Nephrotoxicity evaluation of 3-monochloropropane-1,2-diol exposure in Sprague-Dawley rats using data-independent acquisition-based quantitative proteomics analysis

Bibliometric Analysis of Research Trends on 3-Monochloropropane-1,2-Diol Esters in Foods

“…66 The results of renal proteomics also suggested that proteins associated with oxidative stress such as Gstp1, Hmox1, and MFN2 were altered after 3-MCPDE treatment. 67 These results demonstrate that the toxic effects induced by 3-MCPDE are related to oxidative stress. However, further investigations are needed to understand how 3-MCPDE induces oxidative stress-related protein alterations and whether oxidative stress occurring in different organs share the same mechanism.…”

“…While exploring 3-MCPDE-induced renal injury, the researchers noted that 3-MCPD intake induces the synergistic nephrotoxicity and the systemic toxicity via NLRP3, and induces the inflammasome activation . The results of renal proteomics also suggested that proteins associated with oxidative stress such as Gstp1, Hmox1, and MFN2 were altered after 3-MCPDE treatment . These results demonstrate that the toxic effects induced by 3-MCPDE are related to oxidative stress.…”

“…In addition, the intake of 3-MCPDE also causes metabolic disturbances in the body. Proteomics analysis has shown that 3-MCPD affects enzymes involved in the endogenous metabolism of carbohydrates, amino acids, nitrogen, fatty acids, lipids, and tricarboxylic acid (TCA) cycle, providing a partial explanation for the nephrotoxicity of 3-MCPDE. ,, …”

“…Proteomics analysis has shown that 3-MCPD affects enzymes involved in the endogenous metabolism of carbohydrates, amino acids, nitrogen, fatty acids, lipids, and tricarboxylic acid (TCA) cycle, providing a partial explanation for the nephrotoxicity of 3-MCPDE. 2,67,68 In summary, the kidney is the main target organ for the toxicity of 3-MCPDE. Other toxicity of 3-MCPDE, such as testicular toxicity, hepatotoxicity, neurotoxicity, and genotoxicity, have been reported in several studies.…”

“…These two pathways are involved in apoptosis and necrosis. Meanwhile, renal protein analysis revealed that 3-MCPDE induced changes in proteins associated with apoptosis and necrosis, which in turn activated related pathways and ultimately led to kidney injury. , Similarly, Liu et al suggested that 3-MCPDE could induce cell necrosis via NLRP3 and thus caused nephrotoxicity. In addition, 3-MCPD 1-palmitate could alter the mRNA expression of genes related to MAPK, p53, and cell apoptotic signaling pathways in SD rats .…”