ortholog of human Na+/H+ exchanger regulatory factor ( NHERF1), in Drosophila Malpighian tubules and its impact on nephrolithiasis. Abundant birefringent calculi were observed in Sip1 mutant flies, and the phenotype was also observed in renal stellate cell-specific RNA interference Sip1 knockdown in otherwise normal flies, confirming a renal etiology. This phenotype was abolished in rosy mutant flies (which model human xanthinuria) and by the xanthine oxidase inhibitor allopurinol, suggesting that the calculi were of uric acid. This was confirmed by direct biochemical assay for urate. Stones rapidly dissolved when the tubule was bathed in alkaline media, suggesting that Sip1 knockdown was acidifying the tubule. SIP1 was shown to collocate with Na+/H+ exchanger isoform 2 (NHE2) and with moesin in stellate cells. Knockdown of NHE2 specifically to the stellate cells also increased renal uric acid stone formation, and so a model was developed in which SIP1 normally regulates NHE2 activity and luminal pH, ultimately leading to uric acid stone formation. Drosophila renal tubules may thus offer a useful model for urate nephrolithiasis.

show abstract

Nephrolithiasis: Endocrine evaluation

Cited by 9 publications

References 93 publications

Renal calculi and unani medicine: A review

Renal calculi and unani medicine: A review

Analysis of Nephrolithiasis Treatment in Highest Reference Hospital—Occurrence of Acromegaly in the Study Group

Targeted renal knockdown of Na⁺/H⁺exchanger regulatory factorSip1produces uric acid nephrolithiasis inDrosophila

Contact Info

Product

Resources

About

Nephrolithiasis: Endocrine evaluation

Cited by 9 publications

References 93 publications

Renal calculi and unani medicine: A review

Renal calculi and unani medicine: A review

Analysis of Nephrolithiasis Treatment in Highest Reference Hospital—Occurrence of Acromegaly in the Study Group

Targeted renal knockdown of Na+/H+exchanger regulatory factorSip1produces uric acid nephrolithiasis inDrosophila

Contact Info

Product

Resources

About

Targeted renal knockdown of Na⁺/H⁺exchanger regulatory factorSip1produces uric acid nephrolithiasis inDrosophila