Nephrotic syndrome complicating adenocarcinoma of the lung with resolution after resection

Coltharp, William H.; Lee, Stanley M.; Miller, Robert F.; Averbuch, M

doi:10.1016/0003-4975(91)90810-d

Cited by 22 publications

(13 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There are conflicting data on which treatment modality is more appropriate. In a previous study, it was reported that complete surgical resection of small lesion lung cancers prevents the progression of nephrotic syndromes and decreases the excretion of urinary protein (14). In the present case, chemotherapy was administered following surgical intervention and nephropathy resolved during this process.…”

Section: Discussionmentioning

confidence: 60%

A case of membranous glomerulopathy associated with lung cancer and review of the literature

et al. 2017

View full text Add to dashboard Cite

Abstract. Membraneous nephropathy (MN) is the most commonly occurring nephrotic syndrome in adults as well as the most common paraneoplastic nephropathy associated with solid tumors, and it is mostly associated with gastrointestinal system and lung carcinomas. Accurate diagnosis is important as the treatment of paraneoplastic glomerulonephritis is very varied from that of idiopathic ones. In the current report, a case of a patient that was referred with proteinuria and edema and was diagnosed with lung cancer, and responded markedly to treatment of malignancy, with improvement of MN, is presented. Active cancer is present in all patients with paraneoplastic MN. In numerous patients, the paraneoplastic MN and cancer diagnoses are made within one year of each other. The treatment of paraneoplastic syndromes is usually associated with the treatment of primary malignancy. There are conflicting data on which treatment modality is more suitable. In conclusion, further studies are required in order to determine the actual incidence of cancer in patients with nephropathy, explain the physiopathological association between cancer and nephropathy and to determine the most suitable treatment approaches. IntroductionNephrotic syndrome is one of the most easily diagnosed kidney diseases due to its established criteria. It is a clinical entity characterized by proteinuria >3.5 g/1.73 m 2 for 24 h along with hypoalbuminemia, edema and hyperlipidemia. In glomerular diseases presenting with nephrotic syndrome, there is a defect in glomerular filtration barrier (1). Membranous nephropathy (MN), is a pathological entity characterized by diffuse thickening in the glomerular basement membrane, as viewed under light microscopy. Although 75% of MN cases are idiopathic, the remaining are associated with infections, malignancies, autoimmune diseases and drug toxicity (2).The diagnosis of paraneoplastic nephropathy is made according to certain criteria: Clinical and histological remission with complete removal of the tumor or complete remission with chemotherapy, nephrological relapse concurrent with the recurrence of malignancy and physiological connection between two diseases including tumor antigens and antitumor antibodies along with immune deposits (3). MN is the nephrotic syndrome occurring most frequently in adults and the paraneoplastic nephropathy detected most commonly in association with solid tumors (4), and it is most commonly associated with the gastrointestinal system and lung adenocarcinomas (1). Accurate diagnosis is important as the treatment of paraneoplastic glomerulonephritis is different from that of idiopathic nephropathies. The aim of the present report was to present the case of a patient who was referred with proteinuria and edema, was diagnosed with MN and subsequently lung cancer and responded markedly to treatment of malignancy with improvement of MN. Case reportA 62 year old male patient with a history of coronary artery disease and a history of smoking (36 pack-years) underwent kidney biopsy in July 2012 du...

show abstract

Section: Discussionmentioning

confidence: 60%

A case of membranous glomerulopathy associated with lung cancer and review of the literature

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Treatment for paraneoplastic nephrotic syndrome is complicated. Some studies have indicated the effectiveness of surgical treatment in curing paraneoplastic nephrotic syndrome [16,17]. However, there is no standard treatment for paraneoplastic nephrotic syndrome in nonsurgically malignant cases.…”

Section: Chemotherapy Treatments Was Begun Withmentioning

confidence: 99%

Nephrotic syndrome associated with carcinoma of unknown primary ‎treated with chemotherapy: A rare case report

Mohtashami

Bakhtiari

Hadian

et al. 2020

Eurasian Chem. Commun.

View full text Add to dashboard Cite

Different glomerular diseases are associated with various neoplasms. It seems obvious that Carcinoma of Unknown Primary (CUP) induced nephrotic syndrome is rare. In this regard, the present article introduces a patient suffering from nephrotic syndrome associated with CUP. Patient is a 65-year-old non-smoker male who referred to the clinic for one-month generalized edema. The patient was also complaining from coughing and bulky yellowish sputum with no signs of blood. Patient's chest radiography revealed pulmonary pleural effusion of the left lung, but no other pathological findings were revealed. Patient's cytology report of pleural fluid indicated metastatic carcinoma, and therefore, the patient needed additional examinations so that the origin of metastases (lung, gastrointestinal tract, pancreas, etc.) could be detected. Finally, chemotherapy treatments began when the patient was diagnosed with Carcinoma of Unknown Primary (CUP). With the continuation of chemotherapy treatment and follow-up after more than a year of treatment, the patient is now generally well-off; his nephrotic syndrome has also been in remission parallel to chemotherapy. Significant point in the treatment of this patient is proteinuria, hypercholesterolemia and hyponatremia remission in two stages of chemotherapy. These findings suggest probable para-neoplastic nephrotic syndrome. The treatment of paraneoplastic is the treatment of underlying cause.

show abstract

“…Although surgical therapy has been shown to be effective in paraneoplastic nephrotic syndrome [4], no standard therapy has been established, if the paraneoplastic nephrotic syndrome is associated with advanced cancer with an unresectable lesion. Although chemotherapy has been shown to cause the nephrotic syndrome to regress [9], it is not always applicable in patients with cancer presenting renal dysfunction [10].…”

Section: Discussionmentioning

confidence: 99%

“…It seems that the only effective treatment is complete resection of the neoplasm. For example, complete surgical resection of small lung cancers has been shown to suppress the progression of nephrotic syndrome, as evidenced by the reduction of urinary protein excretion [4]. On the other hand, treatment is difficult if the primary tumor is not resectable.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of Radiation Therapy in Nephrotic Syndrome Associated with Advanced Lung Cancer

Shikata

Hayashi

Yamazaki

et al. 1999

Nephron

View full text Add to dashboard Cite

Paraneoplastic nephrotic syndrome is rare, bur occurs mostly in lung cancer. The glomerular lesion usually exhibits membranous nephropathy. Although surgical therapy has been shown to be effective, the treatment of a paraneoplastic nephrotic syndrome has always been a challenge. Currently no standard therapy has been established, if the paraneoplastic nephrotic syndrome is associated with advanced cancer with unresectable lesions. We present 2 cases having paraneoplastic nephrotic syndrome associated with advanced squamous cell carcinoma of the lung. Radiation therapy of the primary tumor effectively caused regression of the paraneoplastic nephrotic syndrome without affecting the renal function. Our results suggest that irradiation can be the first choice in the treatment of nephrotic syndrome, if the primary tumor is unresectable.

show abstract

Nephrotic syndrome complicating adenocarcinoma of the lung with resolution after resection

Cited by 22 publications

References 8 publications

A case of membranous glomerulopathy associated with lung cancer and review of the literature

A case of membranous glomerulopathy associated with lung cancer and review of the literature

Nephrotic syndrome associated with carcinoma of unknown primary ‎treated with chemotherapy: A rare case report

Effectiveness of Radiation Therapy in Nephrotic Syndrome Associated with Advanced Lung Cancer

Contact Info

Product

Resources

About