Nephroprotective Effect of Costus (Saussurea costus) Ethanolic Extract on Oxaliplatin®-induced Nephrotoxicity in Adult Male Wistar Rats

Ashry, Mahmoud; El-Sahra, Doaa Galal; Gaber, Dalia A; Mustafa, M. A.; Abdel-Wahhab, Khaled G.

doi:10.3923/pjbs.2021.830.839

Cited by 6 publications

(3 citation statements)

References 33 publications

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“…Here, twenty-seven plants with renal proficiency viz., Sida rhombifolia (10), Apium leptophyllum (11), Aconitum heterophyllum (12), Abies webbiana (13), Artocarpus hirsutus (14), Paederia foetida (15), Cocculus pendulus (16), Alangium salvifolium (17), Ruta graveolens (18), Calophyllum inophyllum (19), Rubia cordifolia (20), Myrtus communis (21), Pongamia pinnata (22), Convallaria majalis (23), Saussurea costus (24), Mimusops elengi (25), Calendula officinalis (26), Ficus bengalensis (27), Hypericum mysorense (28), Toona sinensis (29), Nelumbo nucifera (30), Chelidonium majus (31), Eclipta alba (32), Alstonia scholaris (33), Pterocarpus marsupium (34), Centella asiatica (35), and Plumbago zeylanica (36) have been chosen to screen their inhibitory binding efficacy with the efflux transporter by molecular docking. This study will help in the identification of reno-protective natural compounds as p-glycoprotein inhibitors, which in addition possess the ability to enhance the absorption of renal treatment substrate drugs inside the efflux-prone target cell.…”

Section: Introductionmentioning

confidence: 99%

Co-administration of herbal inhibitors of P-glycoprotein with renal drugs enhance their bioavailability– In silico approach

Roy

Ghosh

2023

J Herbmed Pharmacol

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Introduction: Multidrug resistance (MDR) is primarily associated with reduced intracellular drug accumulation owing to overexpression of p-glycoprotein, an active efflux transporter. Competitive inhibition or allosteric modulation of p-glycoprotein may alter the pharmacokinetics of the drugs that serve as substrates, resulting in enhanced drug bioavailability and tissue penetration. This study endeavors to assess the efficacy of the components of reno-protective herbs in the inhibition of p-glycoprotein activity thereby enhancing the possibility of the retention of co-administered renal medications inside the target cells. Methods: Drug-likeness and pharmacokinetic properties were determined to ensure the safety and efficacy of herbal constituents. Molecular docking employing the CDOCKER module of Discovery Studio was performed to investigate the binding affinity between the active constituents and the p-glycoprotein receptor (6C0V). Molecular dynamics simulation was utilized to further assess the stability of the complex of receptors with the component bearing its maximal affinity. Results: The analyses suggested that the inhibitors viz., atisine, kutkin, and embelin from Aconitum heterophyllum, phylloquinone from Calendula officinalis, stigmasterol from Paederia foetida, and convallamarogenin from Convallaria majalis demonstrated maximum binding affinity towards p-glycoprotein. Conclusion: Atisine may thus be identified as the lead compound in the augmentation of drug bioavailability inside the cell, along with its reno-protective efficacy.

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Section: Introductionmentioning

confidence: 99%

Co-administration of herbal inhibitors of P-glycoprotein with renal drugs enhance their bioavailability– In silico approach

Roy

Ghosh

2023

J Herbmed Pharmacol

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“…[6] OXL has been associated with a variety of toxicities, including hepatotoxicity, nephrotoxicity, neurotoxicity, and others. [7][8][9] OXL-induced toxicity occurs in ~60%-80% of treated patients, with 15% suffering serious toxicity. [10] The liver is extremely sensitive to drug toxicity, as it plays a crucial role in the metabolism of numerous medications and toxins.…”

Section: Introductionmentioning

confidence: 99%

“…[ 6 ] Similarly, the condition of oxidative stress that develops in the renal tissue may be underlined as a severe adverse effect of OXL. [ 8 ] OXL is mainly excreted by the kidneys, with approximately half the total dose excreted in the urine by Day 5 after administration. Dose reductions are recommended in patients with CrCl <20 mL/min but is generally not required in patients with CrCl above this threshold.…”

Section: Introductionmentioning

confidence: 99%

Naringin attenuates oxaliplatin‐induced nephrotoxicity and hepatotoxicity: A molecular, biochemical, and histopathological approach in a rat model

Ileriturk,

Kandemir

et al. 2023

J Biochem & Molecular Tox

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Oxaliplatin (OXL) is a significant therapy agent for the worldwide increase in cancer cases. Naringin (4′,5,7‐trihydroxy flavonon 7‐rhamnoglucoside, NRG) has a wide range of biological and pharmacological activities, including antioxidant and anti‐inflammatory potentials. This research aimed to investigate NRG activity in OXL‐induced hepatorenal toxicity. Accordingly, OXL (4 mg/kg b.w.) in 5% glucose was injected intraperitoneally on the first, second, fifth, and sixth days, and NRG (50 and 100 mg/kg b.w.) was given orally 30 min before to treatment. Biochemical, genetic, and histological methods were utilized to investigate the function tests, oxidant/antioxidant status, inflammation, apoptosis, and endoplasmic reticulum (ER) stress pathways in kidney and liver tissues. Administration of NRG demonstrated an antioxidant effect by increasing the activities of OXL‐induced reduced antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) and decreasing the elevated lipid peroxidation parameter malondialdehyde levels. Nuclear factor‐κB, tumor necrosis factor‐α, interleukin‐1β, and inducible nitric oxide synthase levels increased in OXL administered groups but reduced in NRG‐treated groups. In the OXL‐administered groups, NRG reduced the apoptosis‐inducing factors Caspase‐3 and B‐cell lymphoma 2 (Bcl‐2)‐associated X protein levels, while elevating the antiapoptotic factor Bcl‐2 levels. OXL triggered prolonged ER stress by increasing the levels of ER stress parameters activating transcription factor 6, protein kinase R‐like ER kinase, inositol‐requiring enzyme 1α, and glucose‐regulated protein 78. Therefore, with the NRG administration, this activity was reduced and the ER stress level decreased. Taken together, it was found that OXL induced toxicity by increasing the levels of urea and creatinine, alanine transaminase, aspartate aminotransferase, and alkaline phosphatase activities, inflammation, apoptosis, ER stress, and oxidants in the liver and kidney tissue, and NRG had a protective effect by reversing the deterioration in these pathways.

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Therapeutic efficacy of Nano-formulation of lactoperoxidase and lactoferrin via promoting immunomodulatory and apoptotic effects

Fakharany

Ashry

Abd-Elaleem

et al. 2022

International Journal of Biological Macromolecules

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Nephroprotective Effect of Costus (Saussurea costus) Ethanolic Extract on Oxaliplatin®-induced Nephrotoxicity in Adult Male Wistar Rats

Cited by 6 publications

References 33 publications

Co-administration of herbal inhibitors of P-glycoprotein with renal drugs enhance their bioavailability– In silico approach

Co-administration of herbal inhibitors of P-glycoprotein with renal drugs enhance their bioavailability– In silico approach

Naringin attenuates oxaliplatin‐induced nephrotoxicity and hepatotoxicity: A molecular, biochemical, and histopathological approach in a rat model

Therapeutic efficacy of Nano-formulation of lactoperoxidase and lactoferrin via promoting immunomodulatory and apoptotic effects

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