Néphropathie lupique : quelle fréquence ? Quelle forme histologique ? Et quels facteurs prédictifs de l’atteinte rénale ?

En-Nasri, S.; Fouad, Z.; Fadili, W.; Essaadouni, L.; Laouad, I.

doi:10.1016/j.nephro.2011.07.231

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“…Lupus nephritis can manifest itself with different clinical spectrums such as proteinuria, haematuria, anormal urine sediment, and renal failure. Histological examination of the kidney is essential in the diagnosis and grading of lupus nephritis due to the variety of clinical findings 6 . We aimed to investigate the value role of 2019 EULAR/ACR classification criteria in predicting the biopsy-proven LN among children with SLE.…”

Section: Introductionmentioning

confidence: 99%

The value of 2019 EULAR/ACR classification criteria in predicting lupus nephritis in childhood-onset systemic lupus erythematosus

et al. 2023

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Background We investigated the role of European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) classification criteria for the prediction of LN among children with SLE. Methods The data of the patients with childhood-onset SLE diagnosed based on 2012 Systemic Lupus International Collaborating Clinics (SLICC) criteria were retrospectively evaluated. Based on 2019 EULAR/ACR classification criteria, the scoring was done at the time of renal biopsy. Results Fifty-two patients (12 with LN, 40 without LN) were included. The mean score was higher in patients with LN than those without (30.8±6.14, 19.8±7.76, respectively, p=0.000). The score value had indicative value for LN (area under curve [AUC]:0.863±0.055, cut-off value:22.5, p=0.000). Lymphocyte counts had a predictive value for LN (cut-off value:905/mm3, AUC:0.688±0.087, p=0.042). The score was positively associated with SLE disease activity index (SLEDAI) and activity index (r=0.879, p=0.000; r=0.811, p=0.001, respectively). There were significant negative associations between score value and GFR (r=-0.582, p=0.047). The patients with renal flare had higher the mean score than those of without renal flare (35±2/25.4±5.57, respectively, p=0.019). Conclusions The EULAR/ACR criteria score could reflect the activity of disease and severity of nephritis in childhood-onset SLE. A point of 22.5 as score value might be an indicator for LN. During scoring, it should be taken into account that lymphopenia might guide the prediction of LN.

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Section: Introductionmentioning

confidence: 99%