Nephrotoxic effects of lead nitrate exposure in diabetic and nondiabetic rats: Involvement of oxidative stress and the protective role of sodium selenite

Baş, Hatice; Kalender, Yusuf

doi:10.1002/tox.22130

Cited by 29 publications

(34 citation statements)

References 37 publications

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“…Recently, it has been shown that AgNP induces mitochondrial stress and treatment with selenite is capable of preventing the adverse effects of AgNP on the mitochondria [46]. Also possible application of Se on oxidative processes is known [47,48].…”

Section: Discussionmentioning

confidence: 98%

Sodium Selenite Protects Against Silver Nanoparticle-Induced Testicular Toxicity and Inflammation

Ansar

Abudawood

Hamed

et al. 2016

Biol Trace Elem Res

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Metal nanomaterials hold great potential and play an important role in consumer products. However, the increasing use of nanomaterials has raised concern over inadvertent exposure and potential risks for human health and the environment. Henceforth, in vivo testing of nanoparticles and protection against its toxicity is required. Using rat as an animal model, effect of sodium selenite (Se), an essential trace element, on rat testes exposed to silver nanoparticles (AgNPs) was evaluated. Male rats were treated with AgNPs (5 mg/kg/b.w) i/p or Se (0.2 mg/kg/b.w) by gavage. AgNP administration decreased Glutathione (GSH) levels and activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) and increased levels of malondialdehyde (MDA) and expression of interleukin-1 beta (IL-1β), IL-6, and tumor necrosis factor alpha (TNF-α). However, treatment with Se increased GSH levels and activities of SOD, CAT, and GPx compared with AgNP-treated group and decreased the level of MDA and inflammatory biomarkers significantly (p < 0.05) as compared with AgNP-treated group. Light microscopic analyses also revealed that AgNP induced histopathological changes in testes tissue. Further, protection by Se on biochemical results was confirmed by alleviation of the histopathological changes in the tissue. Results show the adverse effects of AgNPs on the male reproductive tract, particularly spermatogenesis, and suggest that Se possesses significant potential in reducing AgNP-induced testicular toxicity.

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Section: Discussionmentioning

confidence: 98%

Sodium Selenite Protects Against Silver Nanoparticle-Induced Testicular Toxicity and Inflammation

Ansar

Abudawood

Hamed

et al. 2016

Biol Trace Elem Res

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“…There are many studies which have indicated that lead and mercury exposure could cause biochemical and physiological dysfunctions in experimental animals and humans [ 23,24 ]. Recently, oxidative stress has become the focus of interest as a potential cause of male infertility [ 8 ].Reactive oxygen species (ROS) are the subject of intense research because of their effects on cellular pathogenesis [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Status, Lipid Peroxidation and Testis-histoarchitecture Induced by Lead Nitrate and Mercury Chloride in Male Rats

Baş

Kalender

2016

Braz. arch. biol. technol.

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“…Selmanoğlu et al (34) reported that treatment of rats with furan showed changes in antioxidant enzyme activities. Connections between chemical treatment and alterations in antioxidant enzyme activities have been proven (36).…”

Section: Figure 6 (A) Liver Section Of Control Rats Cv: Central Veinmentioning

confidence: 99%

Furan-induced hepatotoxic and hematologic changes in diabetic rats: the protective role of lycopene

Baş

Pandır

Kalender

2016

Archives of Industrial Hygiene and Toxicology

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Furan forms as a result of thermal treatment of food and induces harmful effects on organisms. In our work, lycopene, furan, and a combination of the two were given to diabetic male rats for 28 days. Hematological changes, total protein and cholesterol, triglyceride, and albumin levels, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and alkaline phosphatase activities of the serum, malondialdehyde levels, glutathione peroxidase, catalase, glutathione-S-transferase, superoxide dismutase activities, DNA damage in liver tissues and hepatic histopathological alterations were compared to a control group. There were significant changes in the liver function tests, DNA damage, activities of antioxidant enzymes, and malondialdehyde levels between diabetic control and non-diabetic control groups, between diabetic control and diabetic lycopene groups, and also between diabetic furan and diabetic control groups. In diabetic lycopene and diabetic furan + lycopene treated groups we designated the preventive effects of lycopene against diabetes and furan, however, on the analysed parameters only. In spite of some pathological alterations designated in diabetic furan treated group's liver, fewer pathological alterations were observed in furan+lycopene treated groups at the end of week 4. Consequently, lycopene significantly reduced furan-and diabetes-induced toxicity in rat liver.

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Nephrotoxic effects of lead nitrate exposure in diabetic and nondiabetic rats: Involvement of oxidative stress and the protective role of sodium selenite

Cited by 29 publications

References 37 publications

Sodium Selenite Protects Against Silver Nanoparticle-Induced Testicular Toxicity and Inflammation

Sodium Selenite Protects Against Silver Nanoparticle-Induced Testicular Toxicity and Inflammation

Antioxidant Status, Lipid Peroxidation and Testis-histoarchitecture Induced by Lead Nitrate and Mercury Chloride in Male Rats

Furan-induced hepatotoxic and hematologic changes in diabetic rats: the protective role of lycopene

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