Nephrotic Syndrome in Chronic Lymphocytic Leukaemia

Farrant, J. Mark; Taylor, C. G.; Beer, Stephen

doi:10.1111/j.1365-2141.1988.tb02383.x

Cited by 2 publications

(3 citation statements)

References 3 publications

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“…Up to now, only 9 cases of MCGN in CLL have been reported [3,4,[7][8][9][10][11]. Contrary to previously reported cases of MCGN associated with CLL, monoclonal IgM kappa-type gammopathy and cryoglobulinemia were observed in our patient as well, features that are much more typical for other types of glomerulopathy [5,16,17].…”

Section: Discussioncontrasting

confidence: 52%

“…With an incidence of 45%, the most frequent glomerulopathy in CLL is membranoproliferative glomerulonephritis (MPGN) [2,4,6] followed by membranous glomerulonephritis (MGN) [6]. So far, only 9 cases of CLL associated with minimal change glomerulonephritis (MCGN) have been described in the literature [3,4,[7][8][9][10][11] (table 1). In this paper, we present a further such case.…”

Section: Minimal Change Glomerulonephritis In Chronic Lymphocytic Leumentioning

confidence: 99%

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Minimal Change Glomerulonephritis in Chronic Lymphocytic Leukemia: Pathophysiological and Therapeutic Aspects

Alzamora

Schmidli²,

Hess

et al. 2006

Oncol Res Treat

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Background: So far, only 9 cases of minimal change glomerulonephritis (MCGN) related to chronic lymphocytic leukemia (CLL) have been described. Case Report: Our patient presented with severe nephrotic syndrome. Diagnostic biopsies confirmed MCGN and early-stage BCLL (Binet A). In contrast to previously described cases, kappa monoclonal IgM and cryoglobulins were also detected. The patient was treated with chlorambucil and prednisone. 3 weeks later, renal function and white blood cell (WBC) count were completely normal. Discussion: Although, in most cases, renal disease and CLL present separately, there is evidence for a causal relationship between the two disorders. Although it is widely approved that early-stage CLL should not be treated by medication, the severe nephrotic syndrome in our patient required immediate intervention. So far, there is no standard therapy for MCGN associated with CLL. Our combination therapy resulted in normalization of the nephrotic syndrome and the WBC count. Hence, we emphasize the importance of early recognition of renal symptoms in CLL and propose a successful therapy for nephrotic syndrome in MCGN associated with early-stage B-CLL. Additionally, the pathophysiological and therapeutic aspects of MCGN associated with CLL are retrospectively discussed.

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Section: Discussioncontrasting

confidence: 52%

Section: Minimal Change Glomerulonephritis In Chronic Lymphocytic Leumentioning

confidence: 99%

Minimal Change Glomerulonephritis in Chronic Lymphocytic Leukemia: Pathophysiological and Therapeutic Aspects

Alzamora

Schmidli²,

Hess

et al. 2006

Oncol Res Treat

View full text Add to dashboard Cite

show abstract

“…Seven cases of CLL and minimal-change nephrotic syndrome have been reported in the literature [3][4][5][6][7]. Details of management are available for 4 of these patients.…”

mentioning

confidence: 99%