Nephroprotective activity of Alyssum meniocoides Boiss aqueous extract on streptozotocin-induced diabetic nephrotoxicity in male mice

Zangeneh, Mohammad Mahdi; Zangeneh, Akram; Amiri, Hossein; Amiri, Nassim; Tahvilian, Reza; Moradi, Rohallah; Zhaleh, Hossein; Tehrani, Payam Razeghi

doi:10.1007/s00580-018-2712-7

Cited by 11 publications

(4 citation statements)

References 23 publications

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“…This was also evidenced by histopathology studies of renal tissues. The decrease in the congestion in glomerulus, intratubular hemorrhage, and protection from damage shown by reduced tissue/cellular damage to the cells of nephron was seen in animals treated with CEAP when compared to that in disease control group animals, where there is damage to nephrons was observed in those animals when compared to that in the positive control group 11 .…”

Section: Fig 1: Graph Representing Serum Creatininementioning

confidence: 83%

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2021

IJPSR

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Section: Fig 1: Graph Representing Serum Creatininementioning

confidence: 83%

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2021

IJPSR

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“…Previous studies showed that most medicinal plants are rich in anti-inflammatory compounds and antioxidants wherein the plants nephroprotective effects could be related to these compounds [ 8 , 10 , 51 ]. The nephroprotective effect of CN in the present study could be related to the presence of anti-inflammatory properties and antioxidant.…”

Section: Discussionmentioning

confidence: 99%

“…Among the medicinal plants that are consumed for their nephroprotective effects included Rubia cordifolia Linn. (root), Boerhaavia diffusa (root), Aerva javanica (fresh roots), Curcuma longa (rhizome), Ficus religiosa L. (latex), Tectona grandis (bark), Strychnos potatorum (seed), Carica papaya (seed), Crataeva nurvala (fruit), Tamarindus indica (fruit pulp), Punica granatum L. (fruit peel), Euphorbia neriifolia (leaf), Vernonia cinerea (aerial part), Acorus calamus (aerial part), Aerva lanata (whole plant), and Orthosiphon stamineus (whole plant) [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

NMR and LCMS analytical platforms exhibited the nephroprotective effect of Clinacanthus nutans in cisplatin-induced nephrotoxicity in the in vitro condition

Mahmod

Ismail

Alitheen

et al. 2020

BMC Complement Med Ther

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Background Clinacanthus nutans (C. nutans) Lind. locally known as Belalai Gajah or Sabah snake grass is a medicinal plant belonging to Acanthaceae family. In Asia, this plant is traditionally used for treating skin rashes, insects and snake bites, diabetes mellitus, fever and for diuretic effect. C. nutans has been reported to possess biological activities including anti-oxidant, anti-inflammation, anti-cancer, anti-diabetic and anti-viral activities. Methods Proton Nuclear Magnetic Resonance (1H NMR) and Liquid Chromatography Mass Spectroscopy (LCMS) coupled with multivariate data analysis were employed to characterize the metabolic variations of intracellular metabolites and the compositional changes of the corresponding culture media in rat renal proximal tubular cells (NRK-52E). Results NMR and LCMS analysis highlighted choline, creatine, phosphocholine, valine, acetic acid, phenylalanine, leucine, glutamic acid, threonine, uridine and proline as the main metabolites which differentiated the cisplatin-induced group of NRK-52E from control cells extract. The corresponding media exhibited lactic acid, glutamine, glutamic acid and glucose-1-phosphate as the varied metabolites. The altered pathways perturbed by cisplatin nephrotoxic on NRK-52E cells included changes in amino acid metabolism, lipid metabolism and glycolysis. Conclusion The C. nutans aqueous extract (1000 μg/mL) exhibited the most potential nephroprotective effect against cisplatin toxicity on NRK-52E cell lines at 89% of viability. The protective effect could be seen through the changes of the metabolites such as choline, alanine and valine in the C. nutans pre-treated samples with those of the cisplatin-induced group.

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“… 7 , 8 Reports on the reno-hepatic and antidiabetic properties of medicinal plants have been recorded by analyzing biochemical and histological parameters of the kidney, liver and pancreas. 9 , 10 Studies have suggested medicinal plants can be useful in controlling blood glucose level, 11 improve renal biomarkers and restore hepatic functions. 12 Previous studies have indicated that plants play major roles in ameliorating toxicities induced by arsenic.…”

Section: Introductionmentioning

confidence: 99%

Reno-Hepatoprotective and Antidiabetic Properties of Methanol Leaf Extract of Laportea Aestuans in Wistar Rats

Adetunji

Olugbami

Adegoke

et al. 2021

J Evid Based Complementary Altern Med

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Toxicities due to exposure to arsenic-contaminated water and the occurrence of diabetes mellitus are major health concerns. Treatment of these concerns using therapeutic measures have recorded limited success. Traditionally, Laportea aestuans (LA) has been used in managing various diseases. Hence, we investigated the reno-hepatoprotective/antidiabetic potentials of methanol leaf extract of LA (MeLELA) in male Wistar rats. Thirty rats (100-150 g) were equally distributed into 6 groups: Group I (vehicle-treated); group II received 2.5 mg/kg sodium arsenite (SA) thrice a week for 2 weeks; group III received streptozotocin (STZ, 50 mg/kg once); group IV received 200 mg/kg LA daily for 14 days; group V received SA and LA; group VI received STZ and LA. Sodium arsenite and STZ induced reno-hepatotoxicity and diabetes, respectively. Phytochemical screening, biomarkers/enzyme activities, blood glucose levels, micronucleus assay, kidney, liver and pancreas histologies were determined according to standard procedures. Alkaloids, carotenoids and flavonoids were present in abundance. Both SA-and STZ-treated groups recorded significant (p < 0.05) reductions in serum protein concentrations, while co-treatment with LA significantly restored the levels. The SA-induced significant increase in creatinine/urea levels were significantly reduced by LA. Co-treatment of each of SA-and STZ-treated groups, respectively, with LA significantly decreased the elevated serum alanine and aspartate aminotransferases’ activities. Increased blood glucose level in diabetic group was remarkably lowered by LA. Also, the SA-induced frequency of micronucleated polychromatic erythrocytes was significantly ameliorated by LA. Conclusively, LA is protective against SA-induced toxicity and STZ-induced diabetes in Wistar rats.

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Nephroprotective activity of Alyssum meniocoides Boiss aqueous extract on streptozotocin-induced diabetic nephrotoxicity in male mice

Cited by 11 publications

References 23 publications

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NMR and LCMS analytical platforms exhibited the nephroprotective effect of Clinacanthus nutans in cisplatin-induced nephrotoxicity in the in vitro condition

Reno-Hepatoprotective and Antidiabetic Properties of Methanol Leaf Extract of Laportea Aestuans in Wistar Rats

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