Nephrotoxic Effect of Gentamicin and Amikacin in Neonates with Infection

Abstract

Background: Infection and its treatment as a common problem in children may induce different complications. Ampicillin and aminoglycosides, as choice drugs for this condition, may have many important side effects, such as nephrotoxic side effects. Therefore, the aim of this study was to evaluate the nephrotoxic effect of gentamicin and amikacin in neonates with infection. Methods: This clinical trial and double blind study was conducted on 80 children with aminoglycosides addministration. Initially, during hospital admission, serum and urine samples were collected for diagnosis of infection. Children based on their treatment were divided to 2 groups, 40 children were treated by ampicillin and amikacin and 40 children were treated by ampicillin and gentamicin, during a 7-day period. At the end of the treatment period, serum and urine samples were taken for measurment of laboratory variables, and GFR, for evaluation of kidney function. Results: Blood Urea Nitrogen (BUN), creatinine and GFR before and after treatment in the two groups did not have statistically significant differences (P > 0.05). In addition age, gender, birth age, infection type, occupation, and education of parents and milk type were equal in the 2 groups. Conclusions: Based on the present study, there were no significant differences between nephrotoxic effect of gentamicin and amikacin in the two groups.

Recomendaciones para diagnóstico y tratamiento de la infección del tracto urinario en pediatría. Parte 2: Grupo de trabajo asociado al Comité de Antimicrobianos, Sociedad Chilena de Infectología (SOCHINF)

“…Nefrotoxicidad: Es un efecto bien conocido de este grupo que podría presentarse en 20 a 33% de los pacientes pediátricos 39 , principalmente en los tratamientos prolongados y a menores edades 40 . Algunos estudios observacionales han respaldado una mayor toxicidad renal de gentamicina frente a amikacina en ciertos grupos de pacientes 41 mientras que otros estudios no encuentran diferencias 42 .…”

Antibiotic regimens for late-onset neonatal sepsis

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Dopamine and Drip Lasix in Pediatrics with Oliguria: A Clinical Trial Study

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