Nephrolithiasis in inflammatory bowel disease

Gelzayd, Eugene A.; Breuer, Richard I.; Kirsner, Joseph B.

doi:10.1007/bf02233547

Cited by 137 publications

(27 citation statements)

References 32 publications

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“…Hyperoxaluria is generally accepted as the main pathogenic factor. Patients with Crohn's disease have been demonstrated to be at a higher risk for kidney stone formation; however, the pathogenesis is still under debate [6], while the theory of hyperoxaluria is very much favored. Six of the 86 (7%) studied patients No relationship between kidney stone formation and previous operations could be found, as had been suggested by Andersson et al [I].…”

Section: Discussionmentioning

confidence: 98%

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Urinary factors of kidney stone formation in patients with Crohn's disease

et al. 1988

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An increased frequency of kidney stone formation is reported in patients with inflammatory bowel disease. In order to investigate its pathogenesis, the concentrations of factors known to enhance calcium oxalate stone formation (oxalate, calcium, uric acid) as well as of inhibitory factors for nephrolithiasis (magnesium, citrate) were determined in the urine of 86 patients with Crohn's disease and compared with those of 53 metabolically healthy controls. Six patients with Crohn's disease already had experienced calcium oxalate nephrolithiasis. Patients with Crohn's disease had significantly higher urinary oxalate and lower magnesium and citrate concentrations. Among all patients magnesium and citrate were significantly lower in those with a positive history of kidney stones. Our results demonstrate that the increased propensity for renal stone formation in patients with Crohn's disease is a result not only of increased urinary oxalate, but also of decreased urinary magnesium and citrate concentrations.

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Section: Discussionmentioning

confidence: 98%

“…Although in a large survey of patients with inflammatory bowel disease renal calculi are reported in 7.2% of the cases [6], prevalence and possible * Dedicated to Professor Dr. N. Z611ner on the occasion of his 65th birthday Abbreviations: CDA! = Crohn's disease activity index pathogenic factors are still controversial issues [10,12,13,25].…”

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confidence: 99%

Urinary factors of kidney stone formation in patients with Crohn's disease

et al. 1988

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“…The chemical characterization of the ureteral calculi in inflammatory bowel disease is unclear, although evidence shows an increased incidence of calcium oxalate stones [2,4]. Several etiological factors have been suggested for nephrolithiasis in these patients: increased concentration on excretion of urinary crystalloids, possibly related to the administration of adrenal cortical steroids; persistent excretion of an acid urine; and, in some cases, oliguria due to intestinal surgery.…”

Section: Discussionmentioning

confidence: 97%

Urological complications of regional enteritis

Kruglik

Neiman

Sparberg

et al. 1976

Gastrointest Radiol

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Abstract. Urological complications of regional enteritis occur frequently and may be clinically unsuspected. Radiographic findings include nephrolithiasis, characteristic stricture of the ureter, panvesiculitis, and enterovesical fistula. Less specific findings include renal amyloidosis and retroperitoneal abscesses. Mucosal nodularity of the bladder dome, even without gastrointestinal symptoms, should raise the possibility of regional enteritis. On the other hand, occult ureteral stenosis in patients with known regional enteritis may be present. For this reason, it is recommended that routine and periodic excretory urograms be a central part of the evaluation of the patient with regional enteritis.

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“…Inflammatory disease or extensive resection of small bowel may increase colon oxalate absorption and cause hyperoxaluria with nephrolithiasis (1)(2)(3)(4)(5)(6)(7). Excessive amounts of bile salts and fatty acids that reach the colon in these diseases could enhance oxalate absorption by specifically increasing oxalate permeability (8) or by altering the charge and size selectivity of the epithelium in general.…”

Section: Introductionmentioning

confidence: 99%

Evidence for size and charge permselectivity of rat ascending colon. Effects of ricinoleate and bile salts on oxalic acid and neutral sugar transport.

Kathpalia¹,

Favus²,

Coe³

1984

J. Clin. Invest.

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A bbstract. We have measured unidirectional transmural fluxes of oxalate and neutral sugars across rat ascending colon in vitro, under short-circuit conditions, to characterize permeability barriers selective for size and charge. Ionic oxalate appears to be transported preferentially to sodium oxalate. Mucosal addition of taurocholate (1 mM), deoxycholate (1 mM), or ricinoleate (1 mM) increased bidirectional oxalate fluxes, and the ricinoleate effects were independent of medium calcium. Bidirectional fluxes of uncharged sugar molecules fell sharply at molecular weights above 76 (molecular radius above 3 A), and oxalate transport was retarded relative to that of uncharged molecules of similar size, suggesting that there is both size and charge permselectivity. Ricinoleate increased fluxes of all neutral molecules tested but changed neither the exclusion limits nor the cation selectivity of the epithelium. Bile salts and ricinoleate increase oxalate transport, probably by making more channels available, but do not alter size and charge selectivity.

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Nephrolithiasis in inflammatory bowel disease

Cited by 137 publications

References 32 publications

Urinary factors of kidney stone formation in patients with Crohn's disease

Urinary factors of kidney stone formation in patients with Crohn's disease

Urological complications of regional enteritis

Evidence for size and charge permselectivity of rat ascending colon. Effects of ricinoleate and bile salts on oxalic acid and neutral sugar transport.

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