Nephroprotective Effects of Carvedilol and Curcuma longa against Cisplatin-Induced Nephrotoxicity in Rats

Abstract

Objective: Goal of this study is to investigate the effects of carvedilol (5 mg/kg, p.o), aqueous and methanolic extract of Curcuma longa (500mg/kg, p.o) against cisplatin induced renal damage in Wistar rats after a single intraperitoneal injection of 7.5mg -1 . Methods: Wistar rats were randomly divided into 7 groups (n=10). Rats in group I were normal control received normal saline (5 ml/kg; i. p.) on day zero, while group VIa and VIb were vehicle control, received carboxymethyl cellulose (2.5 ml/kg; p.o.) and propylene glycole (2.5 ml/kg, p.o.) respectively from day 3 to 17. Renal toxicity was induced in rats of group II, III, IV and V by a single administration of cisplatin (7.5 mg/kg; i. p.) on day zero. Rats in group III, IV and V received a daily dose of carvedilol (5 mg/kg; p.o.), aqueous and methanolic extracts of Curcuma longa (500 mg/kg; p.o.) respectively from day 3 to 17, while group II served as cisplatin control.Results: Post treated rats with carvedilol and aqueous and methanolic extracts of Curcuma longa for 15 days significantly increased body weight, decreased cisplatin induced abnormalities and mortality and decreased all the kidney marker such as serum urea nitrogen (SUN), serum creatinine (SCr), total proteins (TP), and uric acid (UA) increased by cisplatin, however, no appreciable improvement in hematological parameters were observed when compared with cisplatin control. Conclusion:The results are indicative of nephroprotective effects of carvedilol as well as aqueous and methanolic extracts of Curcuma longa.

Protective effect of carvedilol alone and coadministered with diltiazem and prednisolone on doxorubicin and 5‐fluorouracil‐induced hepatotoxicity and nephrotoxicity in rats

“…In this study, carvedilol administered in the presence of doxorubicin and 5‐FU significantly decreased creatinine level compared with administration of the toxicants alone. This is a pointer to the nephroprotective effect of carvedilol, an observation supported by the findings of Wong et al and Pathak et al . Coadministration of carvedilol and diltiazem in the presence of the 2 toxicants resulted in a significant decrease in creatinine level compared with administration of the toxicants alone.…”

Oral administration of powdered dried rhizomes of Curcuma longa L. (turmeric, Zingiberaceae) is effective in the treatment of doxorubicin‐induced kidney injury in rats

“…In addition, the plant exhibits protective effects in animal models of myocardial (Tanwar, Sachdeva, Golechha, Kumari, & Arya, ; Yang, Wu, Li, & You, ), pulmonary (K. Liu et al, ; Sakurai et al, ), and renal injury (Mohamad et al, ; Sharma, Kulkarni, & Chopra, ). In rats, C. longa attenuated nephrotoxicity of gentamicin and cisplatin (Elgazar & AboRaya, ; Pathak, Rajurkar, Tarekh, & Badgire, ) and also protected the heart, liver, and kidneys from DOX‐induced toxicity (Mohamad et al, ). Curcumin also protected the kidneys against cadmium‐induced nephrotoxicity (K. S. Kim et al, ), ischemia–reperfusion injury (F. Liu et al, ), and, in the form of nanoparticles, against rhabdomyolysis‐induced kidney injury (Chen et al, ).…”

Ayurvedic Approach of Nephrotic Syndrome and its Management with Herbal and Herbomineral Preparations

“…Varuna (Crataeva nurvala): Some research works shows that Crataeva nurvala's alcoholic extract given in doses of 250 and 500 mg/kg for 10 days, it demonstrated protective effect against cisplatin's 5 mg/kg-induced nephrotoxicity. The findings indicated that the alcoholic extract considerably changed the dysfunction of renal proximal tubule cells by lowering blood urea nitrogen, creatinine, lipid peroxidation, glutathione, and catalase concentrations [33].…”