Nephrosclerosis postpartum and in women taking oral contraceptives

<i>Post partum </i>Haemolytic-Uraemic Syndrome Treated with Antithrombin-III

“…In our patient, kidney function began to fail shortly before labour. A similar syndrome is reported to occur in some women using oral contraceptives [10,11],…”

Hemolytic-Uremic Syndrome

“…It is commonly associated with intravascular coagulation and may, in part, be a pathogenetic factor in the renal failure. While it is conjectural whether these patients re present examples of HUS, a separate group of women were described about 10 years ago in whom the clinical picture of H US developed days to weeks following a normal or nearly uneventful pregnancy [4,28], Since then, numer ous cases have been reported [29][30][31][32][33], A similar clinicopathological picture has been reported in a number of women taking oral contraceptives [34][35][36][37],…”

“…In many of these cases, hypertension, often severe, is found at the time of presenta tion [34,35]. These cases bear a striking similarity to those in which malignant hypertension, uremia and microangio pathic hemolytic anemia have been found [57,58].…”

“…The clinical and histologic picture of the HUS following the use of oral contraceptives is virtually indistinguishable from that seen in the post-partum female [34], It may occur after the use of these agents for as short a time as I year or as long a period as 10 years [36]. In many of these cases, hypertension, often severe, is found at the time of presenta tion [34,35].…”

Die Klinik des h�molytisch-ur�mischen Syndroms

“…Bei Frauen wird das HUS besonders nach Schwangerschaften [11,21,22,50,52,53] und unter oralen Antikonzeptiva beobachtet [7,57]. Trotz vieler Hinweise auf ein vorausgehendes infekti6ses Geschehen [2,14] ist bislang kein einheitlich ausl6sender Faktor oder pathogenetischer Mechanismus erwiesen.…”