Nephrotic Syndrome and Focal Glomerulosclerosis in Adult Polycystic Kidney Disease

Montoyo, C.; Martı́nez, Miguel Ángel; Campo, Carlos; Mazuecos, Auxiliadora; Andrés, Amado; Praga, Manuel

doi:10.1159/000186845

Cited by 14 publications

(12 citation statements)

References 6 publications

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“…The main explanation of this anemia that majority of patients in our cohort diagnosed with advanced renal insufficiency. Massive proteinuria is a rare finding [14], and none of our patients had proteinuria in the nephrotic range. The reason of proteinuria in ADPKD is still unclear; however possible explanation would be damage to capillary endothelium and glomerulosclerosis due to hypertension [15].…”

Section: Discussionmentioning

confidence: 55%

Clinical Presentation and Outcomes of Autosomal Dominant Polycystic Kidney Disease in the Elderly

Helal¹,

Lassoued²,

Maı̈z³

et al. 2013

AJMSM

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The patient characteristics and outcomes associated with autosomal dominant polycystic kidney disease (ADPKD) have not been characterized in elderly population. The purpose of theis study was to delineate clinical presentation and outcome of ADPKD in elderly patients. We performed a retrospective study. Thirty four elderly patients were diagnosed with ADPKD between 1975 and 2005. The diagnosis of ADPKD was made using family history and ultrasound. There were 21 (61.7%) males and 13 (38.3%) females. The mean age at the time of diagnosis of ADPKD was 69.74 ± 3.36 years (range, 65-79 years). The earliest clinical features were renal failure in 67.6%, back pain in 38.2%, and hypertension in 17.6%. Most common form of presentation was hypertension in 70.6%. Kidneys were palpable in 26.5%, and liver was palpable in 32.4%. Left ventricular hypertrophy confirmed by transthoracic echocardiography was found in 5(1.5%) patients. Three (0.8%) patients had colonic diverticula and two (0.6%) had neurological manifestation. Twenty six 26 patients (76.5%) patients had end stage renal disease and 30 patients (88.23 %) patients had anemia. Median follow-up period for all patients was 17.9 months (range, 1-120 months). Two (0.6%) patients developed renal carcinoma while five patients (14.7%) died within six years following diagnosis Anemia was the strongest and an independent predictor of poor renal outcome. (p<0.03). The diagnosis of ADPKD in elderly patients was made late in most cases, with patients already at end stage renal disease. Anemia is risk factor of poor renal prognosis. Eearly diagnosis and efforts at prevention of the disease progression and complications are most essential.

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Section: Discussionmentioning

confidence: 55%

Clinical Presentation and Outcomes of Autosomal Dominant Polycystic Kidney Disease in the Elderly

Helal¹,

Lassoued²,

Maı̈z³

et al. 2013

AJMSM

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“…These include focal segmental glomerular sclerosis, membranoproliferative type-1 glomerulonephritis, mesangio-proliferative glomerulonephritis, amyloidosis, and IgA nephropathy [5][6][7][8].…”

Section: Discussionmentioning

confidence: 99%

Idiopathic membranous nephropathy associated with polycystic kidney disease

et al. 2009

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Membranous nephropathy (MN) and polycystic kidney disease are both relatively rare diseases in children. On rare exceptions, these two conditions have been associated in adults. We report here the first case of a pediatric patient with this association. This 6-year-old child presented with gross hematuria, nephrotic syndrome, and mild renal failure. A renal ultrasound subsequently revealed that the patient also had polycystic kidney disease.

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“…Only in 3 patients was pro teinuria exceeding 5 g/l found. In a recent review by Montoyo et al [7], only I out of 65 APKD had NS. Case reports of MGN as a complication of APKD do exist in the lit erature, but, to our knowledge, only 2 cases of MGN have been described in APKD to date.…”

Section: Membranous Glomerulonephritis Associated With Autosomal Domimentioning

confidence: 94%

Membranous Glomerulonephritis Associated with Autosomal Dominant Polycystic Kidney Disease

Saxena¹,

Hotchandani²,

Bhuyan

et al. 1993

Nephron

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Nephrotic Syndrome and Focal Glomerulosclerosis in Adult Polycystic Kidney Disease

Cited by 14 publications

References 6 publications

Clinical Presentation and Outcomes of Autosomal Dominant Polycystic Kidney Disease in the Elderly

Clinical Presentation and Outcomes of Autosomal Dominant Polycystic Kidney Disease in the Elderly

Idiopathic membranous nephropathy associated with polycystic kidney disease

Membranous Glomerulonephritis Associated with Autosomal Dominant Polycystic Kidney Disease

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